نتائج البحث - "Albena T Dinkova-Kostova"

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 367-398 (2018)

مصطلحات موضوعية: NQO1, NAD(P)H:quinone oxidoreductase 1, TNF-α, tumor necrosis factor-α, IRE1α, inositol requiring kinase-1α, SCAD, short-chain acyl-CoA dehydrogenase, C/EBP, CCAAT/enhancer-binding protein, PCR, polymerase chain reaction, UPR, unfolded protein response, 0302 clinical medicine, Fibrosis, MGPAT, mitochondrial glycerol-3-phosphate acetyltransferase, ATF4, activating transcription factor-4, DGAT2, diacylglycerol acyltransferase-2, LXRα, liver X receptor α, Glucose homeostasis, eIf2α, eukaryotic translation initiation factor 2A, IKK, IκB kinase, ACOT7, acetyl-CoA thioesterase 7, Original Research, TGFβ, transforming growth factor beta-1, SLC7A11, solute carrier family 7 member 11, GSSG, oxidized glutathione, MTTP, microsomal triglyceride transfer protein, NASH, Gastroenterology, TXN1, thioredoxin-1, 3. Good health, ChREBP, carbohydrate-responsive element-binding protein, 030220 oncology & carcinogenesis, NASH, nonalcoholic steatohepatitis, medicine.medical_specialty, PARP, poly ADP ribose polymerase, qRT-PCR, quantitative reverse transcriptase PCR, GSTM1, glutathione S-transferase Mu-1, GCLC, glutamate-cysteine ligase catalytic, Nrf2, ACACA, acetyl-CoA carboxylase alpha, 03 medical and health sciences, FXR, farnesoid X receptor, Nrf2, NF-E2 p45-related factor 2, COX2, cyclooxygenase-2, Keap1, Kelch-like ECH-associated protein-1, PPARα, peroxisome proliferator-activated receptor α, PTT, pyruvate tolerance test, HMOX1, heme oxygenase-1, RC, regular chow, p58IPK, p58 inhibitor of the PKR kinase, medicine.disease, TBE-31, 030104 developmental biology, Endocrinology, COL1A1, collagen, type I, alpha-1, Unfolded protein response, CAT, catalase, 0301 basic medicine, PDI, protein disulfide isomerase, GSH, reduced glutathione, FASN, fatty acid synthase, BCL-2, B-cell lymphoma, MPO, myeloperoxidase, AP-1, activator protein 1, DMSO, dimethyl sulfoxide, medicine.disease_cause, SHP, small heterodimer partner, CDDO, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid, CHOP, C/EBP homologous protein, TXNRD1, thioredoxin reductase-1, HF30Fr, high-fat diet with 30% fructose in drinking water, IκB, inhibitor of NF-κB, SFN, sulforaphane, ADRP, adipose differentiation-related protein, NAS, NAFLD activity score, GPX2, glutathione peroxidase-2, Chemistry, MCP-1, monocyte chemotactic protein-1, XBP1, X-box binding protein-1, SREBP-1c, sterol regulatory element-binding protein-1c, Lipogenesis, GTT, glucose tolerance test, PERK, PRK-like endoplasmic reticulum kinase, PTGR1, prostaglandin reductase-1, GSTA4, glutathione S-transferase Alpha-4, medicine.symptom, NAFLD, non-alcoholic fatty liver disease, α-SMA, alpha smooth muscle actin, ACOX2, acetyl-CoA oxidase 2, HFFr, high-fat diet with fructose in drinking water, NF-κB, nuclear factor-κB, GCLM, glutamate-cysteine ligase modifier, Inflammation, JNK1, c-Jun N-terminal kinase 1, CD36, cluster of differentiation 36, ER, endoplasmic reticulum, Insulin resistance, HF, high-fat, HF55Fr, high-fat diet with 55% fructose in drinking water, Internal medicine, ATF6, activating transcription factor-6, medicine, ApoB, apolipoprotein B, lcsh:RC799-869, CES1G, carboxylesterase 1g, ITT, insulin tolerance test, MCD, methionine- and choline-deficient, ACLY, ATP citrate lyase, Hepatology, SCD1, stearoyl-CoA desaturase-1, NOS2, nitric oxide synthase-2, PRDX6, peroxiredoxin 6, PPARγ, peroxisome proliferator-activated receptor γ, BIP, binding immunoglobulin protein, H&E, hematoxylin and eosin, lcsh:Diseases of the digestive system. Gastroenterology, Steatosis, CPT1A, carnitine palmitoyltransferase 1a, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdd8de56b5ba950a8c970d72cce7012Test
https://doi.org/10.1016/j.jcmgh.2017.11.016Test

7

372-P: Activation of the Nrf2 Pathway Provides Protection against Hypoglycaemia-Induced Cognitive Impairment in a Rodent Model of Type 1 Diabetes

المؤلفون: Jennifer E. Gallagher, Alison D. McNeilly, Rory J. McCrimmon, Albena T. Dinkova-Kostova

المصدر: Diabetes. 68

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7f0252158b5482465a4ffdcab9966694Test
https://doi.org/10.2337/db19-372-pTest

8

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mouse model

المؤلفون: W. David Holtzclaw, Jay H. Kalin, Abdulkerim Eroglu, Albena T. Dinkova-Kostova, Hua Liu, Charlotte M. Proby, Irene M. Leigh, Jed W. Fahey, Philip A. Cole

