دورية أكاديمية
Sarcoid-like Granulomatosis Associated with Immune Checkpoint Inhibitors in Melanoma
| العنوان: | Sarcoid-like Granulomatosis Associated with Immune Checkpoint Inhibitors in Melanoma |
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| المؤلفون: | Audrey Melin, Émilie Routier, Séverine Roy, Pauline Pradere, Jerome Le Pavec, Thibaut Pierre, Noémie Chanson, Jean-Yves Scoazec, Olivier Lambotte, Caroline Robert |
| المصدر: | Cancers, Vol 14, Iss 2937, p 2937 (2022) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | melanoma, immunotherapy, immune checkpoint inhibitor, granulomatosis, sarcoidosis, mTOR, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | We aimed to review the clinical and biological presentation of granulomatosis associated with immune-checkpoint inhibitors (ICI) in patients with melanoma and to explore its association with classical sarcoidosis as well as with cancer response to ICI. To this end, a retrospective study on 18 melanoma patients with histologically proven ICI-induced granulomatosis over a 12-year period in a single center, as well as on 67 similar cases reported in the literature, was conducted. Results indicate ICI-induced granulomatosis is an early side effect (median time to onset: 2 months). Its clinical presentation, with predominant (90%) thoracic involvement, histopathological appearance and supposed underlying biology (involving the mTOR pathway in immune cells, Th17 polarization and TReg dysfunction) are indistinguishable from those of sarcoidosis. Moreover, it appears to be associated with ICI benefit (>65% objective response rate). Evolution is generally favorable, and symptomatic steroid treatment and/or ICI discontinuation are rarely necessary. ICI-associated granulomatosis is critical to explore for several reasons. Practically, it is essential to differentiate it from cancer progression. Secondly, this “experimental” sarcoidosis brings new elements that may help to address sarcoidosis origin and pathophysiology. Its association with ICI efficacy must be confirmed on a larger scale but could have significant impacts on patient management and biomarker definition. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2072-6694 |
| العلاقة: | https://www.mdpi.com/2072-6694/14/12/2937Test; https://doaj.org/toc/2072-6694Test; https://doaj.org/article/8a1b94412b7948d5a6e59ed6e0b193e0Test |
| DOI: | 10.3390/cancers14122937 |
| الإتاحة: | https://doi.org/10.3390/cancers14122937Test https://doaj.org/article/8a1b94412b7948d5a6e59ed6e0b193e0Test |
| رقم الانضمام: | edsbas.75FD3E40 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726694 |
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| DOI: | 10.3390/cancers14122937 |