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المؤلفون: Steven O′Reilly, Albena T. Dinkova-Kostova, John Henderson, Sharadha Dayalan Naidu, Stefan Przyborski, Richard Stratton
المصدر: Cells, 2021, Vol.10(8) [Peer Reviewed Journal]
Cells; Volume 10; Issue 8; Pages: 2053
Cells
Cells, Vol 10, Iss 2053, p 2053 (2021)مصطلحات موضوعية: QH301-705.5, systemic sclerosis, NF-E2-Related Factor 2, medicine.medical_treatment, Down-Regulation, Article, Nrf2, Transforming Growth Factor beta1, Mice, Downregulation and upregulation, Fibrosis, medicine, NAD(P)H Dehydrogenase (Quinone), Animals, Humans, Biology (General), Interleukin 6, chemistry.chemical_classification, Mice, Knockout, Reactive oxygen species, Scleroderma, Systemic, biology, integumentary system, Interleukin-6, fibrosis, Connective Tissue Growth Factor, Succinates, General Medicine, Transforming growth factor beta, Fibroblasts, medicine.disease, C700, Connective tissue disease, Molecular biology, Antioxidant Response Elements, Up-Regulation, Heme oxygenase, MicroRNAs, Cytokine, chemistry, itaconate, biology.protein, metabolism, Collagen, Reactive Oxygen Species, Heme Oxygenase-1
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca68670e6790373ccb3a2ff9f8bbf0fTest
http://dro.dur.ac.uk/35213Test/ -
2KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease
المؤلفون: Sharadha Dayalan Naidu, Albena T. Dinkova-Kostova
المصدر: Open Biology
Open Biology, Vol 10, Iss 6 (2020)مصطلحات موضوعية: Models, Molecular, Proteasome Endopeptidase Complex, antioxidant, NF-E2-Related Factor 2, Immunology, Inflammation, Review, Review Article, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, NRF2, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, medicine, Humans, Molecular Targeted Therapy, lcsh:QH301-705.5, cysteine, Transcription factor, anti-inflammatory, 030304 developmental biology, Clinical Trials as Topic, 0303 health sciences, Kelch-Like ECH-Associated Protein 1, biology, General Neuroscience, Ubiquitination, respiratory system, KEAP1, Cytoprotection, Cell biology, Ubiquitin ligase, lcsh:Biology (General), redox, 030220 oncology & carcinogenesis, Chronic Disease, biology.protein, medicine.symptom, Cullin, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7017809c3d739b04628aa127f1f19a38Test
https://doi.org/10.1098/rsob.200105Test -
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المؤلفون: John D. Hayes, Albena T. Dinkova-Kostova
المصدر: Cancer cell. 32(5)
مصطلحات موضوعية: 0301 basic medicine, Genetics, Cancer Research, Kelch-Like ECH-Associated Protein 1, Oncogene, NF-E2-Related Factor 2, Stress signaling, Drug Resistance, Signal transducing adaptor protein, Cell Biology, Biology, KEAP1, Ubiquitin ligase, Cell biology, 03 medical and health sciences, 030104 developmental biology, Oncology, Neoplasms, Cancer cell, biology.protein, Humans, Gene, Adaptor Proteins, Signal Transducing
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef48c39e6257f18a27ee33f2fabf5fcTest
https://pubmed.ncbi.nlm.nih.gov/29033244Test -
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المؤلفون: Colúm Connolly, Clemens Steegborn, Donald C. Lo, Albena T. Dinkova-Kostova, Andrew Snyder, Vanita Chopra, Alexei Degterev, Michael A. Schwarzschild, Cho Low, Ulrike Träger, Leslie M. Thompson, Michael J. Van Kanegan, James R. Miller, Matthew Fuszard, Ningzhe Zhang, Ellen Sapp, Susanta Samajdar, Lisa Meisel, Kimberly B. Kegel-Gleason, Petr Vodicka, Adelaide Tousley, Lisa M. Ellerby, David Llères, Sébastien Moniot, Aleksey G. Kazantsev, Steven M. Hersch, Lisa A. Crawford, Ross S. Stein, Sarah J. Tabrizi, Eranthie Weerapana, Vijay Potluri, Linda S. Kaltenbach, Ruth Farmer, Blair R. Leavitt, Maureen Higgins, Luisa Quinti, Marian DiFiglia, Sharadha Dayalan Naidu, Xiqun Chen
المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 23
