المؤلفون: Gilbert Ndziessi, Julien Cohen, Charles Kouanfack, Fabienne Marcellin, Maria Patrizia Carrieri, Gabrièle Laborde-Balen, Camélia Protopopescu, Avelin Fobang Aghokeng, Jean-Paul Moatti, Bruno Spire, Eric Delaporte, Christian Laurent, Sylvie Boyer, M. Biwolé-Sida, C. Kouanfack, S. Koulla-Shiro, A. Bourgeois, E. Delaporte, C. Laurent, M. Peeters, G. Laborde-Balen, M. Dontsop, S. Kazé, J-M. Mben, A. Aghokeng, M.G. Edoul, E. Mpoudi-Ngolé, M. Tongo, S. Boyer, M.P. Carrieri, F. Marcellin, J-P. Moatti, B. Spire, C. Abé, S-C. Abega, C-R. Bonono, H. Mimcheu, S. Ngo Yebga, C. Paul Bile, S. Abada, T. Abanda, J. Baga, P. Bilobi Fouda, P. Etong Mve, G. Fetse Tama, H. Kemo, A. Ongodo, V. Tadewa, HD. Voundi, A. Ambani, M. Atangana, J-C. Biaback, M. Kennedy, H. Kibedou, F. Kounga, M. Maguip Abanda, E. Mamang, A. Mikone, S. Tang, E. Tchuangue, S. Tchuenko, D. Yakan, J. Assandje, S. Ebana, D. Ebo’o, D. Etoundi, G. Ngama, P. Mbarga Ango, J. Mbezele, G. Mbong, C. Moung, N. Ekotto, G. Nguemba Balla, G. Ottou, M. Tigougmo, R. Beyala, B. Ebene, C. Effemba, F. Eyebe, M-M. Hadjaratou, T. Mbarga, M. Metou, M. Ndam, B. Ngoa, EB. Ngock, N. Obam, A. M. Abomo, G. Angoula, E. Ekassi, Essama, J.J. Lentchou, I. Mvilongo, J. Ngapou, F. Ntokombo, V. Ondoua, R. Palawo, S. Sebe, E. Sinou, D. Wankam, I. Zobo, B. Akono, A. L. Ambani, L. Bilock, R. Bilo’o, J. Boombhi, F.X. Fouda, M. Guitonga, R. Mad’aa, D.R. Metou’ou, S. Mgbih, A. Noah, M. Tadena, Ntcham, G. Ambassa Elime, A.A. Bonongnaba, E. Foaleng, R.M. Heles, R. Messina, O. Nana Ndankou, S.A. Ngono, D. Ngono Menounga, S.S. Sil, L. Tchouamou, B. Zambou, R. Abomo, J. Ambomo, C. Beyomo, P. Eloundou, C. Ewole, J. Fokom, M. Mvoto, M. Ngadena, R. Nyolo, C. Onana, A. Oyie, P. Antyimi, S. Bella Mbatonga, M. Bikomo, Y. Molo Bodo, S. Ndi Ntang, P. Ndoudoumou, L. Ndzomo, S.O. Ngolo, M. Nkengue, Nkoa, Y. Tchinda

المصدر: PLoS ONE, Vol 8, Iss 7 (2013)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC3738650Test; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/46b5bc0cc49749b394fef67ee65de858Test

المؤلفون: M, Meresse, L, March, C, Kouanfack, R-C, Bonono, S, Boyer, G, Laborde-Balen, A, Aghokeng, M, Suzan-Monti, E, Delaporte, B, Spire, M-P, Carrieri, C, Laurent, Y, Tchinda

المصدر: HIV medicine. 15(8)

مصطلحات موضوعية: Adult, Male, Time Factors, Genotype, HIV Infections, Viral Load, Hospitals, District, Medication Adherence, Cohort Studies, Interviews as Topic, Anti-Retroviral Agents, Antiretroviral Therapy, Highly Active, Drug Resistance, Viral, HIV-1, Humans, Female, Cameroon

الوصف: The emergence of HIV drug resistance is a crucial issue in Africa, where second-line antiretroviral therapy (ART) is limited, expensive and complex. We assessed the association between adherence patterns and resistance emergence over time, using an adherence measure that distinguishes low adherence from treatment interruptions, in rural Cameroon.We performed a cohort study among patients receiving nonnucleoside reverse transcriptase inhibitor (NNRTI)-based ART in nine district hospitals, using data from the Stratall trial (2006-2010). Genotypic mutations associated with antiretroviral drug resistance were assessed when 6-monthly HIV viral loads were 5000 HIV-1 RNA copies/mL. ART adherence data were collected using face-to-face questionnaires. Combined indicators of early (1-3 months) and late (6 months to t - 1; t is the time point when the resistance had been detected) adherence were constructed. Multivariate logistic regression and Cox models were used to assess the association between adherence patterns and early (at 6 months) and late (after 6 months) resistance emergence, respectively.Among 456 participants (71% women; median age 37 years), 45 developed HIV drug resistance (18 early and 27 late). Early low adherence ( 80%) and treatment interruptions ( 2 days) were associated with early resistance [adjusted odds ratio (95% confidence interval) 8.51 (1.30-55.61) and 5.25 (1.45-18.95), respectively]. Early treatment interruptions were also associated with late resistance [adjusted hazard ratio (95% confidence interval) 3.72 (1.27-10.92)].The emergence of HIV drug resistance on first-line NNRTI-based regimens was associated with different patterns of adherence over time. Ensuring optimal early adherence through specific interventions, adequate management of drug stocks, and viral load monitoring is a clinical and public health priority in Africa.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::9f65b36dcc21f2dc0f0c39b221e2e455Test
https://pubmed.ncbi.nlm.nih.gov/24589279Test