المؤلفون: Foucher, Yohann, Fournier, Marie-Cécile, Legendre, Christophe, Morelon, Emmanuel, Buron, Fanny, Girerd, Sophie, Ladrière, Marc, Mourad, Georges, Garrigue, Valérie, Glotz, Denis, Lefaucheur, Carmen, Cassuto, Elisabeth, Albano, Laetitia, Giral, Magali, Dantal, Jacques, Hériot, Lyon, Badet, Lionel, Maria Brunet, F, Cahen, Rémi, Daoud, Sameh, Fournie, Coralie, Grégoire, Arnaud, Koenig, Alice, Charlène Lévi, E, Pouteil-Noble, Claire, Rimmelé, Thomas, Thaunat, Olivier, Sylvie Delmas, V, Le Quintrec, Moglie, Pernin, Vincent, Serre, Jean-Emmanuel, Eschwege, Pascal, Luc Frimat, S, Jacques Hubert, M, Laurain, Emmanuelle, Leblanc, Louis, Lecoanet, Pierre, Lemelle, Jean-Louis, Blancho, Gilles, Branchereau, Julien, Cantarovich, Diego, Agnès Chapelet, J, Deltombe, Clément, Figueres, Lucile, Claire Garandeau, M, Gourraud-Vercel, Caroline, Hourmant, Maryvonne, Karam, Georges, Kerleau, Clarisse, Meurette, Aurélie, Ville, Simon, Kandell, Christine, Moreau, Anne, Renaudin, Karine, Cesbron, Anne, Delbos, Florent, Walencik, Alexandre, Devis, Anne, Laeticia Albano, E, Amrouche, Lucile, Anglicheau, Dany, Aubert, Olivier, Lynda Bererhi, C, Loupy, Alexandre, Martinez, Frank, Sberro-Soussan, Rébecca, Scemla, Anne, Tinel, Claire, Zuber, Julien

المساهمون: MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Service de néphrologie pédiatrique CHU Necker, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Edouard Herriot CHU - HCL, Hospices Civils de Lyon (HCL), Service de Transplantation Rénale CHU Brabois, Centre Hospitalier Universitaire de Nancy (CHU Nancy), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Hopital Saint-Louis AP-HP (AP-HP), Hôpital Pasteur Nice (CHU), LabEx TRANSPLANTEX CHU de Nantes, Team 3 : Integrative transplantation, HLA, Immunology and genomics of kidney injury (Team 3 - U1064 Inserm - CR2TI), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE)

المصدر: ISSN: 0931-0509.

مصطلحات موضوعية: Cohort, Kidney transplantation, Machine perfusion, Marginal grafts, Mid-term outcomes, MESH: Aged, MESH: Cohort Studies, MESH: Cryopreservation, MESH: Delayed Graft Function, MESH: Donor Selection, MESH: Female, MESH: Graft Survival, MESH: Humans, MESH: Hypothermia, Induced, MESH: Kidney Transplantation, MESH: Male, MESH: Middle Aged, MESH: Perfusion, MESH: Tissue Donors, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology

الوصف: International audience ; Background Most studies comparing the efficacy of hypothermic machine perfusion (HMP) versus static cold storage (SCS) are based on short-term outcomes. We aimed to better evaluate the mid-term impact of HMP in patients receiving expanded criteria donor (ECD) kidneys. Methods The analyses were based on the French Données Informatisées et VAlidées en Transplantation (DIVAT) observational cohort. Patients aged ≥45 years transplanted for the first or second times from an ECD donor since 2010 were studied. Our study reported the graft and/or patient survivals and the incidence of acute rejection episode. The Cox models and the Kaplan–Meier estimators, weighted on the propensity score, were used to study the times-to-events. Results Among the 2019 included patients, 1073 were in the SCS group versus 946 in the HMP group. The mean life expectancy with functioning graft was 5.7 years [95% confidence interval (CI) 5.4–6.1] for the HMP cohort followed-up for 8 years post-transplantation versus 6.0 years (95% CI 5.7–6.2) for the SCS group. These mid-term results were comparable in the patients receiving grafts from donors aged ≥70 years and in the transplantations with cold ischaemia time ≥18 h. Conclusions Our study challenges the utility of using HMP to improve mid-term patient and graft survival. Nevertheless, the improvement of the short-term outcomes is indisputable. It is necessary to continue technological innovations to obtain long-term results.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32516809; hal-03603017; https://hal.umontpellier.fr/hal-03603017Test; PUBMED: 32516809

الإتاحة: https://doi.org/10.1093/ndt/gfz175Test
https://hal.umontpellier.fr/hal-03603017Test

