المؤلفون: Sarton, Benjamine, Tauber, Clovis, Fridman, Estéban, Péran, Patrice, Riu, Beatrice, Vinour, Hélène, David, Adrian, Geeraerts, Thomas, Bounes, Fanny, Minville, Vincent, Delmas, Clément, Salabert, Anne-Sophie, Albucher, Jean, François, Bataille, Benoit, Olivot, Jean, Marc, Cariou, Alain, Naccache, Lionel, Payoux, Pierre, Schiff, Nicholas, Silva, Stein

المساهمون: Toulouse NeuroImaging Center (ToNIC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Toulouse Mind & Brain Institut (TMBI), Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université Toulouse - Jean Jaurès (UT2J), Université de Toulouse (UT)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Pôle Anesthésie Réanimation CHU de Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Imaging, Brain & Neuropsychiatry (iBraiN), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Weill Medical College of Cornell University New York, Pôle Neurosciences CHU Toulouse, Service Cardiologie CHU Toulouse, Pôle Cardiovasculaire et Métabolique CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Département Neurologie CHU Toulouse, Centre Hospitalier de Narbonne (CH Narbonne), Hôpital Cochin AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Equipe Neuropsychologie et neuroimagerie fonctionnelle ICM Paris (PICNIC), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 0006-8950.

مصطلحات موضوعية: disorders of consciousness, neuroimmune activation, TSPO PET scan, prognosis, traumatic brain injury, brain anoxia, mesocircuit, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]

الوصف: International audience ; The pathophysiological underpinnings of critically disrupted brain connectomes resulting in coma are poorly understood, but inflammation is potentially an important but still undervalued factor. Here we present a first-in-human prospective study using translocator protein 18 kDa (TSPO) radioligand (F18-DPA714) for PET imaging, to allow in vivo neuroimmune activation quantification on patients with coma (n = 17) following either anoxia or traumatic brain injuries and compare with age and sex-matched controls. Our findings yield novel evidence that an early inflammatory component that is predominantly located within key cortical and subcortical brain structures which are putatively implicated in consciousness emergence and maintain after severe brain injury (i.e. mesocircuit and frontoparietal networks). We observed that traumatic and anoxic patients with coma have distinct neuroimmune activation profiles, both in terms of intensity and spatial distribution. Finally, we demonstrated that both the total amount and the specifically distributed PET-measurable neuroinflammation within the brain mesocircuit were associated with patient’s potential of recovery. We suggest that our results can be developed for use both as a new neuroprognostication tool and as promising biometric to guide future clinical trials targeting glial activity very early after severe brain injury.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38412555; hal-04508517; https://hal.science/hal-04508517Test; https://hal.science/hal-04508517/documentTest; https://hal.science/hal-04508517/file/Sarton_2024.pdfTest; PUBMED: 38412555

الإتاحة: https://doi.org/10.1093/brain/awae045/7615245Test
https://hal.science/hal-04508517Test
https://hal.science/hal-04508517/documentTest
https://hal.science/hal-04508517/file/Sarton_2024.pdfTest

المؤلفون: Gros, Alexandre, Seguy, Benjamin, Bonnet, Guillaume, Guettard, Yves-Olivier, Pillois, Xavier, Prevel, Renaud, Orieux, Arthur, Ternacle, Julien, Préau, Sebastien, Lavie-Badie, Yoan, Coupez, Elisabeth, Coudroy, Rémi, Marest, Delphine, Martins, Raphaël P., Gruson, Didier, Tourdias, Thomas, Boyer, Alexandre, Coste, Pierre, Fukutomi, Hikaru, Souweine, Bertrand, Preau, Sébastien, Nseir, Saad, Toussaint, Aurélia, Outteryck, Olivier, Reignier, Jean, Robert, René, Martins, Raphaël, Urien, Jean Marie, Porte, Lydie, Robin, Guillaume, Charbonnier, Gaëtan, Sarton, Benjamine, Silva, Stein

المصدر: Annals of Intensive Care ; volume 14, issue 1 ; ISSN 2110-5820

مصطلحات موضوعية: Critical Care and Intensive Care Medicine

الوصف: Background The benefit–risk balance and optimal timing of surgery for severe infective endocarditis (IE) with ischemic or hemorrhagic strokes is unknown. The study aim was to compare the neurological outcome between patients receiving surgery or not. Methods In a prospective register-based multicenter ICU study, patients were included if they met the following criteria: (i) left-sided IE with an indication for heart surgery; (ii) with cerebral complications documented by cerebral imaging before cardiac surgery; (iii) with Sequential Organ Failure Assessment score ≥ 3. Exclusion criteria were isolated right-sided IE, in-hospital acquired IE and patients with cerebral complications only after cardiac surgery. In the primary analysis, the prognostic value of surgery in term of disability at 6 month was assessed by using a propensity score-adjusted logistic regression. Results 192 patients were included including ischemic stroke (74.5%) and hemorrhagic lesion (15.6%): 67 (35%) had medical treatment and 125 (65%) cardiac surgery. In the propensity score-adjusted logistic regression, a favorable 6-month neurological outcome was associated with surgery (odds ratio 13.8 (95% CI 6.2–33.7). The 1-year mortality was strongly reduced with surgery in the fixed-effect propensity-adjusted Cox model (hazard ratio 0.18; 95% CI 0.11–0.27; p < 0.001). These effects remained whether the patients received delayed surgery ( n = 62/125) or not and whether they were deeply comatose (Glasgow Coma Scale ≤ 10) or not. Conclusions In critically ill IE patients with an indication for surgery and previous cerebral events, a better propensity-adjusted neurological outcome was associated with surgery compared with medical treatment.

