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المؤلفون: Bärbel Rohrer, Bryan W. Jones, Elisabeth Obert, Crystal Nicholson, Nathaniel Parsons, Balasubramaniam Annamalai
المصدر: Investigative Ophthalmology & Visual Science
مصطلحات موضوعية: 0301 basic medicine, genetic structures, chemical and pharmacologic phenomena, Retinal Pigment Epithelium, medicine.disease_cause, Retinal ganglion, choroidal neovascularization, Retina, Viral vector, 03 medical and health sciences, Macular Degeneration, Mice, 0302 clinical medicine, smoke-induced ocular pathology, medicine, Animals, Adeno-associated virus, Complement Activation, complement system, alternative pathway inhibitor, natural antibody-mediated targeting, Retinal pigment epithelium, business.industry, Choroid, Macular degeneration, medicine.disease, eye diseases, Complement system, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Complement Inactivating Agents, Intravitreal Injections, 030221 ophthalmology & optometry, Cancer research, Alternative complement pathway, sense organs, business, encapsulated ARPE-19 cells, Tomography, Optical Coherence
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f447dad3a63b424f9e4c1faccf313831Test
http://europepmc.org/articles/PMC8039473Test -
2
المصدر: Molecular Vision
مصطلحات موضوعية: genetic structures, Biological Availability, Gene Expression, Technical Brief, chemical and pharmacologic phenomena, Capsules, Cell Line, Mice, Protein Domains, Animals, Humans, Cell Encapsulation, Immunohistochemistry, eye diseases, Choroidal Neovascularization, Recombinant Proteins, Mice, Inbred C57BL, Drug Combinations, Complement Inactivating Agents, Microscopy, Fluorescence, Complement Factor H, Proteoglycans, Receptors, Complement 3d, sense organs, Collagen, Laminin, Tomography, Optical Coherence
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::b211f78c19b55f13182efa6ba7dbeda7Test
https://pubmed.ncbi.nlm.nih.gov/32476817Test -
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المؤلفون: Elisabeth Obert, Cecile Nasarre, Bärbel Rohrer, Gloriane Schnabolk, Balasubramaniam Annamalai, Stephen Tomlinson, Nathaniel Parsons, Alfred S. Lewin
المصدر: Molecular Therapy: Methods & Clinical Development, Vol 9, Iss, Pp 1-11 (2018)
Molecular Therapy. Methods & Clinical Developmentمصطلحات موضوعية: 0301 basic medicine, lcsh:QH426-470, genetic structures, Complement receptor 2, retinal pigment epithelium, chemical and pharmacologic phenomena, Gene delivery, choroidal neovascularization, Article, 03 medical and health sciences, Genetics, Medicine, lcsh:QH573-671, age-related macular degeneration, Molecular Biology, Retinal pigment epithelium, lcsh:Cytology, business.industry, complement factor H, AAV, Macular degeneration, medicine.disease, eye diseases, 3. Good health, Complement system, lcsh:Genetics, 030104 developmental biology, Choroidal neovascularization, medicine.anatomical_structure, Factor H, Alternative complement pathway, Cancer research, Molecular Medicine, sense organs, medicine.symptom, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1359b940954672c2132c23dd77cff65Test
https://doi.org/10.1016/j.omtm.2017.11.003Test -
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المؤلفون: Elisabeth Obert, Yujing Dang, Bärbel Rohrer, Xiaofeng Zuo, Manas R. Biswal, Ben Fogelgren, Yanhui Su, Glenn P. Lobo, Joshua H. Lipschutz, Altaf A. Kondkar
المصدر: International Journal of Molecular Sciences
Volume 22
Issue 10
International Journal of Molecular Sciences, Vol 22, Iss 5083, p 5083 (2021)مصطلحات موضوعية: 0301 basic medicine, genetic structures, Vesicular Transport Proteins, exocyst complex component 5, Degeneration (medical), Retinal Pigment Epithelium, Photoreceptor cell, Mice, chemistry.chemical_compound, 0302 clinical medicine, Biology (General), Receptor, Zebrafish, Spectroscopy, Mice, Knockout, Retinal Degeneration, General Medicine, Computer Science Applications, Cell biology, Chemistry, medicine.anatomical_structure, Visual function, QH301-705.5, Vision Disorders, Exocyst, Biology, Article, Catalysis, Visual photoreceptor, Inorganic Chemistry, 03 medical and health sciences, visual function, medicine, Animals, biochemistry, Photoreceptor Cells, Physical and Theoretical Chemistry, QD1-999, Molecular Biology, Retinal thinning, Retinal pigment epithelium, retinal pigmented epithelium, Organic Chemistry, Retinal, biology.organism_classification, photoreceptor, eye diseases, Mice, Inbred C57BL, 030104 developmental biology, RPE65, chemistry, sense organs, 030217 neurology & neurosurgery
