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المؤلفون: Rita Mendes, Catarina Brito, Megan C. Cox, Inês A. Isidro, Kathleen Halwachs, Fernanda Silva, Julie J Purkal, Adelyn L Zelaya-Lazo, Ana Félix, Erwin R. Boghaert, Teresa F. Mendes
المساهمون: Instituto de Tecnologia Química e Biológica António Xavier (ITQB), Centro de Estudos de Doenças Crónicas (CEDOC), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAPمصطلحات موضوعية: Cancer microenvironment, Science, Drug development, Antineoplastic Agents, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Lactate dehydrogenase, Cell Line, Tumor, Neoplasms, Spheroids, Cellular, Drug Discovery, Tumor Cells, Cultured, Medicine, Animals, Humans, General, Cancer models, 030304 developmental biology, 0303 health sciences, Multidisciplinary, L-Lactate Dehydrogenase, business.industry, Culture growth, 3. Good health, Clinical trial, chemistry, 030220 oncology & carcinogenesis, Cancer research, Drug Screening Assays, Antitumor, business, Ex vivo
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8ac81b3c771941eb41563f083c9b56Test
https://doaj.org/article/6ba6021cf4734f4ebc89722a5ae55c02Test -
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المؤلفون: Mohamed K. Abdel-Rafei, Noura M Thabet, Nermeen M El Bakary, Ghada El Tawill, Khaled Shaaban Azab, Neama M El Fatih
المصدر: Journal of Radiation Research
مصطلحات موضوعية: Necrosis, Antioxidant, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Fucoxanthin, Xanthophylls, Kidney, Antioxidants, chemistry.chemical_compound, Mice, 0302 clinical medicine, chemistry.chemical_classification, 0303 health sciences, Apelin Receptors, Radiation, Glutathione peroxidase, NF-kappa B, Apelin-13/APJ, Malondialdehyde, Oxidants, Apelin, medicine.anatomical_structure, Liver, Matrix Metalloproteinase 9, Organ Specificity, 030220 oncology & carcinogenesis, Intercellular Signaling Peptides and Proteins, Matrix Metalloproteinase 2, medicine.symptom, MMP-9, Whole-Body Irradiation, Signal Transduction, medicine.medical_specialty, α-7nAchR, 03 medical and health sciences, Lactate dehydrogenase, Internal medicine, medicine, Animals, Radiology, Nuclear Medicine and imaging, Fundamental Radiation Science, 030304 developmental biology, Inflammation, Tissue Inhibitor of Metalloproteinase-1, L-Lactate Dehydrogenase, Monocyte, Glutathione, γ-radiation, Endocrinology, chemistry, Gamma Rays, AcademicSubjects/SCI00960, AcademicSubjects/MED00870
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e30214c17e6d8f3108e2b41351abd16bTest
http://europepmc.org/articles/PMC8273792Test -
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المؤلفون: Philip L. Lorenzi, Wuhao Lu, Meng Cui, Xiangdong Le, Yunyun Chen, Anastasios Maniakas, Lin Tan, Vlad C. Sandulache, Keith A. Michel, Stephen Y. Lai, Nagireddy Putluri, Abdallah S.R. Mohamed, Joshua S. Niedzielski, James A. Bankson, Collin J. Harlan, Ying C. Henderson
المصدر: Br J Cancer
مصطلحات موضوعية: Cancer Research, Lactate dehydrogenase A, Down-Regulation, Mice, Nude, Context (language use), Gene Expression Regulation, Enzymologic, Article, Small hairpin RNA, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Lactate dehydrogenase, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Humans, Metabolomics, Glycolysis, Molecular Targeted Therapy, Enzyme Inhibitors, RNA, Small Interfering, education, education.field_of_study, L-Lactate Dehydrogenase, Squamous Cell Carcinoma of Head and Neck, Chemistry, medicine.disease, Xenograft Model Antitumor Assays, Head and neck squamous-cell carcinoma, Gene Expression Regulation, Neoplastic, Oncology, Head and Neck Neoplasms, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, Cancer research, Feasibility Studies, Female, Reprogramming, Algorithms, Intracellular