الإتاحة: https://doi.org/10.1186/s13613-023-01221-xTest

المؤلفون: Karakuş, Oktay, Anantrasirichai, Nantheera, Aguersif, Amazigh, Silva, Stein, Basarab, Adrian, Achim, Alin

مصطلحات موضوعية: Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Computer Vision and Pattern Recognition, Electrical Engineering and Systems Science - Signal Processing

الوصف: In this paper, we present a novel method for line artefacts quantification in lung ultrasound (LUS) images of COVID-19 patients. We formulate this as a non-convex regularisation problem involving a sparsity-enforcing, Cauchy-based penalty function, and the inverse Radon transform. We employ a simple local maxima detection technique in the Radon transform domain, associated with known clinical definitions of line artefacts. Despite being non-convex, the proposed technique is guaranteed to convergence through our proposed Cauchy proximal splitting (CPS) method and accurately identifies both horizontal and vertical line artefacts in LUS images. In order to reduce the number of false and missed detection, our method includes a two-stage validation mechanism, which is performed in both Radon and image domains. We evaluate the performance of the proposed method in comparison to the current state-of-the-art B-line identification method and show a considerable performance gain with 87% correctly detected B-lines in LUS images of nine COVID-19 patients. In addition, owing to its fast convergence, our proposed method is readily applicable for processing LUS image sequences.
Comment: 16 pages, 9 figures

الوصول الحر: http://arxiv.org/abs/2005.03080Test

المؤلفون: Cariou, Erwann, Griffier, Romain, Orieux, Arthur, Silva, Stein, Faguer, Stanislas, Seguin, Thierry, Nseir, Saad, Canet, Emmanuel, Desclaux, Arnaud, Souweine, Bertrand, Klouche, Kada, Guisset, Olivier, Pillot, Jérôme, Picard, Walter, Saghi, Tahar, Delobel, Pierre, Gruson, Didier, Prével, Renaud, Boyer, Alexandre

المساهمون: Centre Hospitalier Universitaire de Bordeaux (CHU de Bordeaux), Santé publique, Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche Cardio-Thoracique de Bordeaux Bordeaux (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Département de Néphrologie et Transplantation d'organes CHU Toulouse, Pôle Urologie - Néphrologie - Dialyse - Transplantations - Brûlés - Chirurgie plastique - Explorations fonctionnelles et physiologiques CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Faculté de Médecine Rangueil, Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Service de médecine interne et maladies tropicales, CHU Bordeaux-Groupe hospitalier Saint-André, CHU Gabriel Montpied Clermont-Ferrand, CHU Clermont-Ferrand, Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), CHU Montpellier, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Centre Hospitalier de la Côte Basque (CHCB), Centre hospitalier de Pau, Polyclinique Bordeaux Nord Aquitaine (PBNA), Service Maladies infectieuses et tropicales CHU Toulouse, Pôle Inflammation, infection, immunologie et loco-moteur CHU Toulouse (Pôle I3LM Toulouse)

المصدر: ISSN: 2110-5820 ; Annals of Intensive Care ; https://hal.science/hal-04046566Test ; Annals of Intensive Care, 2023, 13 (1), pp.22. ⟨10.1186/s13613-023-01106-z⟩.

مصطلحات موضوعية: Extended-spectrum β-lactamase-producing Enterobacterales, Non carbapenem β-lactam therapy, Antimicrobial resistance, Septic shock, Urinary tract infection, Aminoglycosides, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie

الوصف: International audience ; Abstract Background The rise in antimicrobial resistance is a global threat responsible for about 33,000 deaths in 2015 with a particular concern for extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) and has led to a major increase in the use of carbapenems, last-resort antibiotics. Methods In this retrospective propensity-weighted multicenter observational study conducted in 11 ICUs, the purpose was to assess the efficacy of non carbapenem regimen (piperacillin–tazobactam (PTZ) + aminoglycosides or 3rd-generation cephalosporin (3GC) + aminoglycosides) as empiric therapy in comparison with carbapenem in extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) urinary septic shock. The primary outcome was Day-30 mortality. Results Among 156 patients included in this study, 69 received a carbapenem and 87 received non carbapenem antibiotics as empiric treatment. Baseline clinical characteristics were similar between the two groups. Patients who received carbapenem had similar Day-30 mortality (10/69 (15%) vs 6/87 (7%), OR = 1.99 [0.55; 5.34] p = 0.16), illness severity, resolution of septic shock, and ESBL-E infection recurrence rates than patients who received an empiric non carbapenem therapy. The rates of secondary infection with C. difficile were comparable. Conclusions In ESBL-E urinary septic shock, empiric treatment with a non carbapenem regimen, including systematically aminoglycosides, was not associated with higher mortality, compared to a carbapenem regimen.