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8c642933bbf9d30deb02b480c1d2e0Test
https://doi.org/10.3390/ijms22105083Test -
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المؤلفون: Bärbel Rohrer, Elisabeth Obert, Gloriane Schnabolk, Nirmal K. Banda
المصدر: Investigative Ophthalmology & Visual Science
مصطلحات موضوعية: rheumatoid arthritis, Male, musculoskeletal diseases, 0301 basic medicine, Retinal degeneration, Pathology, medicine.medical_specialty, genetic structures, Arthritis, Retinal Pigment Epithelium, Systemic inflammation, choroidal neovascularization, Polymerase Chain Reaction, Retina, Lesion, Macular Degeneration, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Animals, age-related macular degeneration, Inflammation, optical coherence tomography, Retinal pigment epithelium, business.industry, Retinal, Macular degeneration, medicine.disease, Arthritis, Experimental, eye diseases, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Choroidal neovascularization, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Female, sense organs, medicine.symptom, business, Tomography, Optical Coherence
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cba8522077d87ffe4fbbabc1b765d74eTest
https://doi.org/10.1167/iovs.61.14.11Test -
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المؤلفون: Gloriane Schnabolk, Bärbel Rohrer, Kit N. Simpson
المصدر: Investigative Ophthalmology & Visual Science
مصطلحات موضوعية: rheumatoid arthritis, Male, medicine.medical_specialty, Databases, Factual, genetic structures, Arthritis, Medicare, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, International Classification of Diseases, Geographic Atrophy, Surveys and Questionnaires, Internal medicine, wet AMD, medicine, Humans, age-related macular degeneration, Survival analysis, Aged, Retrospective Studies, Aged, 80 and over, 030203 arthritis & rheumatology, business.industry, Clinical and Epidemiologic Research, MarketScan, Retrospective cohort study, Exudates and Transudates, Odds ratio, medicine.disease, Survival Analysis, United States, eye diseases, Confidence interval, 3. Good health, Antirheumatic Agents, Rheumatoid arthritis, 030221 ophthalmology & optometry, dry AMD, Female, Diagnosis code, business, Follow-Up Studies, Cohort study
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc55a6b9ba7461091a600a864083dd9aTest
https://doi.org/10.1167/iovs.18-26444Test -
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المؤلفون: Marwa Belhaj, Balasubramaniam Annamalai, Carlene Brandon, Nathaniel Parsons, Bärbel Rohrer, Jay D. Potts
المصدر: Translational Vision Science & Technology
مصطلحات موضوعية: 0301 basic medicine, genetic structures, Biomedical Engineering, chemical and pharmacologic phenomena, Pharmacology, choroidal neovascularization, 03 medical and health sciences, Complement inhibitor, medicine, complement system, Retina, Chemistry, Articles, Macular degeneration, medicine.disease, Fusion protein, eye diseases, 3. Good health, Complement system, targeted alternative pathway inhibitor CR2-fH, Ophthalmology, 030104 developmental biology, Choroidal neovascularization, medicine.anatomical_structure, Alternative complement pathway, Immunohistochemistry, sense organs, medicine.symptom, encapsulated ARPE-19 cells
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5ef0642704c74f7b0b440dea44b690Test
https://pubmed.ncbi.nlm.nih.gov/29576927Test -
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المؤلفون: Bushra Rahman, Elisabeth Obert, Glenn P. Lobo, Bärbel Rohrer, Yi Shi
