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المؤلفون: Kit‐Kay Mak, Zhang Shiming, Ola Epemolu, Albena T. Dinkova‐Kostova, Geoffrey Wells, Irina G. Gazaryan, Raghavendra Sakirolla, Zulkefeli Mohd, Mallikarjuna Rao Pichika
المصدر: ChemistryOpen. 11
مصطلحات موضوعية: Lipopolysaccharides, Kelch-Like ECH-Associated Protein 1, NF-E2-Related Factor 2, Tumor Necrosis Factor-alpha, Interleukin-6, NF-kappa B, Anti-Inflammatory Agents, Thiophenes, General Chemistry, Dinoprostone, Rats, Mice, Cyclooxygenase 2, Humans, Animals, Cytokines, RNA, Messenger, Inflammation Mediators
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5858605998fcc3df15b9481074bfd558Test
https://doi.org/10.1002/open.202200181Test -
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المؤلفون: Kit-Kay Mak, Zhang Shiming, Jun Sheng Low, Madhu Katyayani Balijepalli, Raghavendra Sakirolla, Albena T. Dinkova-Kostova, Ola Epemolu, Zulkefeli Mohd, Mallikarjuna Rao Pichika
المصدر: Molecules; Volume 27; Issue 15; Pages: 4992
مصطلحات موضوعية: Flavonoids, Lipopolysaccharides, Glycogen Synthase Kinase 3 beta, Kelch-Like ECH-Associated Protein 1, NF-E2-Related Factor 2, Organic Chemistry, Anti-Inflammatory Agents, NF-kappa B, Pharmaceutical Science, Nitric Oxide, Amides, Rats, Analytical Chemistry, Molecular Docking Simulation, Mice, Chemistry (miscellaneous), Drug Discovery, Animals, Cytokines, Humans, Molecular Medicine, Physical and Theoretical Chemistry, Heme Oxygenase-1, auranamide, patriscabratine, Melastoma malabathricum, NRF2, KEAP1, anti-inflammatory
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8826c704a8ff88a56dc443453de3304cTest
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المصدر: STAR protocols. 3(2)
مصطلحات موضوعية: Kelch-Like ECH-Associated Protein 1, General Immunology and Microbiology, NF-E2-Related Factor 2, General Neuroscience, Immunoblotting, Biological Assay, General Biochemistry, Genetics and Molecular Biology, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142ab5e4f8dd8f5c613f72083a1f16dbTest
https://pubmed.ncbi.nlm.nih.gov/35391936Test -
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المؤلفون: Tatsuro Iso, Geoffrey Wells, Seizo Koshiba, Takafumi Suzuki, Takashi Kamei, Albena T. Dinkova-Kostova, Jin Inoue, Yuta Horie, Tsunehiro Mizushima, Terry W. Moore, Masayuki Yamamoto, Takuma Kasai
المصدر: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Communications Biologyمصطلحات موضوعية: 0301 basic medicine, Molecular biology, NF-E2-Related Factor 2, Protein Conformation, QH301-705.5, Hinge, Medicine (miscellaneous), digestive system, environment and public health, Article, General Biochemistry, Genetics and Molecular Biology, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Humans, Protein Interaction Domains and Motifs, Inducer, Biology (General), Binding Sites, Kelch-Like ECH-Associated Protein 1, Mechanism (biology), Chemistry, Nuclear magnetic resonance spectroscopy, respiratory system, Cytoprotection, KEAP1, Keap1 nrf2, 030104 developmental biology, 030220 oncology & carcinogenesis, Biophysics, Disease prevention, General Agricultural and Biological Sciences, Solution-state NMR, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64b389db1174491fece623799eefbceTest
https://doi.org/10.1038/s42003-021-02100-6Test -
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المؤلفون: Steven O′Reilly, Albena T. Dinkova-Kostova, John Henderson, Sharadha Dayalan Naidu, Stefan Przyborski, Richard Stratton
المصدر: Cells, 2021, Vol.10(8) [Peer Reviewed Journal]
Cells; Volume 10; Issue 8; Pages: 2053
Cells
Cells, Vol 10, Iss 2053, p 2053 (2021)مصطلحات موضوعية: QH301-705.5, systemic sclerosis, NF-E2-Related Factor 2, medicine.medical_treatment, Down-Regulation, Article, Nrf2, Transforming Growth Factor beta1, Mice, Downregulation and upregulation, Fibrosis, medicine, NAD(P)H Dehydrogenase (Quinone), Animals, Humans, Biology (General), Interleukin 6, chemistry.chemical_classification, Mice, Knockout, Reactive oxygen species, Scleroderma, Systemic, biology, integumentary system, Interleukin-6, fibrosis, Connective Tissue Growth Factor, Succinates, General Medicine, Transforming growth factor beta, Fibroblasts, medicine.disease, C700, Connective tissue disease, Molecular biology, Antioxidant Response Elements, Up-Regulation, Heme oxygenase, MicroRNAs, Cytokine, chemistry, itaconate, biology.protein, metabolism, Collagen, Reactive Oxygen Species, Heme Oxygenase-1