العلاقة: hal-04046566; https://hal.science/hal-04046566Test; https://hal.science/hal-04046566/documentTest; https://hal.science/hal-04046566/file/2023%20Cariou%20et%20al.,%20Efficacy%20of%20carbapenem%20vs%20non%20carbapenem%20%CE%B2.pdfTest

الإتاحة: https://doi.org/10.1186/s13613-023-01106-zTest
https://hal.science/hal-04046566Test
https://hal.science/hal-04046566/documentTest
https://hal.science/hal-04046566/file/2023%20Cariou%20et%20al.,%20Efficacy%20of%20carbapenem%20vs%20non%20carbapenem%20%CE%B2.pdfTest

المؤلفون: Tabah, Alexis, Buetti, Niccolò, Staiquly, Quentin, Ruckly, Stéphane, Akova, Murat, Aslan, Abdullah Tarik, Leone, Marc, Conway Morris, Andrew, Bassetti, Matteo, Arvaniti, Kostoula, Lipman, Jeffrey, Ferrer, Ricard, Qiu, Haibo, Paiva, José-Artur, Povoa, Pedro, de Bus, Liesbet, de Waele, Jan, Zand, Farid, Gurjar, Mohan, Alsisi, Adel, Abidi, Khalid, Bracht, Hendrik, Hayashi, Yoshiro, Jeon, Kyeongman, Elhadi, Muhammed, Barbier, François, Timsit, Jean-François, Pollock, Hamish, Margetts, Ben, Young, Meredith, Bhadange, Neeraj, Tyler, Steven, Ledtischke, Anne, Finnis, Mackenzie, Dwivedi, Jyotsna, Saxena, Manoj, Biradar, Vishwanath, Soar, Natalie, Sarode, Vineet, Brewster, David, Regli, Adrian, Weeda, Elizabeth, Ahmed, Samiul, Fourie, Cheryl, Laupland, Kevin, Ramanan, Mahesh, Walsham, James, Meyer, Jason, Litton, Edward, Palermo, Anna Maria, Yap, Timothy, Eroglu, Ege, Attokaran, Antony George, Jaramillo, C’havala, Nafees, Khalid Mahmood Khan, Rashid, Nurhikmahtul Aqilah Haji Abd, Walid, Haji Adi Muhamad Ibnu, Mon, Tomas, Moorthi, P. Dhakshina, Sudhirchandra, Shah, Sridharan, Dhadappa Damodar, Haibo, Qiu, Jianfeng, Xie, Wei-Hua, Lu, Zhen, Wang, Qian, Chuanyun, Luo, Jili, Chen, Xiaomei, Wang, Hao, Zhao, Peng, Zhao, Juan, Wusi, Qiu, Mingmin, Chen, Xu, Lei, Yin, Chengfen, Wang, Ruilan, Wang, Jinfeng, Yin, Yongjie, Zhang, Min, Ye, Jilu, Hu, Chungfang, Zhou, Suming, Huang, Min, Yan, Jing, Wang, Yan, Qin, Bingyu, Ye, Ling, Weifeng, Xie, Peije, Li, Geng, Nan, Karumai, Toshiyuki, Yamasaki, Masaki, Hashimoto, Satoru, Hosokawa, Koji, Makino, Jun, Matsuyoshi, Takeo, Kuriyama, Akira, Shigemitsu, Hidenobu, Mishima, Yuka, Nagashima, Michio, Yoshida, Hideki, Fujitani, Shigeki, Omori, Koichiro, Rinka, Hiroshi, Saito, Hiroki, Atobe, Kaori, Kato, Hideaki, Takaki, Shunsuke, Hasan, M. Shahnaz, Jamaluddin, Muhamad Fadhil Hadi, Pheng, Lee See, Visvalingam, Sheshendrasurian, Liew, Mun Thing, Wong, Siong Ling Danny, Fong, Kean Khang, Rahman, Hamizah Bt Abdul, Noor, Zuraini Md, Tong, Lee Kok, Azman, Abd. Hamid, Mazlan, Mohd Zulfakar, Ali, Saedah, Lee, Sang-Min, Park, Sunghoon, Park, Seung Yong, Lim, Sung Yoon, Goh, Qing Yuan, Ng, Shin Yi, Lie, Sui An, Kwa, Andrea Lay Hoon, Goh, Ken Junyang, Li, Andrew Yunkai, Ong, Caroline Yu Ming, Lim, Jia Yan, Quah, Jessica Lishan, Ng, Kangqi, Ng, Louis Xiang Long, Yeh, Yu Chang, Chou, Nai-Kuan, Cia, Cong-Tat, Hu, Ting-Yu, Kuo, Li-Kuo, Ku, Shih-Chi, Wongsurakiat, Phunsup, Apichatbutr, Yutthana, Chiewroongroj, Supattra, Nadeem, Rashid, Houfi, Ashraf El, Elhadidy, Amr, Barsoum, Mina, Osman, Nermin, Mostafa, Tarek, Elbahnasawy, Mohamed, Saber, Ahmed, Aldhalia, Amer, Elmandouh, Omar, Elsayed, Ahmed, Elbadawy, Merihan, Awad, Ahmed, Hemead, Hanan, Ouhadian, Maryam, Borsi, Seyed