المصدر: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)مصطلحات موضوعية: 0301 basic medicine, genetic structures, Retinol transport, lcsh:Medicine, Photoreceptor cell, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Photoreceptor cell maintenance, medicine, Morphogenesis, Animals, lcsh:Science, Zebrafish, Vision, Ocular, Retina, Multidisciplinary, biology, lcsh:R, Retinol, Gene Expression Regulation, Developmental, Membrane Transport Proteins, Anatomy, Zebrafish Proteins, biology.organism_classification, Retinal Photoreceptor Cell Outer Segment, Photoreceptor outer segment, eye diseases, Cell biology, Retinol binding protein, 030104 developmental biology, medicine.anatomical_structure, Enterocytes, chemistry, Hepatocytes, lcsh:Q, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e50e5cec73c66029b49636d8b485511Test
https://pubmed.ncbi.nlm.nih.gov/29176573Test -
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المؤلفون: Krista Johnson, Himanshu Raikwar, Kevin J. Moore, Gloriane Schnabolk, Beth Coughlin, Kusumam Joseph, Bärbel Rohrer, Yi Wang, Kannan Kunchithapautham
المصدر: Scientific Reports
مصطلحات موضوعية: 0301 basic medicine, Pathology, medicine.medical_specialty, genetic structures, Gene Expression, Complement C5a, Retinal Pigment Epithelium, Adaptive Immunity, CD8-Positive T-Lymphocytes, Light Coagulation, Biology, Article, Cell Line, Pathogenesis, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Cell Movement, Splenocyte, medicine, Animals, Humans, Receptor, Anaphylatoxin C5a, Multidisciplinary, Choroid, Interleukin-17, Receptors, Antigen, T-Cell, gamma-delta, Macular degeneration, medicine.disease, Acquired immune system, Antibodies, Neutralizing, Choroidal Neovascularization, Immunity, Innate, eye diseases, 3. Good health, Complement system, Mice, Inbred C57BL, 030104 developmental biology, Choroidal neovascularization, Injections, Intravenous, Immunology, 030221 ophthalmology & optometry, Systemic administration, Th17 Cells, sense organs, medicine.symptom, Spleen
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29147664889c8b9def6af4cb82e1c385Test
https://doi.org/10.1038/srep23794Test -
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المؤلفون: V. Michael Holers, Beth Coughlin, Steffen Thiel, Kannan Kunchithapautham, Liudmila Kulik, Bärbel Rohrer, Nicole M. Thielens, Mausumi Bandyopadhyay, Kusumam Joseph
المساهمون: Institut de biologie structurale (IBS - UMR 5075 ), Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Thomas, Frank, Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
المصدر: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2013, 288 (18), pp.12753-65
Joseph, K, Kulik, L, Coughlin, B, Kunchithapautham, K, Bandyopadhyay, M, Thiel, S, Thielens, N M, Holers, V M & Rohrer, B 2013, ' Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner ', Journal of Biological Chemistry, vol. 288, no. 18, pp. 12753-65 . https://doi.org/10.1074/jbc.M112.421891Test
Journal of Biological Chemistry, 2013, 288 (18), pp.12753-65مصطلحات موضوعية: MESH: Complement Pathway, Mannose-Binding Lectin, MESH: Complement C1q, genetic structures, Complement Pathway, Alternative, Retinal Pigment Epithelium, Biochemistry, MESH: Mice, Knockout, Mice, 0302 clinical medicine, MESH: Oxidants, MESH: Animals, Complement C1q, Phospholipids, Mannan-binding lectin, Mice, Knockout, 0303 health sciences, MESH: Oxidative Stress, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Oxidants, MESH: Immunoglobulin M, MESH: Retinal Pigment Epithelium, 3. Good health, Cell biology, Lectin pathway, Factor H, MESH: Hydrogen Peroxide, Ficolin, [SDV.BBM.BS] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], Immunology, Biology, Cell Line, 03 medical and health sciences, MESH: Homeodomain Proteins, Animals, Humans, Molecular Biology, MESH: Mice, 030304 developmental biology, Homeodomain Proteins, MESH: Phospholipids, MESH: Humans, Complement Pathway, Mannose-Binding Lectin, Cell Biology, Hydrogen Peroxide, eye diseases, Complement system, MESH: Cell Line, Oxidative Stress, Immunoglobulin M, 030221 ophthalmology & optometry, Alternative complement pathway, sense organs, Complement membrane attack complex, MESH: Complement Pathway, Alternative
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac7a4b3de08eedf1fcfd9d4711a76f1Test
https://hal.univ-grenoble-alpes.fr/hal-01322432Test