نتائج البحث - "Albena T Dinkova-Kostova"

1

دورية أكاديمية

Anti-Inflammatory Effects of Auranamide and Patriscabratine—Mechanisms and In Silico Studies

المؤلفون: Kit-Kay Mak, Zhang Shiming, Jun Sheng Low, Madhu Katyayani Balijepalli, Raghavendra Sakirolla, Albena T. Dinkova-Kostova, Ola Epemolu, Zulkefeli Mohd, Mallikarjuna Rao Pichika

المصدر: Molecules; Volume 27; Issue 15; Pages: 4992

مصطلحات موضوعية: auranamide, patriscabratine, Melastoma malabathricum, NRF2, KEAP1, anti-inflammatory

جغرافية الموضوع: agris

وصف الملف: application/pdf

العلاقة: Natural Products Chemistry; https://dx.doi.org/10.3390/molecules27154992Test

الإتاحة: https://doi.org/10.3390/molecules27154992Test

View record in BASE

2

دورية أكاديمية

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease

المؤلفون: Sharadha Dayalan Naidu, Albena T. Dinkova-Kostova

المصدر: Open Biology, Vol 10, Iss 6 (2020)

مصطلحات موضوعية: keap1, nrf2, cysteine, anti-inflammatory, antioxidant, redox, Biology (General), QH301-705.5

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2046-2441Test

الوصول الحر: https://doaj.org/article/c5acd0ef8f23493ba09ecad96169f537Test

View record in DOAJ

النص الكامل

3

دورية أكاديمية

NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis

المؤلفون: Holly Robertson, Albena T. Dinkova-Kostova, John D. Hayes

المصدر: Cancers; Volume 12; Issue 12; Pages: 3609

مصطلحات موضوعية: NRF2, KEAP1, Cullin 3, ATF4, oxidative stress, reactive oxygen species, antioxidant, adaptation, glutathione, thioredoxin, NADPH generation, pentose phosphate pathway, proteasome, autophagy, drug metabolism, chemoprevention, chemotherapy, bioactivation, quinone-containing drugs, drug resistance, oncogene, tumour suppressor, initiation, progression, metastasis, recurrent disease, lung, oesophagus, liver, head and neck

وصف الملف: application/pdf

العلاقة: Molecular Cancer Biology; https://dx.doi.org/10.3390/cancers12123609Test

الإتاحة: https://doi.org/10.3390/cancers12123609Test

View record in BASE

4

Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism

المؤلفون: Tatsuro Iso, Geoffrey Wells, Seizo Koshiba, Takafumi Suzuki, Takashi Kamei, Albena T. Dinkova-Kostova, Jin Inoue, Yuta Horie, Tsunehiro Mizushima, Terry W. Moore, Masayuki Yamamoto, Takuma Kasai

المصدر: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Communications Biology

مصطلحات موضوعية: 0301 basic medicine, Molecular biology, NF-E2-Related Factor 2, Protein Conformation, QH301-705.5, Hinge, Medicine (miscellaneous), digestive system, environment and public health, Article, General Biochemistry, Genetics and Molecular Biology, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Humans, Protein Interaction Domains and Motifs, Inducer, Biology (General), Binding Sites, Kelch-Like ECH-Associated Protein 1, Mechanism (biology), Chemistry, Nuclear magnetic resonance spectroscopy, respiratory system, Cytoprotection, KEAP1, Keap1 nrf2, 030104 developmental biology, 030220 oncology & carcinogenesis, Biophysics, Disease prevention, General Agricultural and Biological Sciences, Solution-state NMR, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64b389db1174491fece623799eefbceTest
https://doi.org/10.1038/s42003-021-02100-6Test

5

دورية أكاديمية

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

المؤلفون: Kira M. Holmström, Liam Baird, Ying Zhang, Iain Hargreaves, Annapurna Chalasani, John M. Land, Lee Stanyer, Masayuki Yamamoto, Albena T. Dinkova-Kostova, Andrey Y. Abramov

المصدر: Biology Open, Vol 2, Iss 8, Pp 761-770 (2013)

مصطلحات موضوعية: Nrf2, Keap1, Energy metabolism, Oxidative phosphorylation, Mitochondria, Science, Biology (General), QH301-705.5

العلاقة: http://bio.biologists.org/content/2/8/761Test; https://doaj.org/toc/2046-6390Test; https://doaj.org/article/26dac259a99f41a389e0e6b0bb732556Test

الإتاحة: https://doi.org/10.1242/bio.20134853Test
https://doaj.org/article/26dac259a99f41a389e0e6b0bb732556Test

View record in BASE

النص الكامل

6

Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production

المؤلفون: Albena T. Dinkova-Kostova, Filip Cvetko, Hiran A. Prag, Michael P. Murphy, Stuart T. Caldwell, Maureen Higgins, Takafumi Suzuki, Richard C. Hartley, Masayuki Yamamoto

