Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes
| العنوان: | Apple procyanidins promote mitochondrial biogenesis and proteoglycan biosynthesis in chondrocytes |
|---|---|
| المؤلفون: | Yu Mizutani, Koutaro Yokote, Koichi Sashihara, Takahiko Shimizu, Yoko Sawada, Hidetoshi Nojiri, Kenji Watanabe, Yusuke Ozawa, Atsushi Sugimoto, Shohei Nakashima, Isao Masuda, Hiroshi Sugiyama, Masato Koike |
| المصدر: | Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018) Scientific Reports |
| بيانات النشر: | Nature Portfolio, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Cartilage, Articular, Male, Paraquat, 0301 basic medicine, Science, Primary Cell Culture, Gene Expression, DNA, Mitochondrial, Article, Cell Line, Mice, 03 medical and health sciences, Chondrocytes, Downregulation and upregulation, Osteoarthritis, Coactivator, medicine, Animals, Humans, Proanthocyanidins, Aggrecan, Mice, Knockout, Organelle Biogenesis, Multidisciplinary, biology, Superoxide Dismutase, Cartilage homeostasis, Chemistry, Cartilage, Polyphenols, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Mitochondria, Cell biology, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Mitochondrial biogenesis, Proteoglycan, Malus, biology.protein, bacteria, Medicine, Proteoglycans, Organelle biogenesis |
| الوصف: | Apples are well known to have various benefits for the human body. Procyanidins are a class of polyphenols found in apples that have demonstrated effects on the circulatory system and skeletal organs. Osteoarthritis (OA) is a locomotive syndrome that is histologically characterized by cartilage degeneration associated with the impairment of proteoglycan homeostasis in chondrocytes. However, no useful therapy for cartilage degeneration has been developed to date. In the present study, we detected beneficial effects of apple polyphenols or their procyanidins on cartilage homeostasis. An in vitro assay revealed that apple polyphenols increased the activities of mitochondrial dehydrogenases associated with an increased copy number of mitochondrial DNA as well as the gene expression of peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α), suggesting the promotion of PGC-1α-mediated mitochondrial biogenesis. Apple procyanidins also enhanced proteoglycan biosynthesis with aggrecan upregulation in primary chondrocytes. Of note, oral treatment with apple procyanidins prevented articular cartilage degradation in OA model mice induced by mitochondrial dysfunction in chondrocytes. Our findings suggest that apple procyanidins are promising food components that inhibit OA progression by promoting mitochondrial biogenesis and proteoglycan homeostasis in chondrocytes. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdd07287219b05bb081d399cfa2e7f7Test https://doaj.org/article/807631a87310403fad916501ca20c8edTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fbdd07287219b05bb081d399cfa2e7f7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
|---|