المؤلفون: Carrie E. McCurdy, Kenneth N. Maclean, Paul Kievit, Bryan C. Bergman, Rachel C. Janssen, Peter R. Baker, Christopher M. Mulligan, Tyler Dean, Diana L. Takahashi, Travis Nemkov, Kjersti Aagaard, Hua Jiang, Stephanie R. Wesolowski, Angelo D'Alessandro, Jacob E. Friedman

المصدر: Molecular Metabolism, Vol 18, Iss, Pp 25-41 (2018)
Molecular Metabolism

مصطلحات موضوعية: 0301 basic medicine, Steatosis, VIP, variable importance in projection, Hypoxemia, AUC, area under the curve, PC, phosphatidylcholine, 0302 clinical medicine, WSD, Western-style diet, Non-alcoholic Fatty Liver Disease, Pregnancy, Fetal programming, Hyperlipidemia, DAG, diacylglyceride, VLDL, very low-density lipoprotein, Hypoxia, 2. Zero hunger, TG, triglyceride, NEFA, non-esterified fatty acid, NHP, non-human primate, Fatty liver, 3. Good health, Liver, Lipotoxicity, CON, control, OB-WSD, Western-style diet induced obesity group, IV-GTT, intravenous glucose tolerance test, Prenatal Exposure Delayed Effects, Original Article, Female, Diet, Healthy, PLS-DA, partial least squares discriminant analysis, TCA, tricarboxylic acid cycle, NAFLD, non-alcoholic fatty liver disease, lcsh:Internal medicine, medicine.medical_specialty, Offspring, NASH, non-alcoholic steatohepatitis, Citric Acid Cycle, Metabolomic, 030209 endocrinology & metabolism, DNL, de novo lipogenesis, TBARs, thiobarbituric acid reactive substances, OB-DR, diet reversal group, 03 medical and health sciences, Fetus, Internal medicine, medicine, TBARS, Animals, Obesity, AA, amino acid, lcsh:RC31-1245, Molecular Biology, Triglycerides, business.industry, Gluconeogenesis, Maternal Nutritional Physiological Phenomena, Cell Biology, medicine.disease, Oxidative Stress, 030104 developmental biology, Endocrinology, Diet, Western, Macaca, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06dccd8288a52f01636dbe7fd72ba0fTest
https://doi.org/10.1016/j.molmet.2018.09.008Test

المؤلفون: Yanyong Xu, Kavita Jadhav, Yingdong Zhu, Yuan-Yuan Li, Takhar Kasumov, Jiesi Xu, Yang Xu, Luciano Adorini, Yoon Kwang Lee, Yanqiao Zhang, Liya Yin

المصدر: Molecular Metabolism, Vol 9, Iss, Pp 131-140 (2018)
Molecular Metabolism

مصطلحات موضوعية: Male, 0301 basic medicine, Col1α1, collagen type 1 α1, NS, not significant, Receptors, Cytoplasmic and Nuclear, PPARγ, peroxisome proliferation-activated receptor γ, Receptors, G-Protein-Coupled, Mice, IL-1β, interleukin 1β, SHP, small heterodimer partner, α-Sma, alpha smooth muscle actin (α-Sma), HFD, high fat diet, Non-alcoholic Fatty Liver Disease, Tgfβ, transforming growth factor β, Receptor, TG, triglyceride, Bile acid, Chemistry, TGR5, GLP-1, glucagon-like peptide-1, Hep G2 Cells, Peroxisome, G protein-coupled bile acid receptor, 3. Good health, TNFα, tumor necrosis factor α, Pck1, phosphoenoylpyruvate carboxylase 1, TGR5, G protein coupled bile acid receptor (GPBAP), Lipogenesis, BA, bile acid, G6pc, glucose 6-phosphatase, Small heterodimer partner, Original Article, Agonist, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, lcsh:Internal medicine, Timp1, tissue inhibitor of metalloproteinase 1, medicine.drug_class, NASH, non-alcoholic steatohepatitis, Hypercholesterolemia, Diet, High-Fat, Bile Acids and Salts, 03 medical and health sciences, FXR, farnesoid X receptor, Farnesoid X receptor, NAFLD, Internal medicine, medicine, Animals, Humans, Obesity, lcsh:RC31-1245, Molecular Biology, CEBPα, CCAAT/enhancer-binding protein α, DIO, diet-induced obesity, Cell Biology, Atherosclerosis, Mice, Inbred C57BL, BAT, brown adipose tissue, 030104 developmental biology, Endocrinology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc6f686d41c1a501b1cae42176973abbTest
http://www.sciencedirect.com/science/article/pii/S2212877817309195Test