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca68670e6790373ccb3a2ff9f8bbf0fTest
http://dro.dur.ac.uk/35213Test/ -
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المؤلفون: Eduardo Muñoz, Albena T. Dinkova-Kostova, María E. Prados, Giovanni Apendino, Laura Casares, Juan D. Unciti-Broceta, Maureen Higgins, Laureano de la Vega, Diego Caprioglio, Daiana Mattoteia
المصدر: Redox Biology
Redox Biology, Vol 37, Iss, Pp 101689-(2020)مصطلحات موضوعية: Antioxidant, NF-E2-Related Factor 2, medicine.medical_treatment, Short Communication, Clinical Biochemistry, Inflammation, Pharmacology, medicine.disease_cause, Biochemistry, Neuroprotection, environment and public health, digestive system, Antioxidants, Cannabidiol derivative/ NRF2/ BACH1/ HMOX1/ neurodegenerative diseases, Cell Line, Mice, In vivo, medicine, Animals, lcsh:QH301-705.5, lcsh:R5-920, Chemistry, Multiple sclerosis, Organic Chemistry, Nrf2 activators, Neurodegenerative Diseases, respiratory system, medicine.disease, Disease Models, Animal, Oxidative Stress, Basic-Leucine Zipper Transcription Factors, lcsh:Biology (General), medicine.symptom, lcsh:Medicine (General), Cannabidiol, Oxidative stress, medicine.drug
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de4a453fd64e589b62478d05efde73bTest
https://pubmed.ncbi.nlm.nih.gov/32863231Test -
7KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease
المؤلفون: Sharadha Dayalan Naidu, Albena T. Dinkova-Kostova
المصدر: Open Biology
Open Biology, Vol 10, Iss 6 (2020)مصطلحات موضوعية: Models, Molecular, Proteasome Endopeptidase Complex, antioxidant, NF-E2-Related Factor 2, Immunology, Inflammation, Review, Review Article, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, NRF2, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, medicine, Humans, Molecular Targeted Therapy, lcsh:QH301-705.5, cysteine, Transcription factor, anti-inflammatory, 030304 developmental biology, Clinical Trials as Topic, 0303 health sciences, Kelch-Like ECH-Associated Protein 1, biology, General Neuroscience, Ubiquitination, respiratory system, KEAP1, Cytoprotection, Cell biology, Ubiquitin ligase, lcsh:Biology (General), redox, 030220 oncology & carcinogenesis, Chronic Disease, biology.protein, medicine.symptom, Cullin, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7017809c3d739b04628aa127f1f19a38Test
https://doi.org/10.1098/rsob.200105Test -
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المؤلفون: Luke A. J. O'Neill, Dave Speijer, Esther Lutgens, Michel van Weeghel, Annette E. Neele, Koen H.M. Prange, Saskia van der Velden, Albena T. Dinkova-Kostova, Menno P.J. de Winther, Rob C. I. Wüst, Jeroen Baardman, Maarten E. Witte, Simone Denis, Jan Van den Bossche, Elena V. Knatko, Dylan G. Ryan, Sanne G.S. Verberk, Riekelt H. Houtkooper
المساهمون: Molecular cell biology and Immunology, Physiology, Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Atherosclerosis & ischemic syndromes, Graduate School, Medical Biochemistry, AII - Inflammatory diseases, Laboratory Genetic Metabolic Diseases, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, AMS - Ageing & Morbidty, ACS - Amsterdam Cardiovascular Sciences, AII - Amsterdam institute for Infection and Immunity, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Aging & Later Life, AGEM - Endocrinology, metabolism and nutrition, AGEM - Inborn errors of metabolism, ARD - Amsterdam Reproduction and Development
المصدر: Cell Reports, 25(8), 2044-2052.e5. Cell Press
Baardman, J, Verberk, S G S, Prange, K H M, van Weeghel, M, van der Velden, S, Ryan, D G, Wüst, R C I, Neele, A E, Speijer, D, Denis, S W, Witte, M E, Houtkooper, R H, O'neill, L A, Knatko, E V, Dinkova-Kostova, A T, Lutgens, E, de Winther, M P J & Van den Bossche, J 2018, ' A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia ', Cell Reports, vol. 25, no. 8, pp. 2044-2052.e5 . https://doi.org/10.1016/j.celrep.2018.10.092Test, https://doi.org/10.1016/j.celrep.2018.10.092Test
Cell reports, 25(8), 2044-2052. Cell Press
Cell Reports, Vol 25, Iss 8, Pp 2044-2052.e5 (2018)
