نتائج البحث - "Histone Acetyltransferases"

المصدر: PLoS Genetics
PLoS Genetics, Vol 16, Iss 5, p e1008770 (2020)
Præstholm, S M, Siersbæk, M S, Nielsen, R, Zhu, X, Hollenberg, A N, Cheng, S-Y & Grøntved, L 2020, ' Multiple mechanisms regulate H3 acetylation of enhancers in response to thyroid hormone ', PLOS Genetics, vol. 16, no. 5, e1008770 . https://doi.org/10.1371/journal.pgen.1008770Test

مصطلحات موضوعية: Male, Cancer Research, Gene Expression, QH426-470, Biochemistry, Histones, Mice, 0302 clinical medicine, Transcription (biology), Post-Translational Modification, Receptor, Genetics (clinical), Nuclear receptor co-repressor 1, Histone Acetyltransferases, Regulation of gene expression, 0303 health sciences, Receptors, Thyroid Hormone, Mammalian Genomics, Chemistry, Chromosome Biology, Chromatin Modification, Chemical Reactions, Acetylation, Histone Modification, Animal Models, Genomics, Chromatin, Cell biology, Histone, Enhancer Elements, Genetic, Liver, Experimental Organism Systems, Physical Sciences, Epigenetics, Research Article, Thyroid Hormones, Histone Acetylation, Mouse Models, Biology, Research and Analysis Methods, Histone Deacetylases, 03 medical and health sciences, Model Organisms, DNA-binding proteins, Genetics, Animals, Nuclear Receptor Co-Repressor 1, Gene Regulation, Enhancer, Molecular Biology, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, Thyroid hormone receptor, Biology and life sciences, Proteins, Cell Biology, Hormones, Gene Expression Regulation, Animal Genomics, biology.protein, Animal Studies, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd81d267b38f828236f1d7df9844b675Test
https://pubmed.ncbi.nlm.nih.gov/32453730Test

6

A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum

المؤلفون: Xiaoying Liang, Amuza Byaruhanga Lucky, Swamy R. Adapa, Hui Min, Liwang Cui, Chengqi Wang, Kami Kim, Jun Miao, Rays H. Y. Jiang

المصدر: PLoS Pathogens, Vol 17, Iss 8, p e1009351 (2021)
PLoS Pathogens

مصطلحات موضوعية: Plasmodium, Erythrocytes, Euchromatin, Mutagenesis and Gene Deletion Techniques, Protozoan Proteins, Gene Expression, Biochemistry, Histones, Gene expression, Malaria, Falciparum, Biology (General), Histone Acetyltransferases, Protozoans, Regulation of gene expression, Virulence, biology, Chromosome Biology, Malarial Parasites, Eukaryota, Acetylation, Chromatin, Cell biology, SAGA complex, Histone, Epigenetics, Research Article, Histone acetyltransferase complex, QH301-705.5, DNA transcription, Plasmodium falciparum, Immunology, Research and Analysis Methods, Microbiology, Hypoxia-Inducible Factor-Proline Dioxygenases, Virology, Parasite Groups, DNA-binding proteins, Genetics, Gene family, Humans, Protein Interaction Domains and Motifs, Trophozoites, Molecular Biology Techniques, Molecular Biology, Transcription factor, Deletion Mutagenesis, Organisms, Biology and Life Sciences, Proteins, Cell Biology, Histone acetyltransferase, RC581-607, Parasitic Protozoans, Gene Expression Regulation, biology.protein, Parasitology, Immunologic diseases. Allergy, Apicomplexa

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36574bc3d939995ffe0e230f3664f72Test
https://doi.org/10.1371/journal.ppat.1009351Test

7

IRF5 is elevated in childhood-onset SLE and regulated by histone acetyltransferase and histone deacetylase inhibitors

المؤلفون: Jin Shu, Li-Li Zhuang, Jun Qian, Ling Li, Lan-Bo Zhou, Guo-Ping Zhou, Hai-Guo Yu, Rui Jin, Zhi-Dan Fan, Lu-Lu Wang