المؤلفون: Miguel López, Rubén Nogueiras, Xabier Buqué, Maria J. Gonzalez-Rellan, Daniel Beiroa, Patricia Aspichueta, Uxia Fernandez, Begoña Porteiro, Rosalía Gallego, Carlos Dieguez, Guadalupe Sabio, Marcos F. Fondevila, Johan Fernø, Ana Senra, Alfonso Mora

المساهمون: Ministerio de Economía y Competitividad (España), Xunta de Galicia (España), Heise Vest RHF, Comunidad de Madrid (España), Basque Government (España), Fundación AstraZeneca, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Unión Europea. Comisión Europea, Centro de Investigación Biomedica en Red - CIBER

المصدر: Molecular Metabolism, Vol 8, Iss, Pp 132-143 (2018)
Molecular Metabolism
Repisalud
Instituto de Salud Carlos III (ISCIII)

مصطلحات موضوعية: 0301 basic medicine, pIRE, Inositol-requiring enzyme 1 α, pJNK, phospho c-Jun N-terminal kinase, ACC, acetyl-CoA carboxylase, AST, aspartate aminotransferase, XBP1s, X-box binding protein 1, Abcd1, ATP binding cassette subfamily D member 1, Pharmacology, ER stress, endoplasmic reticulum stress, NFκβ, nuclear factor kappa b, FA, free fatty acid, Mice, Liver disease, UPR, unfolded protein response, 0302 clinical medicine, HFD, high fat diet, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, DG, diacylglycerol, Topoisomerase II Inhibitors, IL6, initerleukin 6, Beta oxidation, Acadm, acyl-CoA deshydrogenase, medium chain, GFP, green fluorescent protein, IL10, interleukin 10, Acox, acyl-CoA oxidase 1, TG, triglyceride, Ad, adenovirus, Hep G2 Cells, Acadl, acyl-CoA deshydrogenase, long-chain, i.p., intraperitoneal, FAS, fatty acid synthase, 3. Good health, Liver, Pparα, peroxisome proliferator activated receptor alpha, JNK, c-Jun N-terminal kinase, Lipogenesis, DOX, Doxorubicin, DN, dominant negative, Original Article, ApoB, apolipoprotein b, Quer, quercetin, NAFLD, non-alcoholic fatty liver disease, lcsh:Internal medicine, ASM, acid-soluble metabolites, NASH, non-alcoholic steatohepatitis, TNFα, tumor necrosis factor alpha, GAPDH, glyceraldehyde-3-phosphate deshydrogenase, AUC, area under curve, Diet, High-Fat, Cell Line, SPF, specific pathogen free room, 03 medical and health sciences, GTT, glucose test tolerance, ALT, alanine aminotransferase, AAV8, adeno-associated virus serotype 8, medicine, Animals, Humans, Obesity, EC, sterified cholesterol, lcsh:RC31-1245, Molecular Biology, MCD, methionine-choline deficient diet, CHOP, C/EBP-homologous protein, Inflammation, business.industry, OA, oleic acid, Lipid metabolism, DIO, diet-induced obesity, Cell Biology, Lipid Metabolism, medicine.disease, CDHFD, choline-deficient high fat diet, Mice, Inbred C57BL, 030104 developmental biology, Doxorubicin, pACC, phospho acetyl-CoA carboxylase, Hepatic stellate cell, BSA, bovine serum albumin, Tumor Suppressor Protein p53, Steatohepatitis, Steatosis, business, Fatp2, solute carrier family 27 (fatty acid transporter) member 2, IL1β, interleukin 1beta, 030217 neurology & neurosurgery, ITT, insulin test tolerance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7642e1971aebb46c881386960e7affTest
http://www.sciencedirect.com/science/article/pii/S2212877817310116Test

المؤلفون: Adam J. Rauckhorst, Xiaorong Fu, Katherine N. Gibson-Corley, Alvin D. Pewa, Ryan D. Sheldon, Eric B. Taylor, James E. Cox, Charlotte R. Feddersen, Shawn C. Burgess, Adam J. Dupuy, Lawrence R. Gray

المصدر: Molecular Metabolism, Vol 6, Iss 11, Pp 1468-1479 (2017)
Molecular Metabolism