Hamid, Mehraban, Zahra, Kashipazha, Davood, Ahmadi, Fatemeh, Savaie, Mohsen, Soltani, Farhad, Rashidi, Mahboobeh, Baghbanian, Reza, Javaherforoosh, Fatemeh, Amiri, Fereshteh, Kiani, Arash, Zargar, Mohammad Amin, Mahmoodpoor, Ata, Aalinezhad, Fatemeh, Dabiri, Gholamreza, Sabetian, Golnar, Sarshad, Hakimeh, Masjedi, Mansoor, Tajvidi, Ramin, Tabatabaei, Seyed Mohammad Nasirodin, Ahmed, Abdullah Khudhur, Singer, Pierre, Kagan, Ilya, Rigler, Merav, Belman, Daniel, Levin, Phillip, Harara, Belal, Diab, Adei, Abilama, Fayez, Ibrahim, Rebecca, Fares, Aya, Buimsaedah, Ahmad, Gamra, Marwa, Aqeelah, Ahmed, Aliali, Almajdoub Mohammed, Homaidan, Ahmed Gaber Sadik, Almiqlash, Bushray, Bilkhayr, Hala, Bouhuwaish, Ahmad, Taher, Ahmed Sa, Abdulwahed, Eman, Abousnina, Fathi, Hdada, Aisha Khaled, Jobran, Rania, Hasan, Hayat Ben, Hasan, Rabab Shaban Ben, Serghini, Issam, Seddiki, Rachid, Boukatta, Brahim, Kanjaa, Nabil, Mouhssine, Doumiri, Wajdi, Maazouzi Ahmed, Dendane, Tarek, Zeggwagh, Amine Ali, Housni, Brahim, Younes, Oujidi, Hachimi, Abdelhamid, Ghannam, A., Belkhadir, Z., Amro, Sarah, Jayyab, Mustafa Abu, Hssain, Ali Ait, Elbuzidi, Abdurahaman, Karic, Edin, Lance, Marcus, Nissar, Shaikh, Sallam, Hend, Elrabi, Omar, Almekhlafi, Ghaleb, Awad, Maher, Aljabbary, Ahmed, Chaaban, Mohammad Karam, Abu-Sayf, Natalia, Al-Jadaan, Mohammad, Bakr, Lubna, Bouaziz, Mounir, Turki, Olfa, Sellami, Walid, Centeno, Pablo, Morvillo, Lic Natalia, Acevedo, José Oscar, Lopez, Patricia Mabel, Fernández, Rubén, Segura, Matías, Aparicio, Dra Marta, Alonzo, Microbiologa Irene, Nuccetelli, Yanina, Montefiore, Pablo, Reyes, Luis Felipe, Ñamendys-Silva, Silvio, Romero-Gonzalez, Juan, Hermosillo, Mariana, Castillo, Roberto Alejandro, Leal, Jesús Nicolás Pantoja, Aguilar, Candy Garcia, Herrera, Mara Ocotlan Gonzalez, Villafuerte, Missael Vladimir Espinoza, Lomeli-Teran, Manuel, Dominguez-Cherit, Jose, Davalos-Alvarez, Adrian, Sánchez-Hurtado, Luis, Tejeda-Huezo, Brigitte, Perez-Nieto, Orlando, Tomas, Ernesto Deloya, Hollevoet, Isabelle, Denys, Wouter, Bourgeois, Marc, Vanderhaeghen, Sofie, Mesland, Jean-Baptiste, Henin, Pierre, Haentjens, Lionel, Biston, Patrick, Noel, Cindérella, Layos, Nathalie, Misset, Benoît, de Schryver, Nicolas, Serck, Nicolas, Wittebole, Xavier, de Waele, Elisabeth, Opdenacker, Godelive, Kovacevic, Pedja, Zlojutro, Biljana, Custovic, Aida, Filipovic-Grcic, Ina, Radonic, Radovan, Brajkovic, Ana Vujaklija, Persec, Jasminka, Sakan, Sanja, Nikolic, Mario, Lasic, Hrvoje, Arbelot, Charlotte, Patrier, Juliette, Zappela, N., Montravers, P., Dulac, Thierry, Castanera, Jérémy, Auchabie, Johann, Le Meur, Anthony, Marchalot, A., Beuzelin, M., Massri, Alexandre, Guesdon, Charlotte, Escudier, Etienne, Mateu, Philippe, Rosman, Jérémy, Leroy, Olivier, Alfandari, Serge, Nica, Alexandru, Souweine, Bertrand, Coupez, Elisabeth, Duburcq, Thibault, Kipnis, Eric, Bortolotti, Perrine, Le Souhaitier, Mathieu, Mira, Jean-Paul, Garcon, Pierre, Duprey, Matthieu, Thyrault, Martial, Paulet, Rémi, Philippart, François, Tran, Marc, Bruel, Cédric, Weiss, Emmanuel, Janny, Sylvie, Foucrier, Arnaud, Perrigault, Pierre-François, Djanikian, Flora, Gainnier, Marc, Bourenne, Jérémy, Louis, Guillaume, Smonig, Roland, Argaud, Laurent, Baudry, Thomas, Dessap, Armand