المؤلفون: Miguel López, Rubén Nogueiras, Xabier Buqué, Maria J. Gonzalez-Rellan, Daniel Beiroa, Patricia Aspichueta, Uxia Fernandez, Begoña Porteiro, Rosalía Gallego, Carlos Dieguez, Guadalupe Sabio, Marcos F. Fondevila, Johan Fernø, Ana Senra, Alfonso Mora

المساهمون: Ministerio de Economía y Competitividad (España), Xunta de Galicia (España), Heise Vest RHF, Comunidad de Madrid (España), Basque Government (España), Fundación AstraZeneca, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Unión Europea. Comisión Europea, Centro de Investigación Biomedica en Red - CIBER

المصدر: Molecular Metabolism, Vol 8, Iss, Pp 132-143 (2018)
Molecular Metabolism
Repisalud
Instituto de Salud Carlos III (ISCIII)

مصطلحات موضوعية: 0301 basic medicine, pIRE, Inositol-requiring enzyme 1 α, pJNK, phospho c-Jun N-terminal kinase, ACC, acetyl-CoA carboxylase, AST, aspartate aminotransferase, XBP1s, X-box binding protein 1, Abcd1, ATP binding cassette subfamily D member 1, Pharmacology, ER stress, endoplasmic reticulum stress, NFκβ, nuclear factor kappa b, FA, free fatty acid, Mice, Liver disease, UPR, unfolded protein response, 0302 clinical medicine, HFD, high fat diet, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, DG, diacylglycerol, Topoisomerase II Inhibitors, IL6, initerleukin 6, Beta oxidation, Acadm, acyl-CoA deshydrogenase, medium chain, GFP, green fluorescent protein, IL10, interleukin 10, Acox, acyl-CoA oxidase 1, TG, triglyceride, Ad, adenovirus, Hep G2 Cells, Acadl, acyl-CoA deshydrogenase, long-chain, i.p., intraperitoneal, FAS, fatty acid synthase, 3. Good health, Liver, Pparα, peroxisome proliferator activated receptor alpha, JNK, c-Jun N-terminal kinase, Lipogenesis, DOX, Doxorubicin, DN, dominant negative, Original Article, ApoB, apolipoprotein b, Quer, quercetin, NAFLD, non-alcoholic fatty liver disease, lcsh:Internal medicine, ASM, acid-soluble metabolites, NASH, non-alcoholic steatohepatitis, TNFα, tumor necrosis factor alpha, GAPDH, glyceraldehyde-3-phosphate deshydrogenase, AUC, area under curve, Diet, High-Fat, Cell Line, SPF, specific pathogen free room, 03 medical and health sciences, GTT, glucose test tolerance, ALT, alanine aminotransferase, AAV8, adeno-associated virus serotype 8, medicine, Animals, Humans, Obesity, EC, sterified cholesterol, lcsh:RC31-1245, Molecular Biology, MCD, methionine-choline deficient diet, CHOP, C/EBP-homologous protein, Inflammation, business.industry, OA, oleic acid, Lipid metabolism, DIO, diet-induced obesity, Cell Biology, Lipid Metabolism, medicine.disease, CDHFD, choline-deficient high fat diet, Mice, Inbred C57BL, 030104 developmental biology, Doxorubicin, pACC, phospho acetyl-CoA carboxylase, Hepatic stellate cell, BSA, bovine serum albumin, Tumor Suppressor Protein p53, Steatohepatitis, Steatosis, business, Fatp2, solute carrier family 27 (fatty acid transporter) member 2, IL1β, interleukin 1beta, 030217 neurology & neurosurgery, ITT, insulin test tolerance

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7642e1971aebb46c881386960e7affTest
http://www.sciencedirect.com/science/article/pii/S2212877817310116Test

المؤلفون: Anika Nier, Ina Bergheim, Amélia Camarinha-Silva, Cheng Jun Jin, Annette Brandt, Anja Baumann, Angélica Hernández-Arriaga, Dragana Rajcic, Victor Sánchez, Finn Jung

المصدر: Redox Biology
Redox Biology, Vol 41, Iss, Pp 101879-(2021)

