نتائج البحث

1

SARS–CoV-2–specific T cell responses and correlations with COVID-19 patient predisposition

المؤلفون: Katrin Moira Heim, Martin E. Kreis, Stefan Angermair, Fabian Halleck, Arne Sattler, Katja Kotsch, Helena Stockmann, Dmytro Khadzhynov, Sascha Treskatsch

المصدر: J Clin Invest

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e03688bab38d81eca8efbaf0e659dfaTest
https://doi.org/10.1172/jci140965Test

2

PD-1 blockade improves Kupffer cell bacterial clearance in acute liver injury

المؤلفون: Matthew K. Siggins, Wafa Khamri, Thomas O’Connor, Evangelos Triantafyllou, Mark Thursz, Marie-Anne Mawhin, Mark J. W. McPhail, Hannah C. Husbyn, Kevin J. Woollard, Sujit Mukherjee, Marina Botto, Cathrin Gudd, Robert D. Goldin, Christine Bernsmeier, Charalambos G. Antoniades, Lucia A. Possamai, Francesca M. Trovato, Julia Wendon, Hiromi Kudo

المساهمون: Medical Research Council (MRC)

المصدر: The Journal of Clinical Investigation

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Kupffer Cells, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Immunology, Flow cytometry, Sepsis, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Animals, Humans, Immune Checkpoint Inhibitors, 11 Medical and Health Sciences, Acetaminophen, Mice, Knockout, Innate immunity, Liver injury, Innate immune system, Bacteria, Hepatology, medicine.diagnostic_test, business.industry, Macrophages, Monocyte, Kupffer cell, Bacterial Infections, General Medicine, Immunotherapy, Middle Aged, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, Chemical and Drug Induced Liver Injury, business, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57ff30014337155b03c74b6c2ac765aTest
https://doi.org/10.1172/jci140196Test

3

CD19 CAR T cell product and disease attributes predict leukemia remission durability

المؤلفون: Hannah Brakke, Olivia Finney, Roxana Hicks, Daniel Li, Stephanie Rawlings-Rhea, Rebecca Gardner, Ben Futrell, Marisa Lopez, Michael C. Jensen, Rimas J. Orentas, Danielle Doolittle

المصدر: J Clin Invest

مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Adoptive cell transfer, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Kaplan-Meier Estimate, Hematopoietic stem cell transplantation, CD8-Positive T-Lymphocytes, Lymphocyte Activation, Immunotherapy, Adoptive, 0302 clinical medicine, Recurrence, Cytotoxic T cell, Child, Hepatitis A Virus Cellular Receptor 2, Leukemia, Receptors, Chimeric Antigen, Gene Expression Regulation, Leukemic, Remission Induction, Hematopoietic Stem Cell Transplantation, General Medicine, Aplasia, Lymphocyte Activation Gene 3 Protein, Phenotype, medicine.anatomical_structure, Child, Preschool, 030220 oncology & carcinogenesis, Female, Adult, medicine.medical_specialty, Adolescent, Antigens, CD19, Disease-Free Survival, Immunophenotyping, Young Adult, 03 medical and health sciences, Antigen, Antigens, CD, Internal medicine, medicine, Humans, B cell, Cell Proliferation, Tumor Necrosis Factor-alpha, business.industry, Infant, medicine.disease, Chimeric antigen receptor, 030104 developmental biology, Commentary, K562 Cells, business, CD8

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a113c5e07f7fbde58d76de414a97babfTest
https://doi.org/10.1172/jci125423Test

4

PD-1 blockade partially recovers dysfunctional virus–specific B cells in chronic hepatitis B infection

المؤلفون: Simon P. Fletcher, Christian R. Frey, Magdeleine Hung, Nina Le Bert, Patrick T F Kennedy, Loghman Salimzadeh, Antonio Bertoletti, Nikolai Novikov, Evan W. Newell, Charles-A. Dutertre, Upkar S. Gill

المصدر: Journal of Clinical Investigation. 128:4573-4587

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45762c58d7ea2f01d7c08e142fe9c31eTest
https://doi.org/10.1172/jci121957Test

5

Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration

المصدر: JCI Insight
JCI Insight, Vol 5, Iss 17 (2020)

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Cancer immunotherapy, Brain cancer, Mice, 0302 clinical medicine, 5'-Nucleotidase, Immune Checkpoint Inhibitors, Cells, Cultured, Brain Neoplasms, Apyrase, Glioma, General Medicine, Middle Aged, Isocitrate Dehydrogenase, Oncology, 030220 oncology & carcinogenesis, Medicine, Female, Immunosuppressive Agents, Research Article, medicine.drug, Adult, IDH1, Receptor, Adenosine A2A, Immunology, 03 medical and health sciences, Immune system, Downregulation and upregulation, Antigens, CD, Cell Line, Tumor, medicine, Animals, Humans, Aged, business.industry, Therapeutic effect, medicine.disease, Adenosine, Adenosine receptor, Mice, Inbred C57BL, 030104 developmental biology, Cancer research, Neoplasm Grading, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b7362d1d0c19278cd2192b48b6dbf5Test
https://doi.org/10.1172/jci.insight.134386Test

6

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target

المؤلفون: Mark A. Morgan, Robert A. Burger, Mireia Uribe-Herranz, Stefano Pierini, Erin George, Fiona Simpkins, Janos L. Tanyi, Andrea Facciabene, Ronny Drapkin