Mekonted, Razazi, Keyvan, Kalfon, Pierre, Badre, Gaëtan, Larcher, Romaric, Lefrant, Jean-Yves, Roger, Claire, Sarton, Benjamine, Silva, Stein, Demeret, Sophie, Le Guennec, Loïc, Siami, Shidasp, Aparicio, Christelle, Voiriot, Guillaume, Fartoukh, Muriel, Dahyot-Fizelier, Claire, Imzi, Nadia, Klouche, Kada, Hoheisen, Sandra, Bloos, Frank, Thomas-Rueddel, Daniel, Petros, Sirak, Pasieka, Bastian, Dubler, Simon, Schmidt, Karsten, Gottschalk, Antje, Wempe, Carola, Lepper, Philippe, Metz, Carlos, Viderman, Dmitriy, Ymbetzhanov, Yerlan, Mugazov, Miras, Bazhykayeva, Yelena, Kaligozhin, Zhannur, Babashev, Baurzhan, Merenkov, Yevgeniy, Temirov, Talgat, Smyrniotis, Dimitrios, Psallida, Vasiliki, Fildisis, Georgios, Soulountsi, Vasiliki, Kaimakamis, Evangelos, Iasonidou, Cristina, Papoti, Sofia, Renta, Foteini, Vasileiou, Maria, Romanou, Vasiliki, Koutsoukou, Vasiliki, Matei, Mariana Kristina, Moldovan, Leora, Karaiskos, Ilias, Paskalis, Harry, Marmanidou, Kyriaki, Papanikolaou, M., Kampolis, C., Oikonomou, Marina, Kogkopoulos, Evangelos, Nikolaou, Charikleia, Sakkalis, Anastasios, Chatzis, Marinos, Georgopoulou, Maria, Efthymiou, Anna, Chantziara, Vasiliki, Sakagianni, Aikaterini, Athanasa, Zoi, Papageorgiou, Eirini, Ali, Fadi, Dimopoulos, Georges, Almiroudi, Mariota Panagiota, Malliotakis, Polychronis, Marouli, Diamantina, Theodorou, Vasiliki, Retselas, Ioannis, Kouroulas, Vasilios, Papathanakos, Georgios, Montrucchio, Giorgia, Sales, Gabriele, de Pascale, Gennaro, Montini, Luca Maria, Carelli, Simone, Vargas, Joel, Di Gravio, Valentina, Giacobbe, Daniele Roberto, Gratarola, Angelo, Porcile, Elisa, Mirabella, Michele, Daroui, Ivan, Lodi, Giovanni, Zuccaro, Francesco, Schlevenin, Maria Grazia, Pelosi, Paolo, Battaglini, Denise, Cortegiani, Andrea, Ippolito, Mariachiara, Bellina, Davide, Di Guardo, Andrea, Pelagalli, Lorella, Covotta, Marco, Rocco, Monica, Fiorelli, Silvia, Cotoia, Antonella, Rizzo, Anna Chiara, Mikstacki, Adam, Tamowicz, Barbara, Komorowska, Irmina Kaptur, Szczesniak, Anna, Bojko, Jozef, Kotkowska, Anna, Walczak-Wieteska, Paulina, Wasowska, Dominika, Nowakowski, Tomasz, Broda, Hanna, Peichota, Mariusz, Pietraszek-Grzywaczewska, Iwona, Martin-Loeches, Ignacio, Bisanti, Alessandra, Cartoze, Nuno, Pereira, Tiago, Guimarães, Nádia, Alves, Madalena, Marques, Ana Josefina Pinheiro, Pinto, Ana Rios, Krystopchuk, Andriy, Teresa, Ana, de Figueiredo, António Manuel Pereira, Botelho, Isabel, Duarte, Tiago, Costa, Vasco, Cunha, Rui Pedro, Molinos, Elena, da Costa, Tito, Ledo, Sara, Queiró, Joana, Pascoalinho, Dulce, Nunes, Cristina, Moura, José Pedro, Pereira, Énio, Mendes, António Carvalho, Valeanu, Liana, Bubenek-Turconi, Serban, Grintescu, Ioana Marina, Cobilinschi, Cristian, Filipescu, Daniela Carmen, Predoi, Cornelia Elena, Tomescu, Dana, Popescu, Mihai, Marcu, Alexandra, Grigoras, Ioana, Lungu, Olguta, Gritsan, Alexey, Anderzhanova, Anastasia, Meleshkina, Yulia, Magomedov, Marat, Zubareva, Nadezhda, Tribulev, Maksim, Gaigolnik, Denis, Eremenko, Aleksandr, Vistovskaya, Natala, Chukina, Maria, Belskiy, Vladislav, Furman, Mikhail, Rocca, Ricard Ferrer, Martinez, Maria, Casares, Vanessa, Vera, Paula, Flores, Matias, Amerigo, Joaquin Amador, Arnillas, Maria Pilar Gracia, Bermudez, Rosana