مصطلحات موضوعية: 0301 basic medicine, Medicine (General), F, fructose, Arginine, Clinical Biochemistry, AST, aspartate aminotransferase, Biochemistry, Mice, AUC, area under the curve, NOHA, N(ω)-hydroxy-nor-l-arginine, Liver disease, chemistry.chemical_compound, PCR, polymerase chain reaction, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, ARG2, arginase 2, 3-NT, 3-nitrotyrosine, Citrulline, Biology (General), NAS, NAFLD activity score, Fatty liver, FFC, fat-, fructose- and cholesterol-rich diet, L-Cit, l-citrulline, Arginase, medicine.anatomical_structure, Liver, iNOS, inducible nitric oxide synthase, Female, Research Paper, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, QH301-705.5, C, control diet, NASH, non-alcoholic steatohepatitis, TNFα, tumor necrosis factor alpha, Intestinal permeability, Diet, High-Fat, SEM, standard error of the mean, NO, 03 medical and health sciences, R5-920, Tlr4, toll-like receptor 4, 4-HNE, 4-hydroxynonenal, ALT, alanine aminotransferase, Internal medicine, medicine, Animals, Hepatic inflammation, Gpr41, G-protein-coupled receptor 41, NO, nitric oxide, business.industry, Bacterial endotoxin, Organic Chemistry, E%, percentage of energy, medicine.disease, ZO-1, zonula occludens 1, Small intestine, GTT, glucose-tolerance-test, Mice, Inbred C57BL, Toll-Like Receptor 4, 030104 developmental biology, Endocrinology, chemistry, Dietary Supplements, Myd88, myeloid differentiation primary response 88, Gpr43, G-protein-coupled receptor 43, Steatohepatitis, business, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c29ebb68a39a4a69ad56089e73e70eTest
https://doi.org/10.1016/j.redox.2021.101879Test

المؤلفون: Guangyuan Zhang, Mitsuru Shimamura, Hitoshi Torii, Hideki Kizawa, Eri Nagao

المصدر: Biochemistry and Biophysics Reports, Vol 10, Iss C, Pp 186-191 (2017)
Biochemistry and Biophysics Reports

مصطلحات موضوعية: 0301 basic medicine, OAT, organic anion-transporting, medicine.medical_treatment, Biophysics, 02 engineering and technology, Biology, Biochemistry, Dex, Dexamethasone, lcsh:Biochemistry, 03 medical and health sciences, Liver disease, 8CPT-cAMP, 8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate, ECM, Extracellular matrix, MRP2, multidrug resistance-associated protein 2, medicine, lcsh:QD415-436, Protein kinase A signaling, lcsh:QH301-705.5, NASH, Non-alcoholic steatohepatitis, Bile duct, Bio-printing, Drug discovery, Insulin, HE, hematoxylin and eosin, Lipid metabolism, TUNEL, TdT-mediated dUTP nick end labeling, NAFLD, Non-alcoholic fatty liver disease, 021001 nanoscience & nanotechnology, medicine.disease, MT, Masson's trichrome, 030104 developmental biology, medicine.anatomical_structure, Metabolism, Drug development, Liver, lcsh:Biology (General), Toxicity, Scaffold-free, Liver function, 0210 nano-technology, Research Article, 3D

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c88df6cecf9c5b28a9b3ee07531addcTest
http://www.sciencedirect.com/science/article/pii/S2405580817300596Test

المؤلفون: Bricambert, Julien, Alves-Guerra, Marie-Clotilde, Esteves, Pauline, Prip-Buus, Carina, Bertrand-Michel, Justine, Guillou, Hervé, Chang, Christopher J., Vander Wal, Mark N., Canonne-Hergaux, François, Mathurin, Philippe, Raverdy, Violeta, Pattou, François, Girard, Jean, Postic, Catherine, Dentin, Renaud

