نتائج البحث - "NASH non-alcoholic steatohepatitis"

1

LIX1-like protein promotes liver cancer progression via miR-21-3p-mediated inhibition of fructose-1,6-bisphosphatase

المؤلفون: Jie Li, Xiaoyun Zhu, Jie Zou, Hao Zhang, Dejuan Xiang, Ling-Yi Kong, Zhigui Su, Yanqiu Zhang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1578-1591 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Hepatocellular carcinoma, NASH, non-alcoholic steatohepatitis, Proliferation, Fructose 1,6-bisphosphatase, RM1-950, Carbohydrate metabolism, LIX1L, Limb and CNS expressed 1 like, Metastasis, 03 medical and health sciences, 0302 clinical medicine, FBP1, CCl4, carbon tetrachloride, miRNA, microRNA, medicine, shRNA, short-hairpin RNA, General Pharmacology, Toxicology and Pharmaceutics, 030304 developmental biology, Glucose metabolism, 0303 health sciences, Gene knockdown, ECAR, extracellular acidification rate, biology, business.industry, Gluconeogenesis, Cell migration, medicine.disease, Seq, sequencing, LIX1L, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Original Article, miR-21-3p, Therapeutics. Pharmacology, HCC, hepatocellular carcinoma, Liver cancer, business, EMT, epithelial–mesenchymal transition, FBP1, fructose-1,6-bisphosphatase 1, DEN, diethylnitrosamine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c970bf879a240521753514a3be8c82cTest
https://doi.org/10.1016/j.apsb.2021.02.005Test

2

Clinical trial of autologous adipose tissue-derived regenerative (stem) cells therapy for exploration of its safety and efficacy

المصدر: Regenerative Therapy
Regenerative Therapy, Vol 18, Iss, Pp 97-101 (2021)

مصطلحات موضوعية: 0301 basic medicine, Medicine (General), medicine.medical_specialty, Cirrhosis, MSCs, mesenchymal stem cells, Adipose tissue dissociation device, NASH, non-alcoholic steatohepatitis, Biomedical Engineering, Adipose tissue, Gastroenterology, Biomaterials, Cell therapy, 03 medical and health sciences, R5-920, 0302 clinical medicine, Internal medicine, Fatty liver diseases, medicine, Adipose tissue-derived regenerative (stem) cells, Non-alcoholic steatohepatitis, QH573-671, business.industry, Fatty liver, Conductible, ADRCs, adipose tissue derived regenerative (stem) cells, medicine.disease, Clinical trial, 030104 developmental biology, PMDA, Japan Pharmaceuticals and Medical Devices Agency, Liver cirrhosis, Original Article, NAFLD, nonalcoholic fatty liver disease, Steatohepatitis, Stem cell, Cytology, business, 030217 neurology & neurosurgery, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498cb8601adedc4119b89a161cd23e11Test
http://europepmc.org/articles/PMC8165289Test

3

Incidence, characteristics, and outcome of COVID-19 in patients on liver transplant program: a retrospective study in the north of Iran

المؤلفون: Pirouz Samidoust, Mohammad Taghi Ashoobi, R. Navid Talemi, M.S. Esmaeili Delshad, K. Mojtahedi, Aryan Samidoust, S. Jahangiri

المصدر: New Microbes and New Infections, Vol 44, Iss, Pp 100935-(2021)
New Microbes and New Infections

مصطلحات موضوعية: medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, AST, aspartate aminotransferase, Disease, Infectious and parasitic diseases, RC109-216, Liver transplantation, Iran, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Microbiology, ACE2, angiotensin-converting enzyme-2, Internal medicine, medicine, HDL, High-density lipoprotein, liver transplant recipients, DBIL, direct bilirubin, CTscan, computed tomography scan, CDC, Centers for Disease Control, In patient, TBIL, total bilirubin, NSAIDs, nonsteroidal anti-inflammatory drugs, HBV, Hepatitis B, NASH, Non-alcoholic steatohepatitis, Liver injury, liver transplantation, business.industry, SARS-CoV-2, Incidence (epidemiology), COVID-19, Retrospective cohort study, medicine.disease, PSC, primary sclerosing cholangitis, Infectious Diseases, Original Article, SD, standard deviation, business, TBIL

