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المؤلفون: Valeria Napolitano, Agnieszka Dabrowska, Kenji Schorpp, André Mourão, Emilia Barreto-Duran, Malgorzata Benedyk, Pawel Botwina, Stefanie Brandner, Mark Bostock, Yuliya Chykunova, Anna Czarna, Grzegorz Dubin, Tony Fröhlich, Michael Hölscher, Malwina Jedrysik, Alex Matsuda, Katarzyna Owczarek, Magdalena Pachota, Oliver Plettenburg, Jan Potempa, Ina Rothenaigner, Florian Schlauderer, Klaudia Slysz, Artur Szczepanski, Kristin Greve-Isdahl Mohn, Bjorn Blomberg, Michael Sattler, Kamyar Hadian, Grzegorz Maria Popowicz, Krzysztof Pyrc
المصدر: Cell Chemical Biology
Cell chemical biology 29 (2022), Nr. 5
Cell chemical biology
Cell Chem. Bio. 29, 774-784.e8 (2022)مصطلحات موضوعية: Dewey Decimal Classification::500 | Naturwissenschaften::540 | Chemie, Dewey Decimal Classification::500 | Naturwissenschaften::570 | Biowissenschaften, Biologie, Clinical Biochemistry, coronavirus, Biochemistry, acriflavine, Antiviral Agents, Article, protease inhibitor, Mice, ddc:570, Drug Discovery, structural biology, Animals, Humans, Molecular Biology, Pandemics, Pharmacology, drug repurposing, SARS-CoV-2, COVID-19, protease, COVID-19 Drug Treatment, Molecular Docking Simulation, PLpro, Covid-19, Pl(pro), Sars-cov-2, Acriflavine, Coronavirus, Drug Repurposing, Protease, Protease Inhibitor, Structural Biology, ddc:540, Molecular Medicine
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531edc41a740649bff0588acda8eaf23Test
http://europepmc.org/articles/PMC8751734Test -
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المؤلفون: U. Helena Danielson, Helena Nordström, Tom Dzus, Valeria Napolitano, Giulia Opassi, Gerhard Klebe, Arne Lundin, Francesca Magari
المصدر: Protein Science
Protein Science : A Publication of the Protein Societyمصطلحات موضوعية: Chagas disease, Thermal shift assay, Trypanosoma cruzi, Fragment-based lead discovery, Farnesyl pyrophosphate, SPR, Biochemistry, Pyrophosphate, Catalysis, Article, Cofactor, 03 medical and health sciences, chemistry.chemical_compound, Magnesium, Luciferase, Molecular Biology, 030304 developmental biology, 0303 health sciences, biology, 030302 biochemistry & molecular biology, Biochemistry and Molecular Biology, Geranyltranstransferase, fragment screening, Articles, Surface Plasmon Resonance, binding efficiency, biology.organism_classification, farnesyl pyrophosphate synthase, chemistry, biology.protein, Target protein, Biokemi och molekylärbiologi
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4244925221396853671363436167464eTest
https://doi.org/10.1002/pro.3834Test -
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المؤلفون: Grzegorz M Popowicz, Jos Buijs, Valeria Napolitano, Giulia Opassi, U. Helena Danielson, Hanna Björkelund, Grzegorz Dubin, João Crispim Encarnação, Hélène Munier-Lehmann, Karl Andersson
المساهمون: Ridgeview Instruments AB [Uppsala, Sueden], Department of Immunology, Genetics and Pathology [Uppsala, Sueden] (IGP), Uppsala University, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Department of Chemistry [Uppsala, Sueden], Biomedical Center = Biomedicinskt centrum [Uppsala, Sueden] (BMC), Uppsala University-Uppsala University, Malopolska Centre of Biotechnology [Krakow] (MCB), Helmholtz-Zentrum München (HZM), Center for Integrated Protein Science (CIPSM), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Helmholtz-Zentrum München (HZM)-Ludwig Maximilian University of Munich [Germany] (LMU München), Chimie et Biocatalyse, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], This project has received funding from the European Union's Framework Programme for Research and Innovation Horizon 2020 (2014–2020) under the Marie Sklodowska‐Curie Grant Agreement No. 675555, Accelerated Early staGe drug discovery (AEGIS)., Microscopic imaging was performed with equipment maintained by the BioVis Platform at Uppsala University. We thank to Dr Arie Geerlof and Dr André Mourão (Institute of Structural Biology, Helmholtz Zentrum München) for providing help on protein expression and purification of the STxB constructs., European Project: 675555,H2020,H2020-MSCA-ITN-2015,AEGIS(2016), Helmholtz Zentrum München = German Research Center for Environmental Health, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Ludwig-Maximilians-Universität München (LMU)-Helmholtz Zentrum München = German Research Center for Environmental Health, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