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb89361b349a5c507df84525a5db944Test
https://doi.org/10.1038/s41416-021-01297-xTest -
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المؤلفون: Lingmei Qian, Zijie Cheng, Bing Zhang, Li Zhang, Mengwen Feng, Xuejun Wang, Jingjing Ding, Hao Zhang
المصدر: Journal of Cellular and Molecular Medicine
مصطلحات موضوعية: 0301 basic medicine, Male, STAT3 Transcription Factor, Cell Survival, myocardial I/R, Apoptosis, Myocardial Reperfusion Injury, Pharmacology, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Fibrosis, Lactate dehydrogenase, Troponin I, medicine, Animals, Myocytes, Cardiac, Viability assay, EIP‐22, STAT3, Cells, Cultured, chemistry.chemical_classification, Membrane Potential, Mitochondrial, Reactive oxygen species, TUNEL assay, biology, L-Lactate Dehydrogenase, JAK2/STAT3, Cell Biology, Original Articles, Janus Kinase 2, Tyrphostins, medicine.disease, peptide, Rats, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Original Article, Peptides, Reactive Oxygen Species, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada0c392ff34497ba4ef0e8063bcc90fTest
http://europepmc.org/articles/PMC8034444Test -
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المؤلفون: Kaneez Fatima, Abha Meena, Suaib Luqman, Nusrat Masood, Zahoor Ahmad Wani
المصدر: Journal of Advanced Research
مصطلحات موضوعية: TRIG, Triglyceraldehyde, Skin Neoplasms, Cell, DOXO, Doxorubicin, Hyaluronidase, Pharmacology, NaOH, Sodium hydroxide, Polymerization, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, Mice, 0302 clinical medicine, BIL, Bilirubin total & direct, Neomenthol, PEP A, pepstatin A, Cancer biomarker, MEF, Mean erythrocyte fragility, HYAL, Hyaluronidase, PBS, Phosphate buffer saline, CM-H2DCFDA, Chloromethyl derivative of dichloro fluorescin diacetate, HA, Hyaluronic acid, Epidermoid carcinoma, Human epidermoid carcinoma, 030220 oncology & carcinogenesis, RBC, Red blood cell, DMEM, Dulbecco’s minimal essential media, SRB, Sulphorhodamine B, BUN, Blood urea nitrogen, FACS, Fluorescence-Activated Cell Sorting, AKLP, Alkaline phosphatase, Hyaluronoglucosaminidase, NADPH, Nicotinamide adenine dinucleotide phosphate hydrogen, TMPD, N,N,N′,N′-tetramethyl-p-phenylenediamine, Article, 03 medical and health sciences, In vivo, Ehrlich Ascites Carcinoma, BE, Binding energy, Humans, CATD, Cathepsin D, LDH, Lactate dehydrogenase, COX-2, Cyclooxygenase 2, FOX, Ferrous oxidation-xylenol orange, DMSO, Dimethyl sulfoxide, mTOR, Mammalian target of rapamycin, In vitro, Ab/Am, Antibiotic/antimycotic, NRU, Neutral red uptake, EC50, Half maximal effective concentration, 030104 developmental biology, IC50, Half maximal inhibitory concentration, EAC, Ehlrich Ascites Carcinoma, RPMI, Roswell park memorial institute, ROS, Reactive oxygen species, 0301 basic medicine, HDL, High density lipoprotein, TNBS, Trinitrobenzenesulphonic acid, PI3K, Phosphotidyl inositol-3 kinase, URIC, Uric acid, DNA, Deoxyribonucleic acid, GAPDH, Glyceraldehyde 3-phosphate dehydrogenase, HEPES, N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid, Tubulin, OECD, Organization for Economic Co-operation and Development, SGPT, Alanine aminotransferase, LOX-5, Lipoxygenase-5, DFMO, α-difluoro methyl ornithine, Multidisciplinary, WBC, White blood cell, Chemistry, ELISA, enzyme-linked immunosorbent assay, PKB/Akt, Protein kinase B, AA, Arachidonic acid, RNase A, Ribonuclease A, TPR, Total protein, Molecular Docking Simulation, medicine.anatomical_structure, TCA, Tricarboxylic acid, CHOL, Cholesterol, Ki, Inhibitory