المؤلفون: Foucher, Yohann, Fournier, Marie-Cécile, Legendre, Christophe, Morelon, Emmanuel, Buron, Fanny, Girerd, Sophie, Ladrière, Marc, Mourad, Georges, Garrigue, Valérie, Glotz, Denis, Lefaucheur, Carmen, Cassuto, Elisabeth, Albano, Laetitia, Giral, Magali, Dantal, Jacques, Hériot, Lyon, Badet, Lionel, Maria Brunet, F, Cahen, Rémi, Daoud, Sameh, Fournie, Coralie, Grégoire, Arnaud, Koenig, Alice, Charlène Lévi, E, Pouteil-Noble, Claire, Rimmelé, Thomas, Thaunat, Olivier, Sylvie Delmas, V, Le Quintrec, Moglie, Pernin, Vincent, Serre, Jean-Emmanuel, Eschwege, Pascal, Luc Frimat, S, Jacques Hubert, M, Laurain, Emmanuelle, Leblanc, Louis, Lecoanet, Pierre, Lemelle, Jean-Louis, Blancho, Gilles, Branchereau, Julien, Cantarovich, Diego, Agnès Chapelet, J, Deltombe, Clément, Figueres, Lucile, Claire Garandeau, M, Gourraud-Vercel, Caroline, Hourmant, Maryvonne, Karam, Georges, Kerleau, Clarisse, Meurette, Aurélie, Ville, Simon, Kandell, Christine, Moreau, Anne, Renaudin, Karine, Cesbron, Anne, Delbos, Florent, Walencik, Alexandre, Devis, Anne, Laeticia Albano, E, Amrouche, Lucile, Anglicheau, Dany, Aubert, Olivier, Lynda Bererhi, C, Loupy, Alexandre, Martinez, Frank, Sberro-Soussan, Rébecca, Scemla, Anne, Tinel, Claire, Zuber, Julien

المساهمون: MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Service de néphrologie pédiatrique CHU Necker, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Edouard Herriot CHU - HCL, Hospices Civils de Lyon (HCL), Service de Transplantation Rénale CHU Brabois, Centre Hospitalier Universitaire de Nancy (CHU Nancy), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Hopital Saint-Louis AP-HP (AP-HP), Hôpital Pasteur Nice (CHU), LabEx TRANSPLANTEX CHU de Nantes, Team 3 : Integrative transplantation, HLA, Immunology and genomics of kidney injury (Team 3 - U1064 Inserm - CR2TI), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE)

المصدر: ISSN: 0931-0509.

مصطلحات موضوعية: Cohort, Kidney transplantation, Machine perfusion, Marginal grafts, Mid-term outcomes, MESH: Aged, MESH: Cohort Studies, MESH: Cryopreservation, MESH: Delayed Graft Function, MESH: Donor Selection, MESH: Female, MESH: Graft Survival, MESH: Humans, MESH: Hypothermia, Induced, MESH: Kidney Transplantation, MESH: Male, MESH: Middle Aged, MESH: Perfusion, MESH: Tissue Donors, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology

الوصف: International audience ; Background Most studies comparing the efficacy of hypothermic machine perfusion (HMP) versus static cold storage (SCS) are based on short-term outcomes. We aimed to better evaluate the mid-term impact of HMP in patients receiving expanded criteria donor (ECD) kidneys. Methods The analyses were based on the French Données Informatisées et VAlidées en Transplantation (DIVAT) observational cohort. Patients aged ≥45 years transplanted for the first or second times from an ECD donor since 2010 were studied. Our study reported the graft and/or patient survivals and the incidence of acute rejection episode. The Cox models and the Kaplan–Meier estimators, weighted on the propensity score, were used to study the times-to-events. Results Among the 2019 included patients, 1073 were in the SCS group versus 946 in the HMP group. The mean life expectancy with functioning graft was 5.7 years [95% confidence interval (CI) 5.4–6.1] for the HMP cohort followed-up for 8 years post-transplantation versus 6.0 years (95% CI 5.7–6.2) for the SCS group. These mid-term results were comparable in the patients receiving grafts from donors aged ≥70 years and in the transplantations with cold ischaemia time ≥18 h. Conclusions Our study challenges the utility of using HMP to improve mid-term patient and graft survival. Nevertheless, the improvement of the short-term outcomes is indisputable. It is necessary to continue technological innovations to obtain long-term results.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32516809; hal-03603017; https://hal.umontpellier.fr/hal-03603017Test; PUBMED: 32516809

الإتاحة: https://doi.org/10.1093/ndt/gfz175Test
https://hal.umontpellier.fr/hal-03603017Test