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990cdcfd9e698bf3a0e2b7d10e9e6b75Test
http://www.sciencedirect.com/science/article/pii/S2052297521000998Test

4

Mesenchymal stem cells cultured under hypoxic conditions had a greater therapeutic effect on mice with liver cirrhosis compared to those cultured under normal oxygen conditions

المؤلفون: Masaru Ishii, Junichi Kikuta, Atsunori Tsuchiya, Masaaki Takamura, Kenji Nakajima, Hara Yukio, Masahiro Ogawa, Suguru Takeuchi, Shunsuke Nojiri, Yuichi Kojima, Junji Yamashita, Shuji Terai, Takayuki Watanabe

المصدر: Regenerative Therapy, Vol 11, Iss, Pp 269-281 (2019)
Regenerative Therapy

مصطلحات موضوعية: 0301 basic medicine, Cirrhosis, ALP, Alkaline phosphatase, Adipose tissue, PGE2, Prostaglandin E2, Pharmacology, medicine.disease_cause, Prostaglandin E synthase, SOD, Superoxide dismutase, Cell therapy, hypoMSCs, MSCs cultured under hypoxic oxygen (5% O2) conditions, 0302 clinical medicine, norMSCs, MSCs cultured under normal oxygen (21% O2) conditions, Fibrosis, CAGE, Cap analysis of gene expression, Prostaglandin E2, LPS, Lipopolysaccharide, lcsh:R5-920, biology, HHSteC, Human Hepatic Stellate Cells, Chemistry, lcsh:Cytology, 8-OHdG, DNA 8-hydroxy-2’-deoxyguanosine, ALB, Albumin, id-BMM, Induced Bone Marrow Derived Macrophage, Original Article, PGE2, lcsh:Medicine (General), medicine.drug, T-Bil, Total bilirubin, Biomedical Engineering, Biomaterials, 03 medical and health sciences, ECM, Extracellular matrix, Hypoxic condition, medicine, lcsh:QH573-671, MDA, Malondialdehyde, LC, Liver cirrhosis, NASH, Non-alcoholic steatohepatitis, miR210, Mesenchymal stem cell, ALT, Alanine aminotransferase, MSCs, Mesenchymal stem cells, medicine.disease, 030104 developmental biology, Liver cirrhosis, biology.protein, Mesenchymal stem cells, PCR, Polymerase chain reaction, CCl4, Carbon tetrachloride, 030217 neurology & neurosurgery, Oxidative stress, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796000c604663d3d982bebac495f5eedTest
http://www.sciencedirect.com/science/article/pii/S2352320419300811Test

5

Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload

المؤلفون: Hans-Peter Hammes, Elena Heidenreich, Peter P. Nawroth, Martina U. Muckenthaler, Sandro Altamura, Thomas Fleming, Andrea Schlotterer, Katja Müdder, Ruiyue Qiu

المصدر: Molecular Metabolism, Vol 51, Iss, Pp 101235-(2021)
Molecular Metabolism

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, DR, diabetic retinopathy, Hepcidin, medicine.disease_cause, Mice, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, MetS, Metabolic Syndrome, Internal medicine, biology, Fpn, Ferroportin, Fatty liver, Liver, DIOS, dysmetabolic iron overload syndrome, CRP, C-reactive protein, Receptors, Leptin, HH, hereditary hemochromatosis, Original Article, IRP, Iron Regulatory Protein, medicine.medical_specialty, Iron Overload, Iron, 030209 endocrinology & metabolism, Mice, Transgenic, IR, Insulin Resistance, SEM, standard error of the mean, 03 medical and health sciences, Insulin resistance, ROS, reactive oxygen species, NASH, Non Alcoholic Steatohepatitis, NAFLD, medicine, Animals, Humans, Molecular Biology, business.industry, NTBI, Non Transferrin Bound Iron, Cell Biology, medicine.disease, RC31-1245, IRS1, Db/db Mouse, Disease Models, Animal, Oxidative Stress, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, biology.protein, NAFLD, Non Alcoholic Fatty Liver Disease, Lipid Peroxidation, Steatosis, Metabolic syndrome, business, Oxidative stress, IRE, Iron Responsive Element, T2DM, Type 2 Diabetes Mellitus