constant, medicine.drug, ODC, Ornithine decarboxylase, DHFR, Dihydrofolatereductase, BSA, Bovine serum albumin, PDB, Protein Data Bank, medicine, Animals, MMP, Mitochondrial membrane potential, DCFDA, 2′,7′ dichloro fluorescin diacetate, RNA, Ribonucleic acid, RIPA, Radio immune precipitation assay buffer, EDTA, Ethylene diamine tetra acetic acid, IC50, TPA, 12-O-Tetradecanoylphorbol-13-acetate, ComputingMethodologies_COMPUTERGRAPHICS, TRPM8, Transient receptor potential member 8, Cell Proliferation, HDAC, Histone deacetylase, MTX, Methotrexate, OF, Osmotic fragility, PI, Propidium iodide, FDA, Food and Drug Administration, HEK293 Cells, PDT, Podophyllotoxin, Cell culture, NAC, N-acetyl cysteine, SGOT, Aspartate aminotransferase, CRTN, Creatinine, FBS, Fetal bovine serum, PCR, Polymerase chain reaction, Rh123, Rhodamine 123, Ex vivo, IDT, Integrated DNA Technologies
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7618e7dc6e2d535e1930d5f8c2bf7d7eTest
https://doi.org/10.1016/j.jare.2021.06.003Test -
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المؤلفون: Bowen Gao, Weidong Zhang, Yanfeng Wu, Huiyong Shen, Yangbai Sun, Fengfeng Li, Mengjun Ma, Sanhong Liu, Yuhang Jiang, Meng Chen
المصدر: Theranostics
مصطلحات موضوعية: 0301 basic medicine, Jumonji Domain-Containing Histone Demethylases, Lung Neoplasms, Cell, Mice, Nude, Medicine (miscellaneous), Bone Neoplasms, LDHA, Biology, Metastasis, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Histone demethylation, Cell Movement, In vivo, Cell Line, Tumor, Lactate dehydrogenase, medicine, Animals, Humans, KDM6B, Molecular Targeted Therapy, Precision Medicine, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Osteosarcoma, L-Lactate Dehydrogenase, Cell migration, Benzazepines, Prognosis, medicine.disease, Xenograft Model Antitumor Assays, Up-Regulation, Histone Code, Pyrimidines, Lung metastasis, 030104 developmental biology, medicine.anatomical_structure, Real-time polymerase chain reaction, chemistry, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, Cancer research, H3K27me3 demethylation, Research Paper
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3e18f7ec254eb7663021f8f7473dfaTest
https://doi.org/10.7150/thno.53347Test -
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المؤلفون: Zhao Cheng, Zhihua Wang, Yi-Fang Yi, Wen-Yong Kuang, Lingli Yuan, Hongling Peng, Guangsen Zhang, Yafei Yin, Yajuan Cui, Fan-Jie Gong, Ruijuan Li, Heng Li, Haiying Zhong, Haizhi Yu
المصدر: Cancer Communications, Vol 40, Iss 10, Pp 501-517 (2020)
Cancer Communicationsمصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cancer Research, CRISPR/Cas9 gene‐editing, oxamate, T-Lymphocytes, Lactate dehydrogenase A, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Jurkat cells, lcsh:RC254-282, LDHA, Animals, Genetically Modified, Proto-Oncogene Proteins c-myc, Jurkat Cells, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, 0302 clinical medicine, Animals, Humans, education, Protein kinase B, GSK3B, Zebrafish, PI3K/AKT/mTOR pathway, Oxamic Acid, education.field_of_study, Gene knockdown, Glycogen Synthase Kinase 3 beta, Kinase, Chemistry, Original Articles, Cell cycle, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, T‐cell lymphoblastic leukemia, 030104 developmental biology, Oncology, Gene Knockdown Techniques, 030220 oncology & carcinogenesis, Cancer research, transgenic zebrafish model, Original Article, Female, Lactate Dehydrogenase 5, Proto-Oncogene Proteins c-akt, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a7a0d309db1a672a3721ab79b90911Test
https://doaj.org/article/05c2fa1e4b2c4d5f9ac1b8904efb8186Test -