مصطلحات موضوعية: Blood Glucose, 0301 basic medicine, Mitochondria, Liver, Mitochondrion, Mitochondrial Membrane Transport Proteins, Mice, 0302 clinical medicine, HFD, high fat diet, Fibrosis, immune system diseases, Pyruvic Acid, digestive, oral, and skin physiology, Diabetes, Mitochondria, HOMA-IR, homeostatic model assessment of insulin resistance, medicine.anatomical_structure, Liver, Mitochondrial matrix, 030220 oncology & carcinogenesis, Hepatocyte, Original Article, MPC, mitochondrial pyruvate carrier, TCA, tricarboxylic acid cycle, Monocarboxylic Acid Transporters, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, lcsh:Internal medicine, NASH, non-alcoholic steatohepatitis, Anion Transport Proteins, Citric Acid Cycle, T2D, type 2 diabetes, Biology, Diet, High-Fat, Mitochondrial pyruvate carrier (MPC), 03 medical and health sciences, Internal medicine, medicine, Animals, Obesity, lcsh:RC31-1245, Molecular Biology, ITT, insulin tolerance test, Inflammation, NCD, normal chow diet, Gluconeogenesis, Membrane Transport Proteins, nutritional and metabolic diseases, Cell Biology, Metabolism, medicine.disease, Citric acid cycle, Disease Models, Animal, Cytosol, Glucose, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Hyperglycemia, Hepatocytes, Insulin Resistance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80260421dd9726225c6f9a3cac3cf9faTest
http://www.sciencedirect.com/science/article/pii/S2212877817306828Test

المؤلفون: Thomas Laeger, Louise Fritsche, Christian Baumeier, Norbert Stefan, Annette Schürmann, Sophie Saussenthaler, Andreas Fritsche, Robert W. Schwenk, Maria Rödiger, Hans-Ulrich Häring, Luisa Schlüter, Stella Amelie Alaze

المصدر: Molecular Metabolism
Mol. Metab. 6, 1254-1263 (2017)
Molecular Metabolism, Vol 6, Iss 10, Pp 1254-1263 (2017)

مصطلحات موضوعية: 0301 basic medicine, Male, HFD, high-fat diet, PPARγ, medicine.medical_treatment, CD36, Adipose tissue, AST, aspartate aminotransferase, SM, skeletal muscle, Mice, F4/80, adhesion G protein-coupled receptor E1, GGT, gamma-glutamyl transpeptidase, Non-alcoholic Fatty Liver Disease, Insulin, rmDPP4, recombinant mouse dipeptidyl peptidase 4, rhDPP4, recombinant human dipeptidyl peptidase 4, Fatty liver, Ad, adenovirus, sWAT, subcutaneous white adipose tissue, Hep G2 Cells, Middle Aged, Dgat2, diacylglycerol O-acyltransferase 2, Cd36, Dpp4, Glp-1, Insulin Resistance, Nafld, Pparγ, TNFα, tumor necrosis factor α, Liver, Cpt1a, carnitine palmitoyltransferase 1a, MOGAT1, monoacylglycerol O-acyltransferase 1, Original Article, Female, medicine.symptom, PPARγ, peroxisome proliferator activated receptor gamma, Dpp4-Liv-Tg, transgenic mice with hepatocyte-specific Dpp4 overexpression, NFκB, nuclear factor-κB, Adult, lcsh:Internal medicine, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, Akt, Akt serine–threonine protein kinase, HOMA-IR, homeostatic model assessment for insulin resistance, IL6, interleukin 6, NASH, non-alcoholic steatohepatitis, Dipeptidyl Peptidase 4, gWAT, gonadal white adipose tissue, Inflammation, Srebf1, sterol regulatory element binding transcription factor 1, Mice, Transgenic, Biology, DPP4, 03 medical and health sciences, Insulin resistance, Internal medicine, NAFLD, ALT, alanine aminotransferase, medicine, Animals, Humans, ApoB, apolipoprotein B, GLP-1, glucagon-like peptide 1, Obesity, lcsh:RC31-1245, Molecular Biology, pAkt, phosphorylated Akt serine–threonine protein kinase, Cell Biology, medicine.disease, CD36, fatty acid translocase, DPP4, dipeptidyl peptidase 4, WT, wild-type, BAT, brown adipose tissue, Insulin receptor, Disease Models, Animal, 030104 developmental biology, Endocrinology, biology.protein, Hepatocytes, Gfp, green fluorescent protein, Steatosis, GLP-1, MCP1, chemokine (C-C motif) ligand 2, MAPK, mitogen-activated protein kinase

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec108ccaaae2e081b54e4ea79fe8b459Test

المؤلفون: Annie Ogasawara, James Ziai, Junichiro Sonoda, Joshua C. Chang, Victor Nunez, Minh Thai, Jose Zavala-Solorio, Ganesh Kolumam, Robert J. Newman, Lance Kates, Khanhky Phamluong, Sean Flanagan, Søren Warming, Mark Z. Chen, Xiaobo Bai

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 11, Pp 1454-1467 (2017)

