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المؤلفون: Zulkefeli Mohd, Albena T. Dinkova-Kostova, Madhu Katyayani Balijepalli, Mallikarjuna Rao Pichika, Kit-Kay Mak, Zhang Shiming, Ola Epemolu
المصدر: Phytomedicine Plus, Vol 1, Iss 1, Pp 100018-(2021)
مصطلحات موضوعية: Swietenine, Chemistry, medicine.drug_class, Mechanism (biology), General Engineering, Inflammation, Pharmacology, Anti-inflammatory, In vitro, NRF2, Other systems of medicine, Swietenia macrophylla, medicine, Microsome, General Earth and Planetary Sciences, NQO1, Metabolic stability, medicine.symptom, Tetranortriterpenoid, RZ201-999, General Environmental Science
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fcb039eae28402ac69effc2f33675cTest
http://www.sciencedirect.com/science/article/pii/S266703132030018XTest -
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المؤلفون: Eduardo Muñoz, Albena T. Dinkova-Kostova, María E. Prados, Giovanni Apendino, Laura Casares, Juan D. Unciti-Broceta, Maureen Higgins, Laureano de la Vega, Diego Caprioglio, Daiana Mattoteia
المصدر: Redox Biology
Redox Biology, Vol 37, Iss, Pp 101689-(2020)مصطلحات موضوعية: Antioxidant, NF-E2-Related Factor 2, medicine.medical_treatment, Short Communication, Clinical Biochemistry, Inflammation, Pharmacology, medicine.disease_cause, Biochemistry, Neuroprotection, environment and public health, digestive system, Antioxidants, Cannabidiol derivative/ NRF2/ BACH1/ HMOX1/ neurodegenerative diseases, Cell Line, Mice, In vivo, medicine, Animals, lcsh:QH301-705.5, lcsh:R5-920, Chemistry, Multiple sclerosis, Organic Chemistry, Nrf2 activators, Neurodegenerative Diseases, respiratory system, medicine.disease, Disease Models, Animal, Oxidative Stress, Basic-Leucine Zipper Transcription Factors, lcsh:Biology (General), medicine.symptom, lcsh:Medicine (General), Cannabidiol, Oxidative stress, medicine.drug
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de4a453fd64e589b62478d05efde73bTest
https://pubmed.ncbi.nlm.nih.gov/32863231Test -
3KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease
المؤلفون: Sharadha Dayalan Naidu, Albena T. Dinkova-Kostova
المصدر: Open Biology
Open Biology, Vol 10, Iss 6 (2020)مصطلحات موضوعية: Models, Molecular, Proteasome Endopeptidase Complex, antioxidant, NF-E2-Related Factor 2, Immunology, Inflammation, Review, Review Article, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, NRF2, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, medicine, Humans, Molecular Targeted Therapy, lcsh:QH301-705.5, cysteine, Transcription factor, anti-inflammatory, 030304 developmental biology, Clinical Trials as Topic, 0303 health sciences, Kelch-Like ECH-Associated Protein 1, biology, General Neuroscience, Ubiquitination, respiratory system, KEAP1, Cytoprotection, Cell biology, Ubiquitin ligase, lcsh:Biology (General), redox, 030220 oncology & carcinogenesis, Chronic Disease, biology.protein, medicine.symptom, Cullin, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7017809c3d739b04628aa127f1f19a38Test
https://doi.org/10.1098/rsob.200105Test -
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المؤلفون: Jennifer E. Gallagher, Dorothy Kisielewski, John F. Dillon, Shaun V. Walsh, Diane Cassidy, David J. Harrison, Ritu Sharma, Tadashi Honda, John D. Hayes, Alison D. McNeilly, Michael L.J. Ashford, Albena T. Dinkova-Kostova, Rory J. McCrimmon
