دورية أكاديمية
Concurrent BMP Signaling Maintenance and TGF-β Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear
| العنوان: | Concurrent BMP Signaling Maintenance and TGF-β Signaling Inhibition Is a Hallmark of Natural Resistance to Muscle Atrophy in the Hibernating Bear |
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| المؤلفون: | Cussonneau, Laura, Boyer, Christian, Brun, Charlotte, Deval, Christiane, Loizon, Emmanuelle, Meugnier, Emmanuelle, Gueret, Elise, Dubois, Emeric, Taillandier, Daniel, Polge, Cécile, Béchet, Daniel, Gauquelin-Koch, Guillemette, Evans, Alina, Arnemo, Jon, Swenson, Jon, Blanc, Stéphane, Simon, Chantal, Lefai, Etienne, Bertile, Fabrice, Combaret, Lydie |
| المساهمون: | Unité de Nutrition Humaine (UNH), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA), Université Côte d'Azur - Faculté de Médecine (UCA Faculté Médecine), Université Côte d'Azur (UniCA), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Génomique Fonctionnelle - Montpellier GenomiX (IGF MGX), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-BioCampus (BCM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National d’Études Spatiales Paris (CNES), Inland Norway University of Applied Sciences - Høgskolen i Innlandet, Swedish University of Agricultural Sciences = Sveriges lantbruksuniversitet (SLU), Norwegian University of Life Sciences (NMBU) |
| المصدر: | ISSN: 2073-4409 ; Cells ; https://hal.inrae.fr/hal-03314541Test ; Cells, 2021, 10 (8), pp.1873. ⟨10.3390/cells10081873⟩. |
| بيانات النشر: | HAL CCSD MDPI |
| سنة النشر: | 2021 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | muscle atrophy, physical inactivity, RNA sequencing, TGF-β/BMP signaling, brown bear hibernation, mouse unloading, [SDV]Life Sciences [q-bio], [SDV.BC]Life Sciences [q-bio]/Cellular Biology |
| الوصف: | International audience ; Muscle atrophy arises from a multiplicity of physio-pathological situations and has very detrimental consequences for the whole body. Although knowledge of muscle atrophy mechanisms keeps growing, there is still no proven treatment to date. This study aimed at identifying new drivers for muscle atrophy resistance. We selected an innovative approach that compares muscle transcriptome between an original model of natural resistance to muscle atrophy, the hibernating brown bear, and a classical model of induced atrophy, the unloaded mouse. Using RNA sequencing, we identified 4415 differentially expressed genes, including 1746 up- and 2369 down-regulated genes, in bear muscles between the active versus hibernating period. We focused on the Transforming Growth Factor (TGF)-β and the Bone Morphogenetic Protein (BMP) pathways, respectively, involved in muscle mass loss and maintenance. TGF-β- and BMP-related genes were overall down- and up-regulated in the non-atrophied muscles of the hibernating bear, respectively, and the opposite occurred for the atrophied muscles of the unloaded mouse. This was further substantiated at the protein level. Our data suggest TGF-β/BMP balance is crucial for muscle mass maintenance during long-term physical inactivity in the hibernating bear. Thus, concurrent activation of the BMP pathway may potentiate TGF-β inhibiting therapies already targeted to prevent muscle atrophy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34440643; hal-03314541; https://hal.inrae.fr/hal-03314541Test; https://hal.inrae.fr/hal-03314541/documentTest; https://hal.inrae.fr/hal-03314541/file/cells-10-01873-v2%20%281%29.pdfTest; PUBMED: 34440643; PUBMEDCENTRAL: PMC8393865; WOS: 000688955200001 |
| DOI: | 10.3390/cells10081873 |
| الإتاحة: | https://doi.org/10.3390/cells10081873Test https://hal.inrae.fr/hal-03314541Test https://hal.inrae.fr/hal-03314541/documentTest https://hal.inrae.fr/hal-03314541/file/cells-10-01873-v2%20%281%29.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.298E5C23 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cells10081873 |
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