المؤلفون: Foucher, Yohann, Fournier, Marie-Cécile, Legendre, Christophe, Morelon, Emmanuel, Buron, Fanny, Girerd, Sophie, Ladrière, Marc, Mourad, Georges, Garrigue, Valérie, Glotz, Denis, Lefaucheur, Carmen, Cassuto, Elisabeth, Albano, Laetitia, Giral, Magali, Dantal, Jacques, Hériot, Lyon, Badet, Lionel, Maria Brunet, F, Cahen, Rémi, Daoud, Sameh, Fournie, Coralie, Grégoire, Arnaud, Koenig, Alice, Charlène Lévi, E, Pouteil-Noble, Claire, Rimmelé, Thomas, Thaunat, Olivier, Sylvie Delmas, V, Le Quintrec, Moglie, Pernin, Vincent, Serre, Jean-Emmanuel, Eschwege, Pascal, Luc Frimat, S, Jacques Hubert, M, Laurain, Emmanuelle, Leblanc, Louis, Lecoanet, Pierre, Lemelle, Jean-Louis, Blancho, Gilles, Branchereau, Julien, Cantarovich, Diego, Agnès Chapelet, J, Deltombe, Clément, Figueres, Lucile, Claire Garandeau, M, Gourraud-Vercel, Caroline, Hourmant, Maryvonne, Karam, Georges, Kerleau, Clarisse, Meurette, Aurélie, Ville, Simon, Kandell, Christine, Moreau, Anne, Renaudin, Karine, Cesbron, Anne, Delbos, Florent, Walencik, Alexandre, Devis, Anne, Laeticia Albano, E, Amrouche, Lucile, Anglicheau, Dany, Aubert, Olivier, Lynda Bererhi, C, Loupy, Alexandre, Martinez, Frank, Sberro-Soussan, Rébecca, Scemla, Anne, Tinel, Claire, Zuber, Julien

المساهمون: MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Service de néphrologie pédiatrique CHU Necker, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Edouard Herriot CHU - HCL, Hospices Civils de Lyon (HCL), Service de Transplantation Rénale CHU Brabois, Centre Hospitalier Universitaire de Nancy (CHU Nancy), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Hopital Saint-Louis AP-HP (AP-HP), Hôpital Pasteur Nice (CHU), LabEx TRANSPLANTEX CHU de Nantes, Team 3 : Integrative transplantation, HLA, Immunology and genomics of kidney injury (Team 3 - U1064 Inserm - CR2TI), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE)

المصدر: ISSN: 0931-0509.

مصطلحات موضوعية: Cohort, Kidney transplantation, Machine perfusion, Marginal grafts, Mid-term outcomes, MESH: Aged, MESH: Cohort Studies, MESH: Cryopreservation, MESH: Delayed Graft Function, MESH: Donor Selection, MESH: Female, MESH: Graft Survival, MESH: Humans, MESH: Hypothermia, Induced, MESH: Kidney Transplantation, MESH: Male, MESH: Middle Aged, MESH: Perfusion, MESH: Tissue Donors, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology

الوصف: International audience ; Background Most studies comparing the efficacy of hypothermic machine perfusion (HMP) versus static cold storage (SCS) are based on short-term outcomes. We aimed to better evaluate the mid-term impact of HMP in patients receiving expanded criteria donor (ECD) kidneys. Methods The analyses were based on the French Données Informatisées et VAlidées en Transplantation (DIVAT) observational cohort. Patients aged ≥45 years transplanted for the first or second times from an ECD donor since 2010 were studied. Our study reported the graft and/or patient survivals and the incidence of acute rejection episode. The Cox models and the Kaplan–Meier estimators, weighted on the propensity score, were used to study the times-to-events. Results Among the 2019 included patients, 1073 were in the SCS group versus 946 in the HMP group. The mean life expectancy with functioning graft was 5.7 years [95% confidence interval (CI) 5.4–6.1] for the HMP cohort followed-up for 8 years post-transplantation versus 6.0 years (95% CI 5.7–6.2) for the SCS group. These mid-term results were comparable in the patients receiving grafts from donors aged ≥70 years and in the transplantations with cold ischaemia time ≥18 h. Conclusions Our study challenges the utility of using HMP to improve mid-term patient and graft survival. Nevertheless, the improvement of the short-term outcomes is indisputable. It is necessary to continue technological innovations to obtain long-term results.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32516809; hal-03603017; https://hal.umontpellier.fr/hal-03603017Test; PUBMED: 32516809

الإتاحة: https://doi.org/10.1093/ndt/gfz175Test
https://hal.umontpellier.fr/hal-03603017Test