المصدر: Oncotarget

مصطلحات موضوعية: Male, 0301 basic medicine, Transcription, Genetic, Sp1 Transcription Factor, Gene Expression, Autoimmunity, p300, P300-CBP Transcription Factors, Cell Line, 03 medical and health sciences, systemic lupus erythematosus, HDAC inhibitors, Genes, Reporter, IRF5, Gene expression, medicine, Humans, Lupus Erythematosus, Systemic, p300-CBP Transcription Factors, Age of Onset, Child, Promoter Regions, Genetic, Autoantibodies, Histone Acetyltransferases, Regulation of gene expression, biology, Interleukin-6, Tumor Necrosis Factor-alpha, Histone acetyltransferase, Histone Deacetylase Inhibitors, 030104 developmental biology, Trichostatin A, Gene Expression Regulation, Oncology, Case-Control Studies, Child, Preschool, Interferon Regulatory Factors, Immunology, Cancer research, biology.protein, Female, Histone deacetylase, Chromatin immunoprecipitation, Protein Binding, Research Paper, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87f7361f0917479e5785295eba8a7c3Test
https://doi.org/10.18632/oncotarget.17586Test

8

The replicative lifespan‐extending deletion of SGF73 results in altered ribosomal gene expression in yeast

المؤلفون: Amanda G. Mason, Renee M. Garza, Lorraine Pillus, Mark A. McCormick, Bhumil Patel, Brian K. Kennedy, Albert R. La Spada

المصدر: Aging Cell
Aging cell, vol 16, iss 4

مصطلحات موضوعية: 0301 basic medicine, Aging, Mutant, Sequence Homology, yeast, Medical and Health Sciences, 0302 clinical medicine, Sgf73, Gene Expression Regulation, Fungal, Gene expression, genome‐wide occupancy, Promoter Regions, Genetic, Histone Acetyltransferases, Genetics, Acetylation, Biological Sciences, Amino Acid, Fungal, genome-wide occupancy, Spinocerebellar ataxia, Original Article, Cell Division, Protein Binding, Signal Transduction, Ribosomal Proteins, Saccharomyces cerevisiae Proteins, Saccharomyces cerevisiae, Biology, Promoter Regions, 03 medical and health sciences, longevity gene, Genetic, Ribosomal protein, mental disorders, medicine, Humans, Spinocerebellar Ataxias, Neurodegeneration, replicative lifespan, Gene, Ataxin-7, Binding Sites, Microbial Viability, Base Sequence, Sequence Homology, Amino Acid, Promoter, Molecular Sequence Annotation, Cell Biology, Original Articles, Ribosomal RNA, medicine.disease, 030104 developmental biology, Gene Expression Regulation, Trans-Activators, Trinucleotide repeat expansion, 030217 neurology & neurosurgery, Gene Deletion, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578c1100c4067a19065d45df0560266aTest
http://europepmc.org/articles/PMC5506417Test

9

Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors

المؤلفون: Morgane Bourmaud, Anda Huna, Ikrame Naciri, Marthe Laisné, Pierre-Antoine Defossez, Selene Di Carlo, Nikhil Gupta, David Bernard, Lucie Peduto, Laure Ferry, Olivier Kirsh, Nadine Martin

المساهمون: Centre épigénétique et destin cellulaire (EDC), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Biologie de l'Os et du Cartilage : Régulations et Ciblages Thérapeutiques (BIOSCAR (UMR_S_1132 / U1132)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Stroma, inflammation et réparation tissulaire - Stroma, Inflammation and Tissue Repair, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), National Institutes of Health [EpiCALC 2013 to P.A.D. and D.B.], Institut National du Cancer [PLBio15–013 to P.A.D. and D.B.], Labex ‘Who am I?’ [ANR-11-LABX-0071 under ANR-11-IDEX-005–02, to P.A.D.], European Research Council [ERC648428-PERIF to L.P.], Fondation ARC [4th-year PhD scholarship to I.N., Programme Labellisé PGA1/RF20180206807 to P.A.D.], Fondation pour la Recherche Médicale [postdoctoral fellowship to A.H.]. The open access publication charge for this paper has been waived by Oxford University Press - NAR Editorial Board members are entitled to one free paper per year in recognition of their work on behalf of the journal., The authors thanks the Genomics Platform of Institut Curie for Nanostring analysis. The Nanostring platform of Institut Curie was initiated with the support of French grants (LabEx and EquipEx): ANR-10-IDEX-0001–02 PSL, ANR-11-LBX-0044 and « INCa-DGOS- 4654 » SIRIC11–002. We thank Valérie Doye, Stéphanie Bolhy, and Philippe Girard at Institut Jacques Monod for help with the Incucyte. Concerning the lentiviral vector production, we acknowledge Christophe Huret and the Paris Diderot Vectorology Platform of Paris Diderot University, Sorbonne Paris Cité, CNRS UMR 7216, Paris, France. We acknowledge the kind help of Elisabeth Brambilla with some experiments that do not appear in the submitted version of the manuscript. For the gift of reagents we acknowledge the kind contribution of Katrin Chua, Philippe Chavrier, Annabelle Decottignies, Sébastien Jauliac and Michael Kracht. Finally, we thank the following colleagues for useful discussions: Jean-Marc Vanacker, Robert Dante, Nathalie Théret, Saadi Khochbin, Céline Prunier, Céline Vallot, Claire Rougeulle, Isabelle Bernard-Pierrot, Slimane Ait-si-ali, Jonathan Weitzman, Valérie Lallemand-Mezger, ANR-11-IDEX-0005,USPC,Université Sorbonne Paris Cité(2011), European Project: 648428,H2020,ERC-2014-CoG,PERIF(2015), Centre épigénétique et destin cellulaire (EDC (UMR_7216)), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Jacques Monod (IJM), Biologie du Développement et Reproduction (BDR), Institut National de la Recherche Agronomique (INRA), École pratique des hautes études (EPHE), Centre de Recherche en Cancérologie de Lyon (CRCL), Stroma, inflammation et réparation tissulaire, ATMEL [Rousset], Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), TOMASSO DEVERGE, Carina, Université Sorbonne Paris Cité - - USPC2011 - ANR-11-IDEX-0005 - IDEX - VALID, Perivascular cells at the crossroads of inflammation, regeneration and fibrosis - PERIF - - H20202015-11-01 - 2020-10-31 - 648428 - VALID

