Features predicting unresectability in hepatoblastoma
| العنوان: | Features predicting unresectability in hepatoblastoma |
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| المؤلفون: | Francesca Vallortigara, Patrizia Dall'Igna, Massimo Rugge, Umberto Cillo, Gian Luca De Salvo, Enrico Talenti, Giorgio Perilongo, Lucia Zancan, Lorenzo D'Antiga |
| المصدر: | Università degli Studi di Padova-IRIS |
| بيانات النشر: | Wiley, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Hepatoblastoma, Male, Cancer Research, medicine.medical_specialty, Liver tumor, Adolescent, CHILDREN, neoplasia, medicine.medical_treatment, Liver transplantation, medicine, Humans, Child, Vein, Survival rate, Retrospective Studies, business.industry, Liver Neoplasms, Infant, Cancer, Combination chemotherapy, Prognosis, medicine.disease, Combined Modality Therapy, Survival Analysis, Liver Transplantation, Surgery, Transplantation, Treatment Outcome, medicine.anatomical_structure, Oncology, Child, Preschool, Female, alpha-Fetoproteins, business, Follow-Up Studies |
| الوصف: | BACKGROUND. Approximately 20% of patients who have hepatoblastoma (HB) still have unresectable disease after preoperative chemotherapy (POC). In these circumstances, orthotopic liver transplantation (OLT) should be performed 1 month after POC. The authors sought to identify presenting features that would predict unresectability in patients with HB and to provide suggestions for early referral and listing for OLT. METHODS. Notes, radiology films, and histology from patients who were treated over the previous 20 years were reviewed. Unfeasible resection was defined by bilobar involvement, vascular extension, and metastatic disease after POC. Failed conservative treatment (FCT) was used to categorize patients who were not disease-free with their native liver � 1 year after surgery. RESULTS. Of 28 patients who were studied, 14 patients underwent resection, and 10 patients required OLT. Four patients did not undergo any type of surgery because of tumor progression. Overall, the 5-year survival rate was 76% (95% confidence interval, 54.8–89%). Predictors of FCT were multifocality (P 5 .006), a high pretreatment extent of tumor (PRETEXT) score (III or IV; P 5 .006), portal vein involvement (P 5 .02), hepatic vein involvement (P 5 .02), or vena cava involvement (P 5 .05). Patients who achieved a curative resection presented at a younger age (median, 0.7 years vs 4.2 years, P 5 .02). Patients who had multifocal lesions and those who had an a-fetoprotein (aFP) level |
| تدمد: | 1097-0142 0008-543X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aef1d414a8f779d1b0121f1c6df94375Test https://doi.org/10.1002/cncr.22876Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....aef1d414a8f779d1b0121f1c6df94375 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
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