دورية أكاديمية
Case report: Ponatinib as a bridge to CAR-T cells and subsequent maintenance in a patient with relapsed/refractory Philadelphia-like acute lymphoblastic leukemia
| العنوان: | Case report: Ponatinib as a bridge to CAR-T cells and subsequent maintenance in a patient with relapsed/refractory Philadelphia-like acute lymphoblastic leukemia |
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| المؤلفون: | Giglio F., Campodonico E., Lorentino F., Noviello M., Xue E., Greco R., Lazzari L., Bruno A., Lupo Stanghellini M. T., Carrabba M. G., La Starza R., Casucci M., Bonini C., Chiaretti S., Peccatori J., Foa R., Ciceri F. |
| المساهمون: | Giglio, F., Campodonico, E., Lorentino, F., Noviello, M., Xue, E., Greco, R., Lazzari, L., Bruno, A., Lupo Stanghellini, M. T., Carrabba, M. G., La Starza, R., Casucci, M., Bonini, C., Chiaretti, S., Peccatori, J., Foa, R., Ciceri, F. |
| بيانات النشر: | Frontiers Media S.A. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | bridge therapy, CAR-T, maintenance therapy, Philadelphia-like ALL, ponatinib |
| الوصف: | Philadelphia (Ph)-like acute lymphoblastic leukemia (ALL) constitutes a heterogeneous subset of ALL with a uniformly unfavorable prognosis. The identification of mutations amenable to treatment with tyrosine kinase-inhibitors (TKIs) represents a promising field of investigation. We report the case of a young patient affected by relapsed/refractory Ph-like ALL treated with chimeric antigen receptor T (CAR-T) cells after successful bridging with compassionate-use ponatinib and low-dose prednisone. We restarted low-dose ponatinib maintenance three months later. Twenty months later, measurable residual disease negativity and B-cell aplasia persist. To the best of our knowledge, this is the first case reporting the use of ponatinib in Ph-like ALL as a bridge to and maintenance after CAR-T cell therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/WOS:000919962600001; volume:12; journal:FRONTIERS IN ONCOLOGY; https://hdl.handle.net/20.500.11768/138397Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85147219001; https://www.frontiersin.org/articles/10.3389/fonc.2022.1100105/fullTest |
| DOI: | 10.3389/fonc.2022.1100105 |
| DOI: | 10.3389/fonc.2022.1100105/full |
| الإتاحة: | https://doi.org/20.500.11768/138397Test https://doi.org/10.3389/fonc.2022.1100105Test https://hdl.handle.net/20.500.11768/138397Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F45EDEBD |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fonc.2022.1100105 |
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