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746ad7abfa625d87337f2502f8e59462Test
http://www.sciencedirect.com/science/article/pii/S2212877821000806Test

6

Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates

المؤلفون: Carrie E. McCurdy, Kenneth N. Maclean, Paul Kievit, Bryan C. Bergman, Rachel C. Janssen, Peter R. Baker, Christopher M. Mulligan, Tyler Dean, Diana L. Takahashi, Travis Nemkov, Kjersti Aagaard, Hua Jiang, Stephanie R. Wesolowski, Angelo D'Alessandro, Jacob E. Friedman

المصدر: Molecular Metabolism, Vol 18, Iss, Pp 25-41 (2018)
Molecular Metabolism

مصطلحات موضوعية: 0301 basic medicine, Steatosis, VIP, variable importance in projection, Hypoxemia, AUC, area under the curve, PC, phosphatidylcholine, 0302 clinical medicine, WSD, Western-style diet, Non-alcoholic Fatty Liver Disease, Pregnancy, Fetal programming, Hyperlipidemia, DAG, diacylglyceride, VLDL, very low-density lipoprotein, Hypoxia, 2. Zero hunger, TG, triglyceride, NEFA, non-esterified fatty acid, NHP, non-human primate, Fatty liver, 3. Good health, Liver, Lipotoxicity, CON, control, OB-WSD, Western-style diet induced obesity group, IV-GTT, intravenous glucose tolerance test, Prenatal Exposure Delayed Effects, Original Article, Female, Diet, Healthy, PLS-DA, partial least squares discriminant analysis, TCA, tricarboxylic acid cycle, NAFLD, non-alcoholic fatty liver disease, lcsh:Internal medicine, medicine.medical_specialty, Offspring, NASH, non-alcoholic steatohepatitis, Citric Acid Cycle, Metabolomic, 030209 endocrinology & metabolism, DNL, de novo lipogenesis, TBARs, thiobarbituric acid reactive substances, OB-DR, diet reversal group, 03 medical and health sciences, Fetus, Internal medicine, medicine, TBARS, Animals, Obesity, AA, amino acid, lcsh:RC31-1245, Molecular Biology, Triglycerides, business.industry, Gluconeogenesis, Maternal Nutritional Physiological Phenomena, Cell Biology, medicine.disease, Oxidative Stress, 030104 developmental biology, Endocrinology, Diet, Western, Macaca, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06dccd8288a52f01636dbe7fd72ba0fTest
https://doi.org/10.1016/j.molmet.2018.09.008Test

7

Development of a non-alcoholic steatohepatitis model with rapid accumulation of fibrosis, and its treatment using mesenchymal stem cells and their small extracellular vesicles

المؤلفون: Takayoshi Suganami, Shuji Terai, Shunsuke Nojiri, Masahiro Ogawa, Tomoaki Yoshida, Atsunori Tsuchiya, Suguru Takeuchi, Takayuki Watanabe, Yoshihiro Ogawa, Masaaki Takamura, Michiko Itoh

المصدر: Regenerative Therapy
Regenerative Therapy, Vol 14, Iss, Pp 252-261 (2020)

مصطلحات موضوعية: 0301 basic medicine, NAFLD, non-alcoholic fatty liver disease, Cirrhosis, MC4R, melanocortin-4 receptor-deficient, Lipopolysaccharide, ALT, alanine transaminase, NASH, non-alcoholic steatohepatitis, Biomedical Engineering, Adipose tissue, MSC, mesenchymal stem cell, Small extracellular vesicles, Pharmacology, hCLS, hepatic crown-like structure, Biomaterials, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, MCD, methionine-choline-deficient diet, Fibrosis, sEV, small extracellular vesicle, medicine, lcsh:QH573-671, Receptor, Non-alcoholic steatohepatitis, lcsh:R5-920, WD, Western diet, biology, business.industry, lcsh:Cytology, ND, normal diet, Mesenchymal stem cell, medicine.disease, 030104 developmental biology, chemistry, Alanine transaminase, biology.protein, Mesenchymal stem cells, Original Article, Steatohepatitis, business, lcsh:Medicine (General), HCC, hepatocellular carcinoma, T-bil, total bilirubin, T-cho, total cholesterol, 030217 neurology & neurosurgery, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c605b87d1574bec9c086c0f3c9517bTest
https://pubmed.ncbi.nlm.nih.gov/32455155Test