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 367-398 (2018)مصطلحات موضوعية: NQO1, NAD(P)H:quinone oxidoreductase 1, TNF-α, tumor necrosis factor-α, IRE1α, inositol requiring kinase-1α, SCAD, short-chain acyl-CoA dehydrogenase, C/EBP, CCAAT/enhancer-binding protein, PCR, polymerase chain reaction, UPR, unfolded protein response, 0302 clinical medicine, Fibrosis, MGPAT, mitochondrial glycerol-3-phosphate acetyltransferase, ATF4, activating transcription factor-4, DGAT2, diacylglycerol acyltransferase-2, LXRα, liver X receptor α, Glucose homeostasis, eIf2α, eukaryotic translation initiation factor 2A, IKK, IκB kinase, ACOT7, acetyl-CoA thioesterase 7, Original Research, TGFβ, transforming growth factor beta-1, SLC7A11, solute carrier family 7 member 11, GSSG, oxidized glutathione, MTTP, microsomal triglyceride transfer protein, NASH, Gastroenterology, TXN1, thioredoxin-1, 3. Good health, ChREBP, carbohydrate-responsive element-binding protein, 030220 oncology & carcinogenesis, NASH, nonalcoholic steatohepatitis, medicine.medical_specialty, PARP, poly ADP ribose polymerase, qRT-PCR, quantitative reverse transcriptase PCR, GSTM1, glutathione S-transferase Mu-1, GCLC, glutamate-cysteine ligase catalytic, Nrf2, ACACA, acetyl-CoA carboxylase alpha, 03 medical and health sciences, FXR, farnesoid X receptor, Nrf2, NF-E2 p45-related factor 2, COX2, cyclooxygenase-2, Keap1, Kelch-like ECH-associated protein-1, PPARα, peroxisome proliferator-activated receptor α, PTT, pyruvate tolerance test, HMOX1, heme oxygenase-1, RC, regular chow, p58IPK, p58 inhibitor of the PKR kinase, medicine.disease, TBE-31, 030104 developmental biology, Endocrinology, COL1A1, collagen, type I, alpha-1, Unfolded protein response, CAT, catalase, 0301 basic medicine, PDI, protein disulfide isomerase, GSH, reduced glutathione, FASN, fatty acid synthase, BCL-2, B-cell lymphoma, MPO, myeloperoxidase, AP-1, activator protein 1, DMSO, dimethyl sulfoxide, medicine.disease_cause, SHP, small heterodimer partner, CDDO, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid, CHOP, C/EBP homologous protein, TXNRD1, thioredoxin reductase-1, HF30Fr, high-fat diet with 30% fructose in drinking water, IκB, inhibitor of NF-κB, SFN, sulforaphane, ADRP, adipose differentiation-related protein, NAS, NAFLD activity score, GPX2, glutathione peroxidase-2, Chemistry, MCP-1, monocyte chemotactic protein-1, XBP1, X-box binding protein-1, SREBP-1c, sterol regulatory element-binding protein-1c, Lipogenesis, GTT, glucose tolerance test, PERK, PRK-like endoplasmic reticulum kinase, PTGR1, prostaglandin reductase-1, GSTA4, glutathione S-transferase Alpha-4, medicine.symptom, NAFLD, non-alcoholic fatty liver disease, α-SMA, alpha smooth muscle actin, ACOX2, acetyl-CoA oxidase 2, HFFr, high-fat diet with fructose in drinking water, NF-κB, nuclear factor-κB, GCLM, glutamate-cysteine ligase modifier, Inflammation, JNK1, c-Jun N-terminal kinase 1, CD36, cluster of differentiation 36, ER, endoplasmic reticulum, Insulin resistance, HF, high-fat, HF55Fr, high-fat diet with 55% fructose in drinking water, Internal medicine, ATF6, activating transcription factor-6, medicine, ApoB, apolipoprotein B, lcsh:RC799-869, CES1G, carboxylesterase 1g, ITT, insulin tolerance test, MCD, methionine- and choline-deficient, ACLY, ATP citrate lyase, Hepatology, SCD1, stearoyl-CoA desaturase-1, NOS2, nitric oxide synthase-2, PRDX6, peroxiredoxin 6, PPARγ, peroxisome proliferator-activated receptor γ, BIP, binding immunoglobulin protein, H&E, hematoxylin and eosin, lcsh:Diseases of the digestive system. Gastroenterology, Steatosis, CPT1A, carnitine palmitoyltransferase 1a, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdd8de56b5ba950a8c970d72cce7012Test
https://doi.org/10.1016/j.jcmgh.2017.11.016Test -
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المؤلفون: Luke A. J. O'Neill, Dave Speijer, Esther Lutgens, Michel van Weeghel, Annette E. Neele, Koen H.M. Prange, Saskia van der Velden, Albena T. Dinkova-Kostova, Menno P.J. de Winther, Rob C. I. Wüst, Jeroen Baardman, Maarten E. Witte, Simone Denis, Jan Van den Bossche, Elena V. Knatko, Dylan G. Ryan, Sanne G.S. Verberk, Riekelt H. Houtkooper