Munoz, Armestar, Fernando, Catalan, Beatriz, Roig, Regina, Raguer, Laura, Quesada, María Dolores, Santos, Emilio Diaz, Gomà, Gemma, Ubeda, Alejandro, Salgado, Dra Maria, Espina, Lorena Forcelledo, Prieto, Emilio Garcia, Asensio, Dra Mj, Rodriguez, Dra, Maseda, Emilio, de la Rica, Alejandro Suarez, Ayestaran, J. Ignacio, Novo, Mariana, Blasco-Navalpotro, Miguel Angel, Gallego, Alberto Orejas, Sjövall, Fredrik, Spahic, Dzana, Svensson, Carl Johan, Haney, Michael, Edin, Alicia, Åkerlund, Joyce, de Geer, Lina, Prazak, Josef, Jakob, Stephan, Pagani, Jl, Abed-Maillard, S., Timuroglu, Arif, Kocagoz, Sesin, Kusoglu, Hulya, Mehtap, Selcuk, Ceyhun, Solakoğlu, Altintas, Neriman Defne, Talan, Leyla, Kayaaslan, Bircan, Kalem, Ayşe Kaya, Kurt, Ibrahim, Telli, Murat, Ozturk, Barcin, Erol, Çiğdem, Demiray, Emine Kubra Dindar, Çolak, Sait, Akbas, Türkay, Gundogan, Kursat, Sari, Ali, Agalar, Canan, Çolak, Onur, Baykam, Nurcan, Akdogan, Ozlem, Yilmaz, Mesut, Tunay, Burcu, Cakmak, Rumeysa, Saltoglu, Nese, Karaali, Ridvan, Koksal, Iftihar, Aksoy, Firdevs, Eroglu, Ahmet, Saracoglu, Kemal Tolga, Bilir, Yeliz, Guzeldag, Seda, Ersoz, Gulden, Evik, Guliz, Sungurtekin, Hulya, Ozgen, Cansu, Erdoğan, Cem, Gürbüz, Yunus, Altin, Nilgün, Bayindir, Yasar, Ersoy, Yasemin, Goksu, Senay, Akyol, Ahmet, Batirel, Ayse, Aktas, Sabahat Cagan, Morris, Andrew Conway, Routledge, Matthew, Ercole, Ari, Antcliffe, David, Rojo, Roceld, Tizard, Kate, Faulkner, Maria, Cowton, Amanda, Kent, Melanie, Raj, Ashok, Zormpa, Artemis, Tinaslanidis, George, Khade, Reena, Torlinski, Tomasz, Mulhi, Randeep, Goyal, Shraddha, Bajaj, Manan, Soltan, Marina, Yonan, Aimee, Dolan, Rachael, Johnson, Aimee, Macfie, Caroline, Lennard, James, Templeton, Maie, Arias, Sonia Sousa, Franke, Uwe, Hugill, Keith, Angell, Hollie, Parcell, Benjamin, Cobb, Katherine, Cole, Stephen, Smith, Tim, Graham, Clive, Cerman, Jaroslav, Keegan, Allison, Ritzema, Jenny, Sanderson, Amanda, Roshdy, Ashraf, Szakmany, Tamas, Baumer, Tom, Longbottom, Rebecca, Hall, Daniel, Tatham, Kate, Loftus, S., Husain, A., Black, E., Jhanji, S., Baikady, R. Rao, Mcguigan, Peter, Mckee, Rachel, Kannan, Santhana, Antrolikar, Supriya, Marsden, Nicholas, Torre, Valentina Della, Banach, Dorota, Zaki, Ahmed, Jackson, Matthew, Chikungwa, Moses, Attwood, Ben, Patel, Jamie, Tilley, Rebecca, Humphreys, Miss Sally K., Renaud, Paul Jean, Sokhan, Anton, Burma, Yaroslava, Sligl, Wendy, Baig, Nadia, Mccoshen, Lorena, Kutsogiannis, Demetrios, Thompson, Patricia, Hewer, Tayne, Rabbani, Raihan, Huq, Shihan Mahmud Redwanul, Hasan, Rajib, Islam, Mohammad Motiul, Baronia, Arvind, Kothari, Nikhil, Sharma, Ankur, Karmakar, Saurabh, Sharma, Priya, Nimbolkar, Janardan, Samdani, Pratit, Vaidyanathan, R., Rubina, Noor Ahmedi, Jain, Nikhilesh, Pahuja, Madhumati, Singh, Ritu, Shekhar, Saurav, Muzaffar, Syed Nabeel, Ozair, Ahmad, Siddiqui, Suhail Sarwar, Bose, Payel, Datta, Avijatri, Rathod, Darshana, Patel, Mayur, Renuka, M., Baby, Sailaja, Dsilva, Carol, Chandran, Jagadish, Ghosh, Pralay, Mukherjee, Sudipta, Sheshala, Kaladhar, Misra, Krushna Chandra, Yakubu, Saidu Yusuf, Ugwu, Euphemia Mgbosoro, Olatosi, John, Desalu, Ibironke, Asiyanbi, Gabriel, Oladimeji, Motunrayo, Idowu, Olusola, Adeola, Fowotade, Mc Cree, Melanie, Karar, Ali Adil Ali, Saidahmed, Elfayadh, Hamid, Hytham