مصطلحات موضوعية: 0301 basic medicine, Huntington's Disease, Male, Protein Conformation, Neurodegenerative, Inbred C57BL, environment and public health, Mice, Neural Stem Cells, NRF2 inducer, 2.1 Biological and endogenous factors, Aetiology, Cells, Cultured, Multidisciplinary, Cultured, Kelch-Like ECH-Associated Protein 1, biology, Microglia, Signal transducing adaptor protein, Brain, Middle Aged, respiratory system, Neural stem cell, Ubiquitin ligase, Cell biology, medicine.anatomical_structure, Huntington Disease, Neuroprotective Agents, Biochemistry, PNAS Plus, Cytokines, Female, Signal transduction, KEAP1/NRF2/ARE signaling, Huntington’s disease, Signal Transduction, Adult, antiinflammatory responses, NF-E2-Related Factor 2, Cells, 1.1 Normal biological development and functioning, digestive system, Proinflammatory cytokine, 03 medical and health sciences, Rare Diseases, Huntington's disease, Clinical Research, Underpinning research, medicine, Genetics, Animals, Humans, Transcription factor, Aged, Animal, Macrophages, Neurosciences, MPTP Poisoning, medicine.disease, Stem Cell Research, Brain Disorders, Rats, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, human neural stem cells, HEK293 Cells, Disease Models, biology.protein
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bba6be10075b3b40875d35cd1e72bd7Test
https://researchonline.lshtm.ac.uk/id/eprint/3931063/1/KEAP1.pdfTest -
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المؤلفون: Kusal T. G. Samarasinghe, Young Hoon Ahn, Philip A. Cole, Ying Zhang, A. Pheely, G. C. Van Hecke, Albena T. Dinkova-Kostova, Ivor J. Benjamin, Robert N. Cole, Tatiana Boronina, S. Dayalan Naidu
المصدر: British Journal of Cancer
مصطلحات موضوعية: Cancer Research, Molecular Sequence Data, Hsp90, Breast Neoplasms, HSP72 Heat-Shock Proteins, Cell Growth Processes, Biology, HSF1, NRF2, Hsp90 inhibitor, Mice, 03 medical and health sciences, chemistry.chemical_compound, Adenosine Triphosphate, 0302 clinical medicine, Cell Line, Tumor, Heat shock protein, Animals, Humans, Amino Acid Sequence, Cysteine, HSP90 Heat-Shock Proteins, Molecular Targeted Therapy, Sulfhydryl Compounds, Cysteine metabolism, 030304 developmental biology, Mice, Knockout, 0303 health sciences, Neoplasm Proteins, Up-Regulation, 3. Good health, Proteostasis, Oncology, chemistry, Biochemistry, Sulfoxides, 030220 oncology & carcinogenesis, Chaperone (protein), MCF-7 Cells, biology.protein, Female, Carbamates, Translational Therapeutics, HeLa Cells
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1597f50dd6ab1eaf2bac1a922b2242adTest
https://doi.org/10.1038/bjc.2013.710Test -
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المؤلفون: Albena T. Dinkova-Kostova, Michael B. Sporn, Hidenori Yoshizawa, Gordon W. Gribble, Chitra Sundararajan, Mark M. Yore, John D. Groopman, Melinda S. Yates, Karen J. Baumgartner, Tadashi Honda, Katherine K. Stephenson, Karen T. Liby, Charlotte R. Williams, Bill D. Roebuck, Darlene B. Royce, Patricia A. Egner, Thomas W. Kensler, Renee Risingsong
المصدر: Cancer Research. 68:6727-6733
مصطلحات موضوعية: Male, Cancer Research, Aflatoxin B1, Administration, Oral, Nitric Oxide Synthase Type II, Apoptosis, Nitric Oxide, medicine.disease_cause, Article, Nitric oxide, DNA Adducts, Mice, chemistry.chemical_compound, NAD(P)H Dehydrogenase (Quinone), medicine, Animals, Humans, Oleanolic Acid, Cells, Cultured, Cell Proliferation, chemistry.chemical_classification, Leukemia, Molecular Structure, biology, Cell growth, Macrophages, Liver Neoplasms, Imidazoles, Cell Differentiation, Phenanthrenes, KEAP1, Rats, Inbred F344, Rats, Nitric oxide synthase, Cell Transformation, Neoplastic, Oncology, chemistry, Biochemistry, biology.protein, Reactive Oxygen Species, Enone, Heme Oxygenase-1, Oxidative stress, Tricyclic
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5335bbad1e0982b09b3d8cde1a722ed1Test
https://doi.org/10.1158/0008-5472.can-08-1123Test -
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المؤلفون: Albena T. Dinkova-Kostova, Renee Risingsong, Nanjoo Suh, Michael B. Sporn, Paul Talalay, Katherine K. Stephenson, Charlotte R. Williams, Darlene B. Royce, Tadashi Honda, Karen T. Liby, Gordon W. Gribble, Chitra Sundararajan
المصدر: Molecular Cancer Therapeutics. 6:2113-2119
مصطلحات موضوعية: Male, Cancer Research, Apoptosis, Pharmacology, Nitric Oxide, Mice, chemistry.chemical_compound, Cell Line, Tumor, Betulinic acid, NAD(P)H Dehydrogenase (Quinone), Animals, Humans, Potency, Betulinic Acid, Cell Proliferation, bcl-2-Associated X Protein, Inflammation, chemistry.chemical_classification, biology, Chemistry, Macrophages, Fibroblasts, Antineoplastic Agents, Phytogenic, Triterpenes, In vitro, Nitric oxide synthase, Enzyme, Oncology, Biochemistry, Cytoprotection, Cell culture, Cancer cell, biology.protein, Pentacyclic Triterpenes
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af07d37feaa0f1ccb23a3658e072dc3Test
https://doi.org/10.1158/1535-7163.mct-07-0180Test -
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المؤلفون: Jed W. Fahey, Katherine K. Stephenson, Albena T. Dinkova-Kostova, Thomas W. Kensler, Paul Talalay, Patricia A. Egner
المصدر: Carcinogenesis. 26:1247-1255
مصطلحات موضوعية: Chlorophyll, Cancer Research, Carcinoma, Hepatocellular, Quinone oxidoreductase, Antioxidants, Mice, chemistry.chemical_compound, Tumor Cells, Cultured, Animals, Enzyme inducer, Carotenoid, chemistry.chemical_classification, Chlorophyllides, biology, Chlorophyllin, Liver Neoplasms, General Medicine, NAD(P)H Dehydrogenase (Quinone), Zeaxanthin, Gene Expression Regulation, Tetrapyrroles, chemistry, Biochemistry, Cytoprotection, Enzyme Induction, Chlorin, biology.protein
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a1d6d2630b06bef240dfc6e86cd495Test
https://doi.org/10.1093/carcin/bgi068Test -
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المؤلفون: Ronald J. Hicks, Paul Talalay, Albena T. Dinkova-Kostova, Richard E. Bozak, Michael A. Massiah
المصدر: Proceedings of the National Academy of Sciences. 98:3404-3409
مصطلحات موضوعية: Carcinoma, Hepatocellular, Magnetic Resonance Spectroscopy, FMN Reductase, Stereochemistry, Substituent, Cyclopentanes, Alkylation, Benzylidene Compounds, Mice, chemistry.chemical_compound, Chalcone, Nucleophile, Coumarins, Tumor Cells, Cultured, Animals, Humans, NADH, NADPH Oxidoreductases, Inducer, Sulfhydryl Compounds, Enzyme inducer, Glutathione Transferase, Multidisciplinary, Molecular Structure, biology, Cyclohexanones, Liver Neoplasms, Glutathione, Biological Sciences, Butanones, chemistry, Cinnamates, Enzyme Induction, Electrophile, Commentary, biology.protein, Michael reaction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04739a07e80d79972f98c1f020ca324bTest
https://doi.org/10.1073/pnas.051632198Test -
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المؤلفون: Liam Baird, Albena T. Dinkova-Kostova, Sam Swift, David Llères
المساهمون: Institut de Génétique Moléculaire de Montpellier (IGMM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)
المصدر: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110 (28), pp.15259--64. ⟨10.1073/pnas.1305687110⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110 (38), pp.15259-15264. ⟨10.1073/pnas.1305687110⟩مصطلحات موضوعية: NF-E2-Related Factor 2, Protein Conformation, [SDV]Life Sciences [q-bio], [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, digestive system, environment and public health, Protein–protein interaction, 03 medical and health sciences, Mice, 0302 clinical medicine, Ubiquitin, Stress, Physiological, Fluorescence Resonance Energy Transfer, Animals, Humans, Protein Interaction Domains and Motifs, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Cloning, Molecular, Gene, Transcription factor, [SDV.BDD]Life Sciences [q-bio]/Development Biology, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Adaptor Proteins, Signal Transducing, 0303 health sciences, Multidisciplinary, Kelch-Like ECH-Associated Protein 1, biology, Signal transducing adaptor protein, respiratory system, Biological Sciences, KEAP1, Ubiquitin ligase, Cell biology, Cytoskeletal Proteins, Förster resonance energy transfer, HEK293 Cells, Gene Expression Regulation, Microscopy, Fluorescence, 030220 oncology & carcinogenesis, Multiprotein Complexes, Proteolysis, biology.protein, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3240dfd5aae6b5ec7dea146773027218Test
https://hal.archives-ouvertes.fr/hal-02192863Test