التفاصيل البيبلوغرافية
| العنوان: |
Visceral Fatness and Insulin Sensitivity in Women With a Previous History of Gestational Diabetes Mellitus. |
| المؤلفون: |
Soo Lim, Sung Hee Choi, Young Joo Park, Kyong Soo Park, Hong Kyu Lee, Jang, Hak C., Cho, Nam H., Metzger, Boyd E. |
| المصدر: |
Diabetes Care; Feb2007, Vol. 30 Issue 2, p348-353, 6p, 2 Charts, 1 Graph |
| مصطلحات موضوعية: |
INSULIN resistance, DIABETES in women, TYPE 2 diabetes, OVERWEIGHT women, GLUCOSE tolerance tests, BIOELECTRIC impedance, TOMOGRAPHY |
| مستخلص: |
OBJECTIVE -- The purpose of this study was to investigate the insulin sensitivity and visceral fatness in women with previous gestational diabetes mellitus (GDM), who are prone to develop type 2 diabetes. RESEARCH DESIGN AND METHODS -- A 75-g oral glucose tolerance test (OGTT) performed 1 year postpartum identified 21 GAD- women with previous GDM and impaired glucose tolerance (GDM-IGT). Sixty age- and BMI-matched women with normal glucose tolerance (GDM-NGT) were selected by 1:3 matching to the GDM-IGT group. Another 18 women with normal glucose metabolism during a previous pregnancy and no family history of diabetes were recruited as the normal control group. Age and BMI matching was performed using a range of ± 1.0 years and ± 1.0 kg/m², respectively. Total body fat was measured by tetrapolar bioelectrical impedance, and visceral fat was determined using a single cut of a computed tomography scan. Insulin sensitivity was determined by the minimal model technique using the frequently sampled intravenous glucose tolerance test. RESULTS -- One year postpartum, visceral fat was greater in the GDM-IGT group than in the age- and BMI-matched GDM-NGT or normal control groups. The insulin sensitivity index was lower in the GDM-IGT group than in the GDM-NGT or normal control groups. β-Cell function, as measured by the acute insulin response to glucose, was also lower in GDM-IGT. CONCLUSIONS -- High body fat content, especially visceral fat content, and a low insulin response to glucose seem to contribute simultaneously to the development of impaired glucose metabolism in Korean women with previous GDM. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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