المصدر: PLoS ONE
PLoS ONE, Vol 14, Iss 3, p e0213095 (2019)

مصطلحات موضوعية: Neoplasms, Radiation-Induced, Skin Neoplasms, Light, Carcinogenesis, Pyridines, Administration, Topical, Cell, Cancer Treatment, Gene Expression, medicine.disease_cause, Biochemistry, Histones, 030207 dermatology & venereal diseases, Mice, 0302 clinical medicine, Medicine and Health Sciences, Post-Translational Modification, Multidisciplinary, integumentary system, Chromosome Biology, Physics, Chromatin Modification, Histone deacetylase inhibitor, Chemical Reactions, Squamous Cell Carcinomas, Acetylation, Histone Modification, Animal Models, Chromatin, 3. Good health, Tumor Burden, Physical sciences, Gene Expression Regulation, Neoplastic, Chemistry, medicine.anatomical_structure, Oncology, Experimental Organism Systems, 030220 oncology & carcinogenesis, Benzamides, Carcinoma, Squamous Cell, Medicine, Epigenetics, Keratinocyte, Research Article, Ultraviolet radiation, Cyclin-Dependent Kinase Inhibitor p21, medicine.drug_class, Cell Survival, Science, Histone Acetylation, Mouse Models, Research and Analysis Methods, Carcinomas, 03 medical and health sciences, Model Organisms, Electromagnetic radiation, Cell Line, Tumor, DNA-binding proteins, Carcinoma, medicine, Genetics, Animals, Humans, Cell Proliferation, Mice, Hairless, Biology and life sciences, business.industry, Proteins, Cancers and Neoplasms, Cell Biology, medicine.disease, Xenograft Model Antitumor Assays, Hairless, Histone Deacetylase Inhibitors, Cancer research, Animal Studies, Histone deacetylase, business, Ultraviolet B

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5541a74e2e97503f7eb40aac73e20c52Test
http://europepmc.org/articles/PMC6415858Test

9

High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

المؤلفون: Albena T. Dinkova-Kostova, Jean A. Quinn, Joanne Edwards, Laura Casares, Gunjit Maan, Laura Torrente, Angus W. Jackson, Silvio Bicciato, Ying Zhang, Jani Saarela, Laureano de la Vega, Evgeny Kulesskiy, Asma Oumkaltoum Rezig, Andrea Grilli

المساهمون: Institute for Molecular Medicine Finland, University of Helsinki, Biosciences

المصدر: Biomolecules, Vol 10, Iss 1365, p 1365 (2020)
Biomolecules

مصطلحات موضوعية: 0301 basic medicine, POTENT AURORA KINASE, Colorectal cancer, Drug Evaluation, Preclinical, lcsh:QR1-502, environment and public health, Biochemistry, lcsh:Microbiology, NEGATIVE REGULATION, PATHWAY, 0302 clinical medicine, Urea, Medicine, Drug screening, NRF2, SMALL-MOLECULE INHIBITOR, Hyperactivation, Kinase, Communication, TUMOR-GROWTH, respiratory system, 3. Good health, Gene Expression Regulation, Neoplastic, PHASE-I, 030220 oncology & carcinogenesis, Colorectal Neoplasms, Signal Transduction, EXPRESSION, Cell Survival, NF-E2-Related Factor 2, In silico, Aurora inhibitor, colorectal cancer, digestive system, 03 medical and health sciences, Downregulation and upregulation, Cell Line, Tumor, Humans, LUNG-CARCINOMA, drug screening, Protein Kinase Inhibitors, Molecular Biology, Cell Proliferation, business.industry, medicine.disease, KEAP1, 030104 developmental biology, Drug Resistance, Neoplasm, Cell culture, Cancer cell, Cancer research, 1182 Biochemistry, cell and molecular biology, Benzimidazoles, 3111 Biomedicine, business, RESISTANCE

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db5a8ccdf6881c79812ba3a75b4bdf6Test
https://doi.org/10.3390/biom10101365Test

10

Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species

المؤلفون: Ali Gorji, Albena T Dinkova Kostova, Stjepana Kovac, Nico Melzer, Sven G. Meuth, Alexander M. Herrmann

المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 9, p 1935 (2017)

مصطلحات موضوعية: 0301 basic medicine, Review, Pharmacology, Mitochondrion, medicine.disease_cause, Endoplasmic Reticulum, Epileptogenesis, lcsh:Chemistry, Epilepsy, 0302 clinical medicine, Adenosine Triphosphate, Calcium dynamics, Homeostasis, lcsh:QH301-705.5, Spectroscopy, chemistry.chemical_classification, reactive oxygen species, Cell Death, Acquired epilepsy, General Medicine, Computer Science Applications, Mitochondria, NF-E2-Related Factor 2, Biology, Catalysis, Nrf2, Inorganic Chemistry, 03 medical and health sciences, Seizures, medicine, Animals, Humans, Physical and Theoretical Chemistry, Molecular Biology, Reactive oxygen species, calcium, Research, Organic Chemistry, Cell Membrane, medicine.disease, Oxidative Stress, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, chemistry, Calcium Channels, Energy Metabolism, Neuroscience, 030217 neurology & neurosurgery, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b99ddf0d7d6afa74ce83f70daa6f9dTest
https://pubmed.ncbi.nlm.nih.gov/28885567Test

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