دورية أكاديمية
Melatonin Supplementation Improves Glycemic Control While Lowering Oxidative Stress in Type 2 Diabetes
| العنوان: | Melatonin Supplementation Improves Glycemic Control While Lowering Oxidative Stress in Type 2 Diabetes |
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| المؤلفون: | Grieco, Carmine R., Colberg, Sheri R., Somma, C. Thomas, Thompson, Andrew G., Vinik, Aaron I. |
| المصدر: | Human Movement Sciences Faculty Publications |
| بيانات النشر: | ODU Digital Commons |
| سنة النشر: | 2013 |
| المجموعة: | Old Dominion University: ODU Digital Commons |
| مصطلحات موضوعية: | Melatonin, Oxidative stress, Type 2 Diabetes, Hemoglobin A1c, Dietetics and Clinical Nutrition, Endocrinology, Diabetes, and Metabolism, Movement and Mind-Body Therapies |
| الوصف: | The purