دورية أكاديمية
Ferroptosis and circular RNAs
| العنوان: | Ferroptosis and circular RNAs |
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| المؤلفون: | Asif Ahmad Bhat, Neelima Kukreti, Muhammad Afzal, Ahsas Goyal, Riya Thapa, Haider Ali, Moyad Shahwan, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta |
| المصدر: | EXCLI Journal : Experimental and Clinical Sciences, Vol 23, Pp 570-599 (2024) |
| بيانات النشر: | IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Biology (General) |
| مصطلحات موضوعية: | circrnas, ferroptosis, cancer treatment, molecular regulation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Biology (General), QH301-705.5 |
| الوصف: | Cancer poses intricate challenges to treatment due to its complexity and diversity. Ferroptosis and circular RNAs (circRNAs) are emerging as innovative therapeutic avenues amid the evolving landscape of cancer therapy. Extensive investigations into circRNAs reveal their diverse roles, ranging from molecular regulators to pivotal influencers of ferroptosis in cancer cell lines. The results underscore the significance of circRNAs in modulating molecular pathways that impact crucial aspects of cancer development, including cell survival, proliferation, and metastasis. A detailed analysis delineates these pathways, shedding light on the molecular mechanisms through which circRNAs influence ferroptosis. Building upon recent experimental findings, the study evaluates the therapeutic potential of targeting circRNAs to induce ferroptosis. By identifying specific circRNAs associated with the etiology of cancer, this analysis paves the way for the development of targeted therapeutics that exploit vulnerabilities in cancer cells. This review consolidates the existing understanding of ferroptosis and circRNAs, emphasizing their role in cancer therapy and providing impetus for ongoing research in this dynamic field. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1611-2156 |
| العلاقة: | https://www.excli.de/index.php/excli/article/view/7005Test; https://doaj.org/toc/1611-2156Test |
| DOI: | 10.17179/excli2024-7005 |
| الوصول الحر: | https://doaj.org/article/969d1122823048bca9f06d569dbc7844Test |
| رقم الانضمام: | edsdoj.969d1122823048bca9f06d569dbc7844 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16112156 |
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| DOI: | 10.17179/excli2024-7005 |