المساهمون: Molecular cell biology and Immunology, Physiology, Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Atherosclerosis & ischemic syndromes, Graduate School, Medical Biochemistry, AII - Inflammatory diseases, Laboratory Genetic Metabolic Diseases, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, AMS - Ageing & Morbidty, ACS - Amsterdam Cardiovascular Sciences, AII - Amsterdam institute for Infection and Immunity, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Aging & Later Life, AGEM - Endocrinology, metabolism and nutrition, AGEM - Inborn errors of metabolism, ARD - Amsterdam Reproduction and Development
المصدر: Cell Reports, 25(8), 2044-2052.e5. Cell Press
Baardman, J, Verberk, S G S, Prange, K H M, van Weeghel, M, van der Velden, S, Ryan, D G, Wüst, R C I, Neele, A E, Speijer, D, Denis, S W, Witte, M E, Houtkooper, R H, O'neill, L A, Knatko, E V, Dinkova-Kostova, A T, Lutgens, E, de Winther, M P J & Van den Bossche, J 2018, ' A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia ', Cell Reports, vol. 25, no. 8, pp. 2044-2052.e5 . https://doi.org/10.1016/j.celrep.2018.10.092Test, https://doi.org/10.1016/j.celrep.2018.10.092Test
Cell reports, 25(8), 2044-2052. Cell Press
Cell Reports, Vol 25, Iss 8, Pp 2044-2052.e5 (2018)
Baardman, J, Verberk, S G S, Prange, K H M, van Weeghel, M, van der Velden, S, Ryan, D G, Wüst, R C I, Neele, A E, Speijer, D, Denis, S W, Witte, M E, Houtkooper, R H, O'neill, L A, Knatko, E V, Dinkova-Kostova, A T, Lutgens, E, de Winther, M P J & Van den Bossche, J 2018, ' A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia ', Cell Reports, vol. 25, no. 8, pp. 2044-2052.e5 . https://doi.org/10.1016/j.celrep.2018.10.092Testمصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Male, NF-E2-Related Factor 2, Citric Acid Cycle, immunometabolism, pentose phosphate pathway, Inflammation, Pentose phosphate pathway, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Nrf2, 03 medical and health sciences, 0302 clinical medicine, Immune system, SDG 3 - Good Health and Well-being, cardiovascular disease, medicine, Macrophage, Animals, lcsh:QH301-705.5, hypercholesterolemia, Chemistry, meta-inflammation, Metabolism, metabolic disease, foam cells, Cell biology, macrophages, Mice, Inbred C57BL, 030104 developmental biology, Cell metabolism, lcsh:Biology (General), inflammation, 030220 oncology & carcinogenesis, Cytokine secretion, Female, medicine.symptom, atherosclerosis, Glycolysis, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ef415f4ba7df2f11e9a8a4f10fe79fTest
https://research.vumc.nl/en/publications/18d3e0ec-b7da-4ccb-bcdd-e585bd6780daTest -
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المؤلفون: Masayuki Yamamoto, Ying Zhang, Albena T. Dinkova-Kostova, Elena V. Knatko, Sukirti Kalra, Tadashi Honda
المصدر: Cancer Prevention Research. 5:973-981
مصطلحات موضوعية: Cancer Research, NF-E2-Related Factor 2, Ultraviolet Rays, Administration, Topical, Metabolite, Inflammation, Azathioprine, Pharmacology, medicine.disease_cause, Mice, chemistry.chemical_compound, medicine, Animals, Thioguanine, Transcription factor, Cells, Cultured, Adaptor Proteins, Signal Transducing, Skin, Mice, Knockout, Mice, Hairless, Kelch-Like ECH-Associated Protein 1, Fibroblasts, Phenanthrenes, Embryo, Mammalian, KEAP1, Skin patch, Mice, Inbred C57BL, Cytoskeletal Proteins, Oxidative Stress, Liver, Oncology, chemistry, Biochemistry, Cytoprotection, Female, medicine.symptom, Reactive Oxygen Species, Oxidative stress, DNA, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cbe1c3fbac2971082bc35cf6b05bbaTest
https://doi.org/10.1158/1940-6207.capr-12-0041Test -
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المؤلفون: Michael L.J. Ashford, Rory J. McCrimmon, Jennifer E. Gallagher, Alison D. McNeilly, Albena T. Dinkova-Kostova, John D. Hayes, John Sharkey
المصدر: Diabetes. 65(10)
مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, endocrine system diseases, NF-E2-Related Factor 2, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Recurrent hypoglycemia, Inflammation, Hypoglycemia, medicine.disease_cause, Neuroprotection, Hippocampus, Polymerase Chain Reaction, 03 medical and health sciences, Mice, Random Allocation, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Animals, Cognitive Dysfunction, Cell damage, Mice, Knockout, business.industry, Insulin, nutritional and metabolic diseases, medicine.disease, Mice, Inbred C57BL, Oxidative Stress, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 1, Lipid Peroxidation, medicine.symptom, business, 030217 neurology & neurosurgery, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ad0e39c1885a3af71b001695b4dab88Test
https://pubmed.ncbi.nlm.nih.gov/27411381Test -
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المؤلفون: Paul Talalay, Hua Liu, Albena T. Dinkova-Kostova
المصدر: Proceedings of the National Academy of Sciences. 105:15926-15931
مصطلحات موضوعية: NF-E2-Related Factor 2, medicine.medical_treatment, Repressor, Inflammation, Protective Agents, Benzylidene Compounds, Arsenicals, Gene Expression Regulation, Enzymologic, Hazardous Substances, Proinflammatory cytokine, Mice, Isothiocyanates, Metals, Heavy, medicine, Animals, Inducer, Adaptor Proteins, Signal Transducing, Kelch-Like ECH-Associated Protein 1, Multidisciplinary, Chemistry, Acute-phase protein, Biological Sciences, Oxidants, KEAP1, Cytoskeletal Proteins, Cytokine, Biochemistry, Macrophages, Peritoneal, medicine.symptom, Biomarkers, Acute-Phase Proteins, Toluene, Cysteine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57037a5e554d1582fb48d1fd95407421Test
https://doi.org/10.1073/pnas.0808346105Test -
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المؤلفون: Albena T. Dinkova-Kostova, Renee Risingsong, Nanjoo Suh, Michael B. Sporn, Paul Talalay, Katherine K. Stephenson, Charlotte R. Williams, Darlene B. Royce, Tadashi Honda, Karen T. Liby, Gordon W. Gribble, Chitra Sundararajan
المصدر: Molecular Cancer Therapeutics. 6:2113-2119
مصطلحات موضوعية: Male, Cancer Research, Apoptosis, Pharmacology, Nitric Oxide, Mice, chemistry.chemical_compound, Cell Line, Tumor, Betulinic acid, NAD(P)H Dehydrogenase (Quinone), Animals, Humans, Potency, Betulinic Acid, Cell Proliferation, bcl-2-Associated X Protein, Inflammation, chemistry.chemical_classification, biology, Chemistry, Macrophages, Fibroblasts, Antineoplastic Agents, Phytogenic, Triterpenes, In vitro, Nitric oxide synthase, Enzyme, Oncology, Biochemistry, Cytoprotection, Cell culture, Cancer cell, biology.protein, Pentacyclic Triterpenes
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af07d37feaa0f1ccb23a3658e072dc3Test
https://doi.org/10.1158/1535-7163.mct-07-0180Test -
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المؤلفون: Gordon W. Gribble, Karen T. Liby, Xiangqun Gao, Paul Talalay, Renee Risingsong, Nanjoo Suh, W. David Holtzclaw, Katherine K. Stephenson, Charlotte R. Williams, Albena T. Dinkova-Kostova, Michael B. Sporn, Tadashi Honda
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 102(12)
مصطلحات موضوعية: NF-E2-Related Factor 2, Nitric Oxide Synthase Type II, Binding, Competitive, Cell Line, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Oxidoreductase, NAD(P)H Dehydrogenase (Quinone), Animals, Humans, RNA, Messenger, Enzyme inducer, Enzyme Inhibitors, Oleanolic acid, Adaptor Proteins, Signal Transducing, chemistry.chemical_classification, Inflammation, Multidisciplinary, Kelch-Like ECH-Associated Protein 1, biology, U937 cell, Terpenes, NADPH Dehydrogenase, U937 Cells, Biological Sciences, KEAP1, Heme oxygenase, Nitric oxide synthase, DNA-Binding Proteins, Cytoskeletal Proteins, Oxidative Stress, chemistry, Biochemistry, Enzyme Induction, biology.protein, Trans-Activators, NAD+ kinase, Nitric Oxide Synthase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80aa335503961ad33e5b09d4ab87604fTest
https://pubmed.ncbi.nlm.nih.gov/15767573Test