المصدر: Nucleic Acids Research
Nucleic Acids Research, 2019, 47 (7), pp.3407-3421. ⟨10.1093/nar/gkz080⟩
Nucleic Acids Research, Oxford University Press, 2019, 47 (7), pp.3407-3421. ⟨10.1093/nar/gkz080⟩

مصطلحات موضوعية: Transcription, Genetic, [SDV]Life Sciences [q-bio], ADAM12 Protein, Triple Negative Breast Neoplasms, Biology, Protein Serine-Threonine Kinases, Cell Line, Transforming Growth Factor beta1, 03 medical and health sciences, 0302 clinical medicine, RNA interference, Cell Line, Tumor, Neoplasms, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Gene expression, Genetics, Humans, Epigenetics, Gene, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Histone Acetyltransferases, Regulation of gene expression, 0303 health sciences, Gene regulation, Chromatin and Epigenetics, Chromatin, Cell biology, Gene Expression Regulation, Neoplastic, [SDV] Life Sciences [q-bio], Gene Expression Regulation, Organ Specificity, Cancer cell, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], RNA Interference, 030217 neurology & neurosurgery, Genetic screen, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1969fba2e1097dcbb76d300efc78ccTest
https://hal-pasteur.archives-ouvertes.fr/pasteur-02071691/documentTest

10

Deficiency of the Chromatin Regulator Brpf1 Causes Abnormal Brain Development

المؤلفون: Hong Zhao, Linya You, Morag Park, Nicholas Bertos, Edwin Wang, Jinfeng Zou, Xiang-Jiao Yang

المصدر: Journal of Biological Chemistry. 290:7114-7129

مصطلحات موضوعية: nervous system development, Lysine Acetyltransferases, epigenetic mechanisms, neurological disorders, brain development, acetyl transferase, Biochemistry, Corpus Callosum, Mice, gene mutation, transcription factor, Mice, Knockout, Genetics, Histone Acetyltransferases, Regulation of gene expression, transcription factor TBX5, Behavior, Animal, biology, histone acetylation, multiple genes, Brain, Gene Expression Regulation, Developmental, gene expression regulation, neurologic disease, Chromatin, chromatin regulator BRPF1, corpus callosum agenesis, DNA-Binding Proteins, transcription factor Lhx4, Histone, intellectual disability, Robo3 gene, transcription, Hox gene, Transcriptional Activation, chromosomes, MOZ protein, zinc finger protein, forebrain, Neurogenesis, animal experiment, MORF protein, transcription factor Foxa1, agenesis, histone acetyltransferase, brain cortex, forebrain development, in vivo study, HBO1 protein, lysine acetyltransferase 7, Otx1 gene, Animals, Gene Silencing, Epigenetics, gene, Molecular Biology, mouse, acetylation, Adaptor Proteins, Signal Transducing, amino acids, lysine acetyltransferase 6B, lysine acetyltransferase 6A, epigenetics, intellectual impairment, histone acetyltransferases, brain malformation, genetic transcription, Cell Biology, Histone acetyltransferase, Bromodomain, transcription factor Twist1, homeodomain protein, gene expression, biology.protein, Agenesis of Corpus Callosum, protein, Carrier Proteins, Gene Deletion, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37490c17cbee82312139ee612db9c857Test
https://doi.org/10.1074/jbc.m114.635250Test

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