دورية أكاديمية
Balamuthia mandrillaris Encephalitis Presenting as a Symptomatic Focal Hypodensity in an Immunocompromised Patient
| العنوان: | Balamuthia mandrillaris Encephalitis Presenting as a Symptomatic Focal Hypodensity in an Immunocompromised Patient |
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| المؤلفون: | Sakusic, Amra, Chen, Baibing, McPhearson, Kimberly, Badi, Mohammed, Freeman, William D, Huang, Josephine F, Siegel, Jason L, Jentoft, Mark E, Oring, Justin M, Verdecia, Jorge, Meschia, James F |
| المصدر: | Open Forum Infectious Diseases ; volume 10, issue 3 ; ISSN 2328-8957 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Infectious Diseases, Oncology |
| الوصف: | We present the case of a 61-year-old woman with a history of orthotopic heart transplant who was hospitalized with new-onset headache. Magnetic resonance imaging (MRI) of the brain revealed T2 hyperintense signal involving the left occipital lobe with leptomeningeal enhancement and mild vasogenic edema. Initial neurologic examination was normal; however, after 7 days she developed imbalance, visual disturbances, night sweats, bradyphrenia, alexia without agraphia, and right hemianopsia. Brain MRI showed enlargement of the left occipital mass and worsening edema. Stereotactic needle biopsy showed nondiagnostic necrosis. The patient continued to deteriorate despite dexamethasone. Cerebrospinal fluid (CSF) suggested infection, and cytomegalovirus CSF polymerase chain reaction (PCR) was positive. The patient received vancomycin, imipenem, and ganciclovir. After obtaining a positive serum beta-D-glucan (Fungitell), amphotericin was added. Despite best medical efforts, the patient died. Postmortem broad-range PCR sequencing of the brain tissue was positive for rare amoeba Balamuthia mandrillaris. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ofid/ofad094 |
| DOI: | 10.1093/ofid/ofad094/49282267/ofad094.pdf |
| الإتاحة: | https://doi.org/10.1093/ofid/ofad094Test https://academic.oup.com/ofid/article-pdf/10/3/ofad094/49684407/ofad094.pdfTest |
| حقوق: | https://creativecommons.org/licenses/by-nc-nd/4.0Test/ |
| رقم الانضمام: | edsbas.60654F3F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ofid/ofad094 |
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