المساهمون: Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche en Santé Digestive (IRSD ), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Claude Huriez [Lille], CHU Lille, Service de chirurgie générale et endocrinienne, CHU Lille-CHU Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire de Biologie Intégrative des Modèles Marins (LBI2M), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Prip-Buus, Carina, UMR 1048-12MC, Institut National de la Santé et de la Recherche Médicale (INSERM), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Hôpital Claude Huriez, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Claude Huriez-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), MetaToul-MetaboHUB, Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Toxicologie Intégrative & Métabolisme (ToxAlim-TIM), ToxAlim (ToxAlim), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), University of California [Berkeley], University of California, Centre de Physiopathologie Toulouse Purpan (CPTP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Génomique Intégrative et Modélisation des Maladies Métaboliques (EGID), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Plateforme MetaToul, MetaboHUB, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS), Recherche translationnelle sur le diabète (RTD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut Européen de Génomique du Diabète - EGID, Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: Nature Communications
Nature Communications, 2018, 9 (1), ⟨10.1038/s41467-018-04361-y⟩
Nature communications, vol 9, iss 1
Nature Communications, Nature Publishing Group, 2018, 9 (1), ⟨10.1038/s41467-018-04361-y⟩
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Frontiers in Genetics
Nature Communications 1 (9), . (2018)
Bricambert, J; Alves-Guerra, M-C; Esteves, P; Prip-Buus, C; Bertrand-Michel, J; Guillou, H; et al.(2018). The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity. NATURE COMMUNICATIONS, 9. doi: 10.1038/s41467-018-04361-y. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/1350n6p7Test

مصطلحات موضوعية: Male, [SDV]Life Sciences [q-bio], epigenetics (MeSH), Inbred C57BL, NAFLD (non-alcoholic fatty liver disease), Histones, Pentose Phosphate Pathway, Mice, Non-alcoholic Fatty Liver Disease, 2.1 Biological and endogenous factors, histone modification, Phf2, Aetiology, lcsh:Science, Promoter Regions, Genetic, Cells, Cultured, Cancer, Mice, Knockout, Histone Demethylases, Cultured, General Commentary, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Liver Disease, Nuclear Proteins, Glutathione, [SDV] Life Sciences [q-bio], Liver, Alimentation et Nutrition, NF-E2-Related Factor 2, Science, Cells, Knockout, Chronic Liver Disease and Cirrhosis, Methylation, Article, Promoter Regions, Genetic, Genetics, Food and Nutrition, Animals, Humans, NASH (non-alcoholic steatohepatitis), Obesity, Metabolic and endocrine, Nutrition, Homeodomain Proteins, Prevention, Demethylation, Mice, Inbred C57BL, Enzyme Activation, Oxidative Stress, Glucose, lcsh:Q, Digestive Diseases, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4bd1d2c0617160f15d8e41c9b32d7b80Test
https://hal.science/hal-02122655Test

المؤلفون: Yemi Oluboyede, Gulnar Fattakhova, Lorraine McSweeney, Luke Vale, Lynda C. Doward, Fiona Beyer, Clifford A. Brass, Quentin M. Anstee, Matthew Breckons, Laura Ternent, Maria-Magdalena Balp, Arun J. Sanyal

المصدر: JHEP Reports
JHEP Reports, Vol 2, Iss 3, Pp-(2020)

مصطلحات موضوعية: medicine.medical_treatment, Disease, Liver disease, 0302 clinical medicine, Immunology and Allergy, 030212 general & internal medicine, Non-alcoholic steatohepatitis, education.field_of_study, Gastroenterology, PRO, patient-reported outcome, LDSI, liver disease symptom index, 3. Good health, health-related quality of life, Cirrhosis, 030211 gastroenterology & hepatology, Patient-reported outcome, SF-36, short form health profile 36, Research Article, FDA, United States Food and Drug Administration, RI, researcher interpretation, HRQoL, health-related quality of life, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, SF-36, NASH, non-alcoholic steatohepatitis, Population, liver, digestive system, Support group, MS, multiple sclerosis, 03 medical and health sciences, Quality of life (healthcare), NAFLD, PHAQ, patient-reported outcome measurement information system health assessment questionnaire, Internal Medicine, medicine, NAFL, non-alcoholic fatty liver, CLDQ, chronic liver disease questionnaire, lcsh:RC799-869, Intensive care medicine, education, patient-reported outcome measures, Hepatology, business.industry, nutritional and metabolic diseases, medicine.disease, QoL, quality of life, Mental health, digestive system diseases, FIS, fatigue impact scale, PROM, patient-reported outcome measure, EMA, European Medicines Agency, COSMIN, The COnsensus-based Standards for the selection of health Measurement INstruments, lcsh:Diseases of the digestive system. Gastroenterology, business, LDQoL, liver disease quality of life questionnaire

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee751f2b6ffd99b10142118b951f0fcdTest
https://doi.org/10.1016/j.jhepr.2020.100099Test