المساهمون: Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)

المصدر: ISSN: 0342-4642.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

الوصف: International audience

العلاقة: hal-03988471; https://hal.science/hal-03988471Test; https://hal.science/hal-03988471/documentTest; https://hal.science/hal-03988471/file/2023%20Tabah%20et%20al.,%20Epidemiology%20and%20outcomes.pdfTest

الإتاحة: https://doi.org/10.1007/s00134-022-06944-2Test
https://hal.science/hal-03988471Test
https://hal.science/hal-03988471/documentTest
https://hal.science/hal-03988471/file/2023%20Tabah%20et%20al.,%20Epidemiology%20and%20outcomes.pdfTest

المؤلفون: Faucoz, Orphée, Standarovski, Denis, Aguersif, Amazigh, Bouharaoua, Sihem, Sarton, Benjamine, Silva, Stein

المصدر: Critical Care ; volume 27, issue 1 ; ISSN 1364-8535

مصطلحات موضوعية: Critical Care and Intensive Care Medicine

الإتاحة: https://doi.org/10.1186/s13054-022-04219-2Test

المؤلفون: Jeantin, Lina, Dupuis, Claire, Vellieux, Geoffroy, Jaquet, Pierre, de Montmollin, Etienne, Timsit, Jean-François, Sonneville, Romain, Alves, Mikael, Argaud, Laurent, Bailly, Pierre, Barbier, François, Bouadma, Lila, Brulé, Noelle, Bruneel, Fabrice, Chabanne, Russell, Conrad, Marie, da Silva, Daniel, Dailler, Frederic, Daubin, Delphine, Demeret, Sophie, Lerolle, Nicolas, Marechal, Julien, Mourvillier, Bruno, El Kalioubi, Ahmed, Sarton, Benjamine, Silva, Stein, Susset, Vincent, Tadié, Jean Marc, Timsit, Jean-Françoit, Wolff, Michel, Lautrette, Alexandre, Novy, Emmanuel, Guidet, Bertrand, Mateos, François, Brault, Clément, Maestraggi, Quentin, Razazi, Keyvan, Quenot, Jean-Pierre, Joret, Aurélie, Levrat, Albrice, Massri, Alexandre, Robert, Alexandre, Contou, Damien, Mira, Jean-Paul, Stephane, Gaudry, Voiriot, Guillaume, Berger, Asael, Das, Vincent, Engrand, Nicolas, Murgier, Martin

المصدر: Annals of Intensive Care ; volume 13, issue 1 ; ISSN 2110-5820

مصطلحات موضوعية: Critical Care and Intensive Care Medicine

الوصف: Background Electroencephalography (EEG) is recommended for the practical approach to the diagnosis and prognosis of encephalitis. We aimed to investigate the prognostic value of standard EEG ( std EEG) in adult patients with severe herpes simplex encephalitis. Methods We performed a retrospective analysis of consecutive ICU patients with severe herpes simplex encephalitis in 38 French centers between 2006 and 2016. Patients with at least one std EEG study performed at ICU admission were included. std EEG findings were reviewed independently by two investigators. The association between std EEG findings (i.e., background activity, lateralized periodic discharges, seizures/status epilepticus, and reactivity to painful/auditory stimuli) and poor functional outcome, defined by a score on the modified Rankin Scale (mRS) of 3 to 6 (moderate to severe disability or death) at 90 days, were investigated. Results We included 214 patients with at least one available std EEG study. The first std EEG was performed after a median time of one (interquartile range (IQR) 0 to 2) day from ICU admission. At the time of recording, 138 (64.5%) patients were under invasive mechanical ventilation. Lateralized periodic discharges were recorded in 91 (42.5%) patients, seizures in 21 (9.8%) and status epilepticus in 16 (7.5%). In the whole population, reactivity to auditory/noxious stimuli was tested in 140/214 (65.4%) patients and was absent in 71/140 (33.2%) cases. In mechanically ventilated patients, std EEG reactivity was tested in 91/138 (65.9%) subjects, and was absent in 53/91 (58.2%) cases. Absence of reactivity was the only independent std EEG finding associated with poor functional outcome in the whole population (OR 2.80, 95% CI 1.19 to 6.58) and in the subgroup of mechanically ventilated patients (OR 4.99, 95% CI 1.6 to 15.59). Adjusted analyses for common clinical predictors of outcome and sedation at time of std EEG revealed similar findings in the whole population (OR 2.03, 95% CI 1.18 to 3.49) and in mechanically ...

الإتاحة: https://doi.org/10.1186/s13613-023-01110-3Test

المؤلفون: Ferré, Fabrice, Buffières, William, Heine, Lizette, Riu, Beatrice, Curot, Jonathan, Corneyllie, Alexandra, Sarton, Benjamine, Perrin, Fabien, Silva, Stein

المساهمون: French Research National Agency

المصدر: Brain Communications ; volume 5, issue 2 ; ISSN 2632-1297

مصطلحات موضوعية: Neurology, Cellular and Molecular Neuroscience, Biological Psychiatry, Psychiatry and Mental health