مصطلحات موضوعية: 0301 basic medicine, eWAT, epididymal white adipose tissue, Receptor complex, HFD, high-fat diet, FGF21, FDG, fluorodeoxyglucose, Adipose tissue, Brown adipose tissue, Therapeutic antibody, Mice, AUC, area under the curve, 0302 clinical medicine, Adipose Tissue, Brown, Receptor, Uncoupling Protein 1, Mice, Knockout, Thermogenesis, WAT, white adipose tissue, medicine.anatomical_structure, Adipocytes, Brown, FGFR1, Fibroblast Growth Factor Receptor 1, Original Article, lcsh:Internal medicine, medicine.medical_specialty, Transgene, Adipose Tissue, White, NASH, non-alcoholic steatohepatitis, 030209 endocrinology & metabolism, Mice, Transgenic, Biology, HMW, high molecular weight, Antibodies, Mitochondrial Proteins, KLB, βKlotho, 03 medical and health sciences, Internal medicine, Weight Loss, UCP1, uncoupling protein 1, medicine, Animals, ingWAT, inguinal white adipose tissue, Obesity, Receptor, Fibroblast Growth Factor, Type 1, lcsh:RC31-1245, Molecular Biology, Klotho Proteins, iBAT, interscapular brown adipose tissue, Fibroblast growth factor receptor 1, EE, energy expenditure, Membrane Proteins, Cell Biology, ECD, extracellular domain, Fibroblast Growth Factors, BAT, brown adipose tissue, stomatognathic diseases, 030104 developmental biology, Endocrinology, FGF21, Fibroblast Growth Factor 21, Energy Metabolism, Agonist antibody, MAPK, mitogen-activated protein kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01331d06bde68c629b66d95dda9d735Test
https://pubmed.ncbi.nlm.nih.gov/29107292Test

المؤلفون: Kasper W. ter Horst, Pim W. Gilijamse, Ahmet Demirkiran, Max Nieuwdorp, Joanne Verheij, Mariëtte T. Ackermans, Mireille J. Serlie, Bart A. van Wagensveld, Johannes A. Romijn, Mark A. Herman, Eleftheria Maratos-Flier

المساهمون: Graduate School, Other Research, Laboratory for Endocrinology, Pathology, General Internal Medicine, Amsterdam Cardiovascular Sciences, Amsterdam Gastroenterology Endocrinology Metabolism, Vascular Medicine, Endocrinology, ACS - Diabetes & metabolism, Internal medicine

المصدر: Molecular metabolism, 6(11), 1493-1502. Elsevier GmbH
Molecular Metabolism, 6(11), 1493-1502. Elsevier GmbH
ter Horst, K W, Gilijamse, P W, Demirkiran, A, van Wagensveld, B A, Ackermans, M T, Verheij, J, Romijn, J A, Nieuwdorp, M, Maratos-Flier, E, Herman, M A & Serlie, M J 2017, ' The FGF21 response to fructose predicts metabolic health and persists after bariatric surgery in obese humans ', Molecular Metabolism, vol. 6, no. 11, pp. 1493-1502 . https://doi.org/10.1016/j.molmet.2017.08.014Test
Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 11, Pp 1493-1502 (2017)

مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, FGF21, medicine.medical_treatment, Bariatric Surgery, FGF21, fibroblast growth factor 21, AUC, area under the curve, EGP, endogenous glucose production, chemistry.chemical_compound, 0302 clinical medicine, Weight loss, Insulin, Middle Aged, Fructose Intolerance, Obesity, Morbid, Liver, Female, Original Article, medicine.symptom, Rd, rate of disappearance, Adult, lcsh:Internal medicine, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, ChREBP, carbohydrate response element-binding protein, GLP1, glucagon-like peptide 1, NASH, non-alcoholic steatohepatitis, Gastric Bypass, Translational study, 030209 endocrinology & metabolism, Fructose, Biology, 03 medical and health sciences, Insulin resistance, Internal medicine, Weight Loss, FFA, free fatty acid, medicine, Humans, Obesity, lcsh:RC31-1245, Carbohydrate-responsive element-binding protein, Molecular Biology, IQR, interquartile range, Ra, rate of appearance, Cell Biology, medicine.disease, Fatty Liver, Fibroblast Growth Factors, Glucose, 030104 developmental biology, Endocrinology, chemistry, Hyperinsulinemic-euglycemic clamp, Energy Metabolism, SD, standard deviation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2e659739c9955525826cd9525c9c29Test
https://pure.amc.nl/en/publications/the-fgf21-response-to-fructose-predicts-metabolic-health-and-persists-after-bariatric-surgery-in-obese-humansTest(1b1e6aa9-0f4a-4f37-b984-a10e3cf4e1ba).html