المؤلفون: Foucher, Yohann, Fournier, Marie-Cécile, Legendre, Christophe, Morelon, Emmanuel, Buron, Fanny, Girerd, Sophie, Ladrière, Marc, Mourad, Georges, Garrigue, Valérie, Glotz, Denis, Lefaucheur, Carmen, Cassuto, Elisabeth, Albano, Laetitia, Giral, Magali, Dantal, Jacques, Hériot, Lyon, Badet, Lionel, Maria Brunet, F, Cahen, Rémi, Daoud, Sameh, Fournie, Coralie, Grégoire, Arnaud, Koenig, Alice, Charlène Lévi, E, Pouteil-Noble, Claire, Rimmelé, Thomas, Thaunat, Olivier, Sylvie Delmas, V, Le Quintrec, Moglie, Pernin, Vincent, Serre, Jean-Emmanuel, Eschwege, Pascal, Luc Frimat, S, Jacques Hubert, M, Laurain, Emmanuelle, Leblanc, Louis, Lecoanet, Pierre, Lemelle, Jean-Louis, Blancho, Gilles, Branchereau, Julien, Cantarovich, Diego, Agnès Chapelet, J, Deltombe, Clément, Figueres, Lucile, Claire Garandeau, M, Gourraud-Vercel, Caroline, Hourmant, Maryvonne, Karam, Georges, Kerleau, Clarisse, Meurette, Aurélie, Ville, Simon, Kandell, Christine, Moreau, Anne, Renaudin, Karine, Cesbron, Anne, Delbos, Florent, Walencik, Alexandre, Devis, Anne, Laeticia Albano, E, Amrouche, Lucile, Anglicheau, Dany, Aubert, Olivier, Lynda Bererhi, C, Loupy, Alexandre, Martinez, Frank, Sberro-Soussan, Rébecca, Scemla, Anne, Tinel, Claire, Zuber, Julien

المساهمون: MethodS in Patients-centered outcomes and HEalth ResEarch (SPHERE), Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN), Centre hospitalier universitaire de Nantes (CHU Nantes), Service de néphrologie pédiatrique CHU Necker, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Edouard Herriot CHU - HCL, Hospices Civils de Lyon (HCL), Service de Transplantation Rénale CHU Brabois, Centre Hospitalier Universitaire de Nancy (CHU Nancy), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Hopital Saint-Louis AP-HP (AP-HP), Hôpital Pasteur Nice (CHU), LabEx TRANSPLANTEX CHU de Nantes, Immunotherapy in Transplantation And Autoimmunity (Team 3 - U1064 Inserm - CRTI), Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)

المصدر: ISSN: 0931-0509.

مصطلحات موضوعية: Cohort, Kidney transplantation, Machine perfusion, Marginal grafts, Mid-term outcomes, MESH: Aged, MESH: Cohort Studies, MESH: Male, MESH: Middle Aged, MESH: Perfusion, MESH: Tissue Donors, MESH: Cryopreservation, MESH: Delayed Graft Function, MESH: Donor Selection, MESH: Female, MESH: Graft Survival, MESH: Humans, MESH: Hypothermia, Induced, MESH: Kidney Transplantation, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology

الوصف: International audience ; Background Most studies comparing the efficacy of hypothermic machine perfusion (HMP) versus static cold storage (SCS) are based on short-term outcomes. We aimed to better evaluate the mid-term impact of HMP in patients receiving expanded criteria donor (ECD) kidneys. Methods The analyses were based on the French Données Informatisées et VAlidées en Transplantation (DIVAT) observational cohort. Patients aged ≥45 years transplanted for the first or second times from an ECD donor since 2010 were studied. Our study reported the graft and/or patient survivals and the incidence of acute rejection episode. The Cox models and the Kaplan–Meier estimators, weighted on the propensity score, were used to study the times-to-events. Results Among the 2019 included patients, 1073 were in the SCS group versus 946 in the HMP group. The mean life expectancy with functioning graft was 5.7 years [95% confidence interval (CI) 5.4–6.1] for the HMP cohort followed-up for 8 years post-transplantation versus 6.0 years (95% CI 5.7–6.2) for the SCS group. These mid-term results were comparable in the patients receiving grafts from donors aged ≥70 years and in the transplantations with cold ischaemia time ≥18 h. Conclusions Our study challenges the utility of using HMP to improve mid-term patient and graft survival. Nevertheless, the improvement of the short-term outcomes is indisputable. It is necessary to continue technological innovations to obtain long-term results.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32516809; hal-03603017; https://hal.umontpellier.fr/hal-03603017Test; PUBMED: 32516809

الإتاحة: https://doi.org/10.1093/ndt/gfz175Test
https://hal.umontpellier.fr/hal-03603017Test