الوصف: Accumulating evidence indicates that coronavirus disease 2019 is a major cause of delirium. Given the global dimension of the current pandemic and the fact that delirium is a strong predictor of cognitive decline for critically ill patients, this raises concerns regarding the neurological cost of coronavirus disease 2019. Currently, there is a major knowledge gap related to the covert yet potentially incapacitating higher-order cognitive impairment underpinning coronavirus disease 2019 related delirium. The aim of the current study was to analyse the electrophysiological signatures of language processing in coronavirus disease 2019 patients with delirium by using a specifically designed multidimensional auditory event-related potential battery to probe hierarchical cognitive processes, including self-processing (P300) and semantic/lexical priming (N400). Clinical variables and electrophysiological data were prospectively collected in controls subjects (n = 14) and in critically ill coronavirus disease 2019 patients with (n = 19) and without (n = 22) delirium. The time from intensive care unit admission to first clinical sign of delirium was of 8 (3.5–20) days, and the delirium lasted for 7 (4.5–9.5) days. Overall, we have specifically identified in coronavirus disease 2019 patients with delirium, both a preservation of low-level central auditory processing (N100 and P200) and a coherent ensemble of covert higher-order cognitive dysfunctions encompassing self-related processing (P300) and sematic/lexical language priming (N400) (spatial–temporal clustering, P-cluster ≤ 0.05). We suggest that our results shed new light on the neuropsychological underpinnings of coronavirus disease 2019 related delirium, and may constitute a valuable method for patient’s bedside diagnosis and monitoring in this clinically challenging setting.

الإتاحة: https://doi.org/10.1093/braincomms/fcad073Test
https://academic.oup.com/braincomms/article-pdf/5/2/fcad073/49723718/fcad073.pdfTest

المؤلفون: Oujamaa, Lydia, Delon-Martin, Chantal, Jaroszynski, Chloé, Termenon, Maite, Silva, Stein, Payen, Jean-François, Achard, Sophie

المساهمون: Fondation des Gueules Cassées

المصدر: Brain Communications ; volume 5, issue 6 ; ISSN 2632-1297

مصطلحات موضوعية: Neurology, Cellular and Molecular Neuroscience, Biological Psychiatry, Psychiatry and Mental health

الوصف: Severe traumatic brain injury can lead to transient or even chronic disorder of consciousness. To increase diagnosis and prognosis accuracy of disorder of consciousness, functional neuroimaging is recommended 1 month post-injury. Here, we investigated brain networks remodelling on longitudinal data between 1 and 3 months post severe traumatic brain injury related to change of consciousness. Thirty-four severe traumatic brain-injured patients were included in a cross-sectional and longitudinal clinical study, and their MRI data were compared to those of 20 healthy subjects. Long duration resting-state functional MRI were acquired in minimally conscious and conscious patients at two time points after their brain injury. The first time corresponds to the exit from intensive care unit and the second one to the discharge from post-intensive care rehabilitation ward. Brain networks data were extracted using graph analysis and metrics at each node quantifying local (clustering) and global (degree) connectivity characteristics. Comparison with brain networks of healthy subjects revealed patterns of hyper- and hypo-connectivity that characterize brain networks reorganization through the hub disruption index, a value quantifying the functional disruption in each individual severe traumatic brain injury graph. At discharge from intensive care unit, 24 patients’ graphs (9 minimally conscious and 15 conscious) were fully analysed and demonstrated significant network disruption. Clustering and degree nodal metrics, respectively, related to segregation and integration properties of the network, were relevant to distinguish minimally conscious and conscious groups. At discharge from post-intensive care rehabilitation unit, 15 patients’ graphs (2 minimally conscious, 13 conscious) were fully analysed. The conscious group still presented a significant difference with healthy subjects. Using mixed effects models, we showed that consciousness state, rather than time, explained the hub disruption index differences between ...

الإتاحة: https://doi.org/10.1093/braincomms/fcad319Test
https://academic.oup.com/braincomms/article-pdf/5/6/fcad319/54639175/fcad319.pdfTest

المؤلفون: Gouilly, Dominique, Salabert, Anne-Sophie, Bertrand, Elsa, Goubeaud, Marie, Catala, Hélène, Germain, Johanne, Ainaoui, Nadéra, Rafiq, Marie, Benaiteau, Marie, Carlier, Jasmine, Nogueira, Leonor, Planton, Mélanie, Hitzel, Anne, Méligne, Déborah, Sarton, Benjamine, Silva, Stein, Lemesle, Béatrice, Payoux, Pierre, Thalamas, Claire, Péran, Patrice, Pariente, Jérémie

المصدر: Frontiers in Neurology ; volume 14 ; ISSN 1664-2295

الوصف: The relationship between neuroinflammation and cognition remains uncertain in early Alzheimer’s disease (AD). We performed a cross-sectional study to assess how neuroinflammation is related to cognition using TSPO PET imaging and a multi-domain neuropsychological assessment. A standard uptake value ratio (SUVR) analysis was performed to measure [ 18 F]-DPA-714 binding using the cerebellar cortex or the whole brain as a (pseudo)reference region. Among 29 patients with early AD, the pattern of neuroinflammation was heterogeneous and exhibited no correlation with cognition at voxel-wise, regional or whole-brain level. The distribution of the SUVR values was independent of sex, APOE phenotype, early and late onset of symptoms and the presence of cerebral amyloid angiopathy. However, we were able to demonstrate a complex dissociation as some patients with similar PET pattern had opposed neuropsychological profiles while other patients with opposite PET profiles had similar neuropsychological presentation. Further studies are needed to explore how this heterogeneity impacts disease progression.

الإتاحة: https://doi.org/10.3389/fneur.2023.1189278Test