The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia
| العنوان: | The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia |
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| المؤلفون: | Roberto Giorda, Vittoria Trezzi, Ginette Dionne, Bei Feng, Andrea Facoetti, Chiara Andreola, Valentina Riva, Sara Mascheretti, Cecilia Marino, Simone Gori, Marco Villa |
| المساهمون: | IRCCS E. Medea, LAVAL UNIVERSITY QUEBEC CAN, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Laboratoire de psychologie du développement et de l'éducation de l'enfant (LaPsyDÉ - UMR 8240), Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), University of Bergamo, Departments of Psychology and Psychiatry, University of Toronto, Toronto, Centre for Addiction and Mental Health [Toronto] (CAMH), University of Padua |
| المصدر: | Brain Sciences, Vol 10, Iss 993, p 993 (2020) Brain Sciences Brain Sciences, MDPI, 2020, 10, ⟨10.3390/brainsci10120993⟩ Brain Sciences; Volume 10; Issue 12; Pages: 993 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Settore M-PSI/01 - Psicologia Generale, Mediation (statistics), Candidate gene, media_common.quotation_subject, Article, lcsh:RC321-571, 03 medical and health sciences, 0302 clinical medicine, DCDC2, Reading (process), medicine, Candidate genes, Developmental dyslexia, Endophenotypes, Mediation, Multisensory temporal processing, mediation, Rapid automatized naming, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, 030304 developmental biology, media_common, 0303 health sciences, biology, General Neuroscience, [SCCO.NEUR]Cognitive science/Neuroscience, Dyslexia, multisensory temporal processing, medicine.disease, developmental dyslexia, endophenotypes, Endophenotype, [SCCO.PSYC]Cognitive science/Psychology, biology.protein, GRIN2B, Psychology, candidate genes, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Although substantial heritability has been reported and candidate genes have been identified, we are far from understanding the etiopathogenetic pathways underlying developmental dyslexia (DD). Reading-related endophenotypes (EPs) have been established. Until now it was unknown whether they mediated the pathway from gene to reading (dis)ability. Thus, in a sample of 223 siblings from nuclear families with DD and 79 unrelated typical readers, we tested four EPs (i.e., rapid auditory processing, rapid automatized naming, multisensory nonspatial attention and visual motion processing) and 20 markers spanning five DD-candidate genes (i.e., DYX1C1, DCDC2, KIAA0319, ROBO1 and GRIN2B) using a multiple-predictor/multiple-mediator framework. Our results show that rapid auditory and visual motion processing are mediators in the pathway from ROBO1-rs9853895 to reading. Specifically, the T/T genotype group predicts impairments in rapid auditory and visual motion processing which, in turn, predict poorer reading skills. Our results suggest that ROBO1 is related to reading via multisensory temporal processing. These findings support the use of EPs as an effective approach to disentangling the complex pathways between candidate genes and behavior. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-3425 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d56b7944dd3dbc8557b64a291072a73Test https://www.mdpi.com/2076-3425/10/12/993Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3d56b7944dd3dbc8557b64a291072a73 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763425 |
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