المصدر: FEBS Lett. 594, 2406-2420 (2020)
FEBS Letters
FEBS Letters, Wiley, 2020, 594 (15), pp.2406-2420. ⟨10.1002/1873-3468.13847⟩
FEBS Letters, 2020, 594 (15), pp.2406-2420. ⟨10.1002/1873-3468.13847⟩مصطلحات موضوعية: media_common.quotation_subject, [SDV]Life Sciences [q-bio], Cell, education, Biophysics, Globotriaosylceramide, cell surface receptor, Biological Transport, Active, Shiga Toxins, Biochemistry, real-time cell-binding assays, 03 medical and health sciences, chemistry.chemical_compound, [SPI]Engineering Sciences [physics], Structural Biology, Cell surface receptor, receptor internalization, Neoplasms, Genetics, medicine, binding kinetics, cancer, Humans, Internalization, Molecular Biology, Binding Kinetics, Cancer, Cell Surface Receptor, Real-time Cell-binding Assays, Receptor Internalization, Shiga Toxin, real-time cell- binding assays, 030304 developmental biology, media_common, 0303 health sciences, Drug Carriers, Chemistry, Trihexosylceramides, 030302 biochemistry & molecular biology, Biochemistry and Molecular Biology, Cell Biology, Shiga toxin, Small molecule, Receptor–ligand kinetics, 3. Good health, Cell biology, ddc, medicine.anatomical_structure, Cancer cell, Biological Assay, K562 Cells, HT29 Cells, Intracellular, Biokemi och molekylärbiologi
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4182f413821e2c51a52d6f7a9bf9a7ffTest
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=59243Test -
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المساهمون: Troisi, Romualdo, Napolitano, Valeria, Spiridonova, Vera, RUSSO KRAUSS, Irene, Sica, Filomena
المصدر: 'Nucleic Acids Research ', vol: 46, pages: 12177-12185 (2018)
Nucleic Acids Researchمصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, Aptamer, Amino Acid Motifs, Oligonucleotides, Plasma protein binding, 030204 cardiovascular system & hematology, Biology, Crystallography, X-Ray, Ligands, G-quadruplex, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Thrombin, Fibrinolytic Agents, Structural Biology, Hydrolase, Genetics, medicine, Humans, Structural motif, Circular Dichroism, Anticoagulants, Fibrinogen, Aptamers, Nucleotide, G-Quadruplexes, 030104 developmental biology, Duplex (building), Mutation, Biophysics, Protein Binding, medicine.drug
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c3e57bb79b2ce1b21f355c0f7ab9d3Test
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:51073Test -
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المساهمون: RUSSO KRAUSS, Irene, Vera, Spiridonova, Pica, Andrea, Napolitano, Valeria, Sica, Filomena
المصدر: Nucleic Acids Research
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Aptamer, Biology, Bioinformatics, G-quadruplex, Crystallography, X-Ray, Thrombin, apamer ,auplex/quadruplex, junction, anticoagulan sctivity, crystal structure, 03 medical and health sciences, Thrombin, Structural Biology, Hydrolase, Genetics, medicine, heterocyclic compounds, Hydrogen bond, Oligonucleotide, Hydrogen Bonding, Aptamers, Nucleotide, G-Quadruplexes, 030104 developmental biology, Duplex (building), Biophysics, Nucleic Acid Conformation, Corrigendum, Anti-thrombin aptamers, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08d8c07af166d65d2fbecdbf9b2a50cTest
https://pubmed.ncbi.nlm.nih.gov/31095328Test -
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المصدر: Nucleic Acids Research. 44:3969-3969
مصطلحات موضوعية: Genetics
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7086d5960158af6ac2387c03f4a9666bTest
https://doi.org/10.1093/nar/gkw078Test