8

Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR

المؤلفون: Yanyong Xu, Kavita Jadhav, Yingdong Zhu, Yuan-Yuan Li, Takhar Kasumov, Jiesi Xu, Yang Xu, Luciano Adorini, Yoon Kwang Lee, Yanqiao Zhang, Liya Yin

المصدر: Molecular Metabolism, Vol 9, Iss, Pp 131-140 (2018)
Molecular Metabolism

مصطلحات موضوعية: Male, 0301 basic medicine, Col1α1, collagen type 1 α1, NS, not significant, Receptors, Cytoplasmic and Nuclear, PPARγ, peroxisome proliferation-activated receptor γ, Receptors, G-Protein-Coupled, Mice, IL-1β, interleukin 1β, SHP, small heterodimer partner, α-Sma, alpha smooth muscle actin (α-Sma), HFD, high fat diet, Non-alcoholic Fatty Liver Disease, Tgfβ, transforming growth factor β, Receptor, TG, triglyceride, Bile acid, Chemistry, TGR5, GLP-1, glucagon-like peptide-1, Hep G2 Cells, Peroxisome, G protein-coupled bile acid receptor, 3. Good health, TNFα, tumor necrosis factor α, Pck1, phosphoenoylpyruvate carboxylase 1, TGR5, G protein coupled bile acid receptor (GPBAP), Lipogenesis, BA, bile acid, G6pc, glucose 6-phosphatase, Small heterodimer partner, Original Article, Agonist, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, lcsh:Internal medicine, Timp1, tissue inhibitor of metalloproteinase 1, medicine.drug_class, NASH, non-alcoholic steatohepatitis, Hypercholesterolemia, Diet, High-Fat, Bile Acids and Salts, 03 medical and health sciences, FXR, farnesoid X receptor, Farnesoid X receptor, NAFLD, Internal medicine, medicine, Animals, Humans, Obesity, lcsh:RC31-1245, Molecular Biology, CEBPα, CCAAT/enhancer-binding protein α, DIO, diet-induced obesity, Cell Biology, Atherosclerosis, Mice, Inbred C57BL, BAT, brown adipose tissue, 030104 developmental biology, Endocrinology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6f686d41c1a501b1cae42176973abbTest
http://www.sciencedirect.com/science/article/pii/S2212877817309195Test

9

Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis

المؤلفون: Miguel López, Rubén Nogueiras, Xabier Buqué, Maria J. Gonzalez-Rellan, Daniel Beiroa, Patricia Aspichueta, Uxia Fernandez, Begoña Porteiro, Rosalía Gallego, Carlos Dieguez, Guadalupe Sabio, Marcos F. Fondevila, Johan Fernø, Ana Senra, Alfonso Mora

المساهمون: Ministerio de Economía y Competitividad (España), Xunta de Galicia (España), Heise Vest RHF, Comunidad de Madrid (España), Basque Government (España), Fundación AstraZeneca, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Unión Europea. Comisión Europea, Centro de Investigación Biomedica en Red - CIBER

المصدر: Molecular Metabolism, Vol 8, Iss, Pp 132-143 (2018)
Molecular Metabolism
Repisalud
Instituto de Salud Carlos III (ISCIII)