Baardman, J, Verberk, S G S, Prange, K H M, van Weeghel, M, van der Velden, S, Ryan, D G, Wüst, R C I, Neele, A E, Speijer, D, Denis, S W, Witte, M E, Houtkooper, R H, O'neill, L A, Knatko, E V, Dinkova-Kostova, A T, Lutgens, E, de Winther, M P J & Van den Bossche, J 2018, ' A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia ', Cell Reports, vol. 25, no. 8, pp. 2044-2052.e5 . https://doi.org/10.1016/j.celrep.2018.10.092Testمصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Male, NF-E2-Related Factor 2, Citric Acid Cycle, immunometabolism, pentose phosphate pathway, Inflammation, Pentose phosphate pathway, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Nrf2, 03 medical and health sciences, 0302 clinical medicine, Immune system, SDG 3 - Good Health and Well-being, cardiovascular disease, medicine, Macrophage, Animals, lcsh:QH301-705.5, hypercholesterolemia, Chemistry, meta-inflammation, Metabolism, metabolic disease, foam cells, Cell biology, macrophages, Mice, Inbred C57BL, 030104 developmental biology, Cell metabolism, lcsh:Biology (General), inflammation, 030220 oncology & carcinogenesis, Cytokine secretion, Female, medicine.symptom, atherosclerosis, Glycolysis, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ef415f4ba7df2f11e9a8a4f10fe79fTest
https://research.vumc.nl/en/publications/18d3e0ec-b7da-4ccb-bcdd-e585bd6780daTest -
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المؤلفون: Albena T. Dinkova-Kostova, Filip Cvetko, Hiran A. Prag, Michael P. Murphy, Stuart T. Caldwell, Maureen Higgins, Takafumi Suzuki, Richard C. Hartley, Masayuki Yamamoto
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, GCLC, glutamate–cysteine ligase catalytic subunit, thiol oxidation, Mitochondrion, Biochemistry, FB, fractionation buffer, NQO1, NAD(P)H:quinone oxidoreductase-1, Mice, chemistry.chemical_compound, DNM1L, Superoxides, energy metabolism, Homeostasis, Hydrogen peroxide, Cells, Cultured, HO-1, heme oxygenase-1, NAC, N-acetyl-L-cysteine, SFN, sulforaphane, chemistry.chemical_classification, Kelch-Like ECH-Associated Protein 1, Nrf2, nuclear factor erythroid 2–related factor 2, respiratory system, DRP1, dynamin-related protein 1, Glutathione, Mitochondria, Cell biology, CDNB, 1-chloro-2,4-dinitrobenzene, Keap1, Kelch-like ECH-associated protein 1, TRX, thioredoxin, Thioredoxin, Oxidation-Reduction, Research Article, Signal Transduction, NF-E2-Related Factor 2, reactive oxygen species (ROS), Nrf2, MitoPQ, MitoParaquat, 03 medical and health sciences, MitoCDNB, CD, concentration required to double, ROS, reactive oxygen species, PGAM5, phosphoglycerate mutase family member 5, Animals, TRXR2, TRX reductase 2, Cysteine, Sulfhydryl Compounds, redox signaling, Molecular Biology, Reactive oxygen species, 030102 biochemistry & molecular biology, Cell Biology, ACN, acetonitrile, MitoCDNB, MitoChlorodinitrobenzoic acid, GSS, GSH synthetase, MEF, mouse embryonic fibroblast, KEAP1, 030104 developmental biology, chemistry, BSA, bovine serum albumin, MitoPQ
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0523882756133409621203d90cd5225Test
https://doi.org/10.1074/jbc.ra120.016551Test -
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المؤلفون: Albena T. Dinkova-Kostova, Jean A. Quinn, Joanne Edwards, Laura Casares, Gunjit Maan, Laura Torrente, Angus W. Jackson, Silvio Bicciato, Ying Zhang, Jani Saarela, Laureano de la Vega, Evgeny Kulesskiy, Asma Oumkaltoum Rezig, Andrea Grilli
المساهمون: Institute for Molecular Medicine Finland, University of Helsinki, Biosciences
المصدر: Biomolecules, Vol 10, Iss 1365, p 1365 (2020)
Biomoleculesمصطلحات موضوعية: 0301 basic medicine, POTENT AURORA KINASE, Colorectal cancer, Drug Evaluation, Preclinical, lcsh:QR1-502, environment and public health, Biochemistry, lcsh:Microbiology, NEGATIVE REGULATION, PATHWAY, 0302 clinical medicine, Urea, Medicine, Drug screening, NRF2, SMALL-MOLECULE INHIBITOR, Hyperactivation, Kinase, Communication, TUMOR-GROWTH, respiratory system, 3. Good health, Gene Expression Regulation, Neoplastic, PHASE-I, 030220 oncology & carcinogenesis, Colorectal Neoplasms, Signal Transduction, EXPRESSION, Cell Survival, NF-E2-Related Factor 2, In silico, Aurora inhibitor, colorectal cancer, digestive system, 03 medical and health sciences, Downregulation and upregulation, Cell Line, Tumor, Humans, LUNG-CARCINOMA, drug screening, Protein Kinase Inhibitors, Molecular Biology, Cell Proliferation, business.industry, medicine.disease, KEAP1, 030104 developmental biology, Drug Resistance, Neoplasm, Cell culture, Cancer cell, Cancer research, 1182 Biochemistry, cell and molecular biology, Benzimidazoles, 3111 Biomedicine, business, RESISTANCE
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db5a8ccdf6881c79812ba3a75b4bdf6Test
https://doi.org/10.3390/biom10101365Test