المصدر: JCI Insight, Vol 5, Iss 16 (2020)
JCI Insight

مصطلحات موضوعية: 0301 basic medicine, Adult, Forkhead Box Protein L2, medicine.medical_treatment, Population, Programmed Cell Death 1 Receptor, Immunology, Immune Targeting, Cancer immunotherapy, Mice, Inbred Strains, Cancer Vaccines, 03 medical and health sciences, Epitopes, 0302 clinical medicine, Immune system, Lymphocytes, Tumor-Infiltrating, Pregnancy, Cell Line, Tumor, Immune Tolerance, Tumor Microenvironment, Vaccines, DNA, Medicine, Animals, Humans, education, Immune Checkpoint Inhibitors, Granulosa Cell Tumor, education.field_of_study, business.industry, Tumor-infiltrating lymphocytes, General Medicine, Middle Aged, Xenograft Model Antitumor Assays, 030104 developmental biology, Forkhead box L2, Immunization, Oncology, Tumor progression, 030220 oncology & carcinogenesis, Cancer research, Female, business, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255c99bb3ed436759c3786738dc4cef4Test
https://doaj.org/article/3ee8feab99b74b3781439e0dd4109565Test

7

Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy

المؤلفون: Tasuku Honjo, Toyohiro Hirai, Yuichi Sakamori, Yasushi Okuno, Maryam Akrami, Fumihiko Matsuda, Ryusuke Hatae, Hiroaki Ozasa, Hironori Yoshida, Kazuhiro Sonomura, Kenji Chamoto, Kei Taneishi, Shuji Kawaguchi, Sidonia Fagarasan, Izuru Masuda, Young Hak Kim

المصدر: JCI Insight. 5

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Lung Neoplasms, Metabolite, medicine.medical_treatment, T cell, Programmed Cell Death 1 Receptor, 03 medical and health sciences, chemistry.chemical_compound, Antineoplastic Agents, Immunological, 0302 clinical medicine, Immune system, Cancer immunotherapy, Carcinoma, Non-Small-Cell Lung, Carnitine, Biomarkers, Tumor, Humans, Medicine, Prospective Studies, Beta oxidation, Aged, Aged, 80 and over, Glutathione Disulfide, business.industry, Hippurates, Microbiota, General Medicine, Middle Aged, Nivolumab, 030104 developmental biology, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Cancer research, Glutathione disulfide, Drug Therapy, Combination, Female, Immunotherapy, Clinical Medicine, Energy Metabolism, business, CD8

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f8b83c0a144f9febe31ec1f05c62abTest
https://doi.org/10.1172/jci.insight.133501Test

8

Signatures of CD8+ T cell dysfunction in AML patients and their reversibility with response to chemotherapy

المؤلفون: Ivana Gojo, Bruce R. Blazar, Amanda L. Blackford, Rupkatha Mukhopadhyay, Judith E. Karp, Leo Luznik, Hanna A. Knaus, Joshua F. Zeidner, Raul Montiel-Esparza, Sofia Berglund, Katrina Vanura, Hubert Hackl

المصدر: JCI Insight. 3

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, T cell, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Gene Expression, Antineoplastic Agents, CD8-Positive T-Lymphocytes, Lymphocyte Activation, Immunophenotyping, 03 medical and health sciences, Immune system, Cancer immunotherapy, hemic and lymphatic diseases, medicine, Humans, Cytotoxic T cell, Aged, business.industry, Myeloid leukemia, General Medicine, biochemical phenomena, metabolism, and nutrition, Middle Aged, Receptors, OX40, medicine.disease, Up-Regulation, Leukemia, Myeloid, Acute, Leukemia, Ki-67 Antigen, 030104 developmental biology, medicine.anatomical_structure, Cancer research, Cytokines, Female, Immunotherapy, business, CD8, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997c2e4eaa0715c6e73da3c7fec39d69Test
https://doi.org/10.1172/jci.insight.120974Test

9

Frameshift events predict anti–PD-1/L1 response in head and neck cancer

المؤلفون: Ravindra Uppaluri, Jochen H. Lorch, Alexander Frieden, Frank C. Kuo, Glenn J. Hanna, Megan E. Cavanaugh, Jonathan D. Schoenfeld, Patrick H. Lizotte, Robert I. Haddad, Nicole G. Chau, Laura E. MacConaill, Priyanka Shivdasani

المصدر: JCI Insight, Vol 3, Iss 4 (2018)

مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Biopsy, medicine.medical_treatment, DNA Mutational Analysis, Programmed Cell Death 1 Receptor, lcsh:Medicine, B7-H1 Antigen, Antineoplastic Agents, Immunological, 0302 clinical medicine, Mutation Rate, Genes, Tumor Suppressor, Prospective Studies, Frameshift Mutation, Prospective cohort study, Aged, 80 and over, General Medicine, Middle Aged, Prognosis, Neoadjuvant Therapy, Treatment Outcome, medicine.anatomical_structure, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Female, Research Article, Adult, medicine.medical_specialty, T cell, Frameshift mutation, Young Adult, 03 medical and health sciences, Internal medicine, Biomarkers, Tumor, Genetics, medicine, Humans, Survival analysis, Aged, Chemotherapy, Squamous Cell Carcinoma of Head and Neck, business.industry, lcsh:R, Head and neck cancer, Immunotherapy, medicine.disease, Survival Analysis, Otorhinolaryngologic Surgical Procedures, 030104 developmental biology, Drug Resistance, Neoplasm, business, CD8

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d14182187ffb2939faf895230365f8bTest
https://doi.org/10.1172/jci.insight.98811Test

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