مصطلحات موضوعية: 0301 basic medicine, pIRE, Inositol-requiring enzyme 1 α, pJNK, phospho c-Jun N-terminal kinase, ACC, acetyl-CoA carboxylase, AST, aspartate aminotransferase, XBP1s, X-box binding protein 1, Abcd1, ATP binding cassette subfamily D member 1, Pharmacology, ER stress, endoplasmic reticulum stress, NFκβ, nuclear factor kappa b, FA, free fatty acid, Mice, Liver disease, UPR, unfolded protein response, 0302 clinical medicine, HFD, high fat diet, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, DG, diacylglycerol, Topoisomerase II Inhibitors, IL6, initerleukin 6, Beta oxidation, Acadm, acyl-CoA deshydrogenase, medium chain, GFP, green fluorescent protein, IL10, interleukin 10, Acox, acyl-CoA oxidase 1, TG, triglyceride, Ad, adenovirus, Hep G2 Cells, Acadl, acyl-CoA deshydrogenase, long-chain, i.p., intraperitoneal, FAS, fatty acid synthase, 3. Good health, Liver, Pparα, peroxisome proliferator activated receptor alpha, JNK, c-Jun N-terminal kinase, Lipogenesis, DOX, Doxorubicin, DN, dominant negative, Original Article, ApoB, apolipoprotein b, Quer, quercetin, NAFLD, non-alcoholic fatty liver disease, lcsh:Internal medicine, ASM, acid-soluble metabolites, NASH, non-alcoholic steatohepatitis, TNFα, tumor necrosis factor alpha, GAPDH, glyceraldehyde-3-phosphate deshydrogenase, AUC, area under curve, Diet, High-Fat, Cell Line, SPF, specific pathogen free room, 03 medical and health sciences, GTT, glucose test tolerance, ALT, alanine aminotransferase, AAV8, adeno-associated virus serotype 8, medicine, Animals, Humans, Obesity, EC, sterified cholesterol, lcsh:RC31-1245, Molecular Biology, MCD, methionine-choline deficient diet, CHOP, C/EBP-homologous protein, Inflammation, business.industry, OA, oleic acid, Lipid metabolism, DIO, diet-induced obesity, Cell Biology, Lipid Metabolism, medicine.disease, CDHFD, choline-deficient high fat diet, Mice, Inbred C57BL, 030104 developmental biology, Doxorubicin, pACC, phospho acetyl-CoA carboxylase, Hepatic stellate cell, BSA, bovine serum albumin, Tumor Suppressor Protein p53, Steatohepatitis, Steatosis, business, Fatp2, solute carrier family 27 (fatty acid transporter) member 2, IL1β, interleukin 1beta, 030217 neurology & neurosurgery, ITT, insulin test tolerance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7642e1971aebb46c881386960e7affTest
http://www.sciencedirect.com/science/article/pii/S2212877817310116Test

10

The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

المؤلفون: Adam J. Rauckhorst, Xiaorong Fu, Katherine N. Gibson-Corley, Alvin D. Pewa, Ryan D. Sheldon, Eric B. Taylor, James E. Cox, Charlotte R. Feddersen, Shawn C. Burgess, Adam J. Dupuy, Lawrence R. Gray

المصدر: Molecular Metabolism, Vol 6, Iss 11, Pp 1468-1479 (2017)
Molecular Metabolism

مصطلحات موضوعية: Blood Glucose, 0301 basic medicine, Mitochondria, Liver, Mitochondrion, Mitochondrial Membrane Transport Proteins, Mice, 0302 clinical medicine, HFD, high fat diet, Fibrosis, immune system diseases, Pyruvic Acid, digestive, oral, and skin physiology, Diabetes, Mitochondria, HOMA-IR, homeostatic model assessment of insulin resistance, medicine.anatomical_structure, Liver, Mitochondrial matrix, 030220 oncology & carcinogenesis, Hepatocyte, Original Article, MPC, mitochondrial pyruvate carrier, TCA, tricarboxylic acid cycle, Monocarboxylic Acid Transporters, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, lcsh:Internal medicine, NASH, non-alcoholic steatohepatitis, Anion Transport Proteins, Citric Acid Cycle, T2D, type 2 diabetes, Biology, Diet, High-Fat, Mitochondrial pyruvate carrier (MPC), 03 medical and health sciences, Internal medicine, medicine, Animals, Obesity, lcsh:RC31-1245, Molecular Biology, ITT, insulin tolerance test, Inflammation, NCD, normal chow diet, Gluconeogenesis, Membrane Transport Proteins, nutritional and metabolic diseases, Cell Biology, Metabolism, medicine.disease, Citric acid cycle, Disease Models, Animal, Cytosol, Glucose, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Hyperglycemia, Hepatocytes, Insulin Resistance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80260421dd9726225c6f9a3cac3cf9faTest
http://www.sciencedirect.com/science/article/pii/S2212877817306828Test

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