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, GCLC, glutamate–cysteine ligase catalytic subunit, thiol oxidation, Mitochondrion, Biochemistry, FB, fractionation buffer, NQO1, NAD(P)H:quinone oxidoreductase-1, Mice, chemistry.chemical_compound, DNM1L, Superoxides, energy metabolism, Homeostasis, Hydrogen peroxide, Cells, Cultured, HO-1, heme oxygenase-1, NAC, N-acetyl-L-cysteine, SFN, sulforaphane, chemistry.chemical_classification, Kelch-Like ECH-Associated Protein 1, Nrf2, nuclear factor erythroid 2–related factor 2, respiratory system, DRP1, dynamin-related protein 1, Glutathione, Mitochondria, Cell biology, CDNB, 1-chloro-2,4-dinitrobenzene, Keap1, Kelch-like ECH-associated protein 1, TRX, thioredoxin, Thioredoxin, Oxidation-Reduction, Research Article, Signal Transduction, NF-E2-Related Factor 2, reactive oxygen species (ROS), Nrf2, MitoPQ, MitoParaquat, 03 medical and health sciences, MitoCDNB, CD, concentration required to double, ROS, reactive oxygen species, PGAM5, phosphoglycerate mutase family member 5, Animals, TRXR2, TRX reductase 2, Cysteine, Sulfhydryl Compounds, redox signaling, Molecular Biology, Reactive oxygen species, 030102 biochemistry & molecular biology, Cell Biology, ACN, acetonitrile, MitoCDNB, MitoChlorodinitrobenzoic acid, GSS, GSH synthetase, MEF, mouse embryonic fibroblast, KEAP1, 030104 developmental biology, chemistry, BSA, bovine serum albumin, MitoPQ

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0523882756133409621203d90cd5225Test
https://doi.org/10.1074/jbc.ra120.016551Test

7

Downregulation of Keap1 Confers Features of a Fasted Metabolic State

المؤلفون: Michael H. Tatham, Albena T. Dinkova-Kostova, Elena V. Knatko, Tadashi Honda, Cecilia Castro, Maureen Higgins, Laureano de la Vega, Sharadha Dayalan Naidu, Julian L. Griffin, Chiara Leonardi, Ronald T. Hay, Ying Zhang

المصدر: iScience, Vol 23, Iss 10, Pp 101638-(2020)
iScience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474a48655cb0678df2cf46e5d1ad28ebTest
https://doi.org/10.1016/j.isci.2020.101638Test

8

High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

المؤلفون: Albena T. Dinkova-Kostova, Jean A. Quinn, Joanne Edwards, Laura Casares, Gunjit Maan, Laura Torrente, Angus W. Jackson, Silvio Bicciato, Ying Zhang, Jani Saarela, Laureano de la Vega, Evgeny Kulesskiy, Asma Oumkaltoum Rezig, Andrea Grilli

المساهمون: Institute for Molecular Medicine Finland, University of Helsinki, Biosciences

المصدر: Biomolecules, Vol 10, Iss 1365, p 1365 (2020)
Biomolecules

مصطلحات موضوعية: 0301 basic medicine, POTENT AURORA KINASE, Colorectal cancer, Drug Evaluation, Preclinical, lcsh:QR1-502, environment and public health, Biochemistry, lcsh:Microbiology, NEGATIVE REGULATION, PATHWAY, 0302 clinical medicine, Urea, Medicine, Drug screening, NRF2, SMALL-MOLECULE INHIBITOR, Hyperactivation, Kinase, Communication, TUMOR-GROWTH, respiratory system, 3. Good health, Gene Expression Regulation, Neoplastic, PHASE-I, 030220 oncology & carcinogenesis, Colorectal Neoplasms, Signal Transduction, EXPRESSION, Cell Survival, NF-E2-Related Factor 2, In silico, Aurora inhibitor, colorectal cancer, digestive system, 03 medical and health sciences, Downregulation and upregulation, Cell Line, Tumor, Humans, LUNG-CARCINOMA, drug screening, Protein Kinase Inhibitors, Molecular Biology, Cell Proliferation, business.industry, medicine.disease, KEAP1, 030104 developmental biology, Drug Resistance, Neoplasm, Cell culture, Cancer cell, Cancer research, 1182 Biochemistry, cell and molecular biology, Benzimidazoles, 3111 Biomedicine, business, RESISTANCE

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db5a8ccdf6881c79812ba3a75b4bdf6Test
https://doi.org/10.3390/biom10101365Test

9

Oncogene-Stimulated Congestion at the KEAP1 Stress Signaling Hub Allows Bypass of NRF2 and Induction of NRF2-Target Genes that Promote Tumor Survival

المؤلفون: John D. Hayes, Albena T. Dinkova-Kostova

المصدر: Cancer cell. 32(5)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef48c39e6257f18a27ee33f2fabf5fcTest
https://pubmed.ncbi.nlm.nih.gov/29033244Test

10

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

المؤلفون: Lee Stanyer, Annapurna Chalasani, Andrey Y. Abramov, Kira M. Holmström, Ying Zhang, Iain P. Hargreaves, Masayuki Yamamoto, Liam Baird, John M. Land, Albena T. Dinkova-Kostova

المصدر: Biology Open, Vol 2, Iss 8, Pp 761-770 (2013)
Biology Open

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec1b248cd7a0095495651221e1d2e95Test
http://bio.biologists.org/content/2/8/761Test

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