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المؤلفون: Da-Won Hong, Sung Hee Hong, Tae Woo Kim, Joung Whan Park
المصدر: British Journal of Cancer
مصطلحات موضوعية: Cancer Research, Cell cycle checkpoint, Lung Neoplasms, Cancer therapy, Apoptosis, Cell Cycle Proteins, Ataxia Telangiectasia Mutated Proteins, Ligands, Radiation Tolerance, chemistry.chemical_compound, Mice, 0302 clinical medicine, Onium Compounds, Carcinoma, Non-Small-Cell Lung, Adipocytes, Anilides, RNA, Small Interfering, Receptor, Cytotoxicity, Luciferases, Membrane Potential, Mitochondrial, Mice, Inbred BALB C, NADPH oxidase, biology, Cell Death, Chemistry, Caspase 3, Imidazoles, Cell Differentiation, 3T3 Cells, Caspase 9, Tumor Burden, Oncology, 030220 oncology & carcinogenesis, Female, Lung cancer, Signal Transduction, Programmed cell death, Epithelial-Mesenchymal Transition, Mice, Nude, Article, 03 medical and health sciences, Lactate dehydrogenase, Cell Line, Tumor, medicine, Animals, Humans, L-Lactate Dehydrogenase, Cell Cycle Checkpoints, medicine.disease, PPAR gamma, Purines, biology.protein, Cancer research, Thiazolidinediones, Tumor Suppressor Protein p53, Reactive Oxygen Species, Azo Compounds, DNA Damage
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3d84cfb28effda0709cc85c379ee0aTest
http://europepmc.org/articles/PMC7723055Test -
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المؤلفون: Emad S. Alnemri, Teresa Fernandes-Alnemri, Jian Xie, Victor L. J. Tybulewicz, Aura Enache, Robert Köchl, Lindsey Mayes-Hopfinger, Chou Long Huang
المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communicationsمصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Male, Pyrrolidines, Inflammasomes, Neutrophils, Interleukin-1beta, General Physics and Astronomy, Inflammasome, 0302 clinical medicine, WNK Lysine-Deficient Protein Kinase 1, Conditional gene knockout, Multidisciplinary, integumentary system, Chemistry, Caspase 1, Pyroptosis, Imidazoles, Cell biology, 030220 oncology & carcinogenesis, Female, Intracellular, medicine.drug, Cell death, Science, Protein Serine-Threonine Kinases, Models, Biological, General Biochemistry, Genetics and Molecular Biology, Article, Proinflammatory cytokine, 03 medical and health sciences, Chlorides, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Kinase activity, Monocytes and macrophages, Innate immune system, L-Lactate Dehydrogenase, Macrophages, General Chemistry, Immunity, Innate, Mice, Inbred C57BL, Tamoxifen, 030104 developmental biology, Potassium
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f780841c38901b3d5be2b16ce4f2bdTest
https://doaj.org/article/e7b7e958ca504bdc89a48c00f18c7b6cTest -
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المصدر: BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-11 (2021)
BMC Pharmacology & Toxicologyمصطلحات موضوعية: 0301 basic medicine, Male, Bilirubin, medicine.medical_treatment, RM1-950, Pharmacology, Protective Agents, Melittin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Lactate dehydrogenase, Malondialdehyde, RA1190-1270, medicine, Isoniazid, Animals, Tuberculosis, Pharmacology (medical), Aspartate Aminotransferases, Bee venom, Saline, Rifampicin, business.industry, Hepatotoxicity, Alanine Transaminase, Glutathione, Blood Proteins, Alkaline Phosphatase, Melitten, Rats, 030104 developmental biology, chemistry, Liver, 030220 oncology & carcinogenesis, Toxicology. Poisons, Alkaline phosphatase, Therapeutics. Pharmacology, Chemical and Drug Induced Liver Injury, Rifampin, business, medicine.drug, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0dc8db1532b81b74f63f446338ebd8Test
https://doaj.org/article/bf86734e1c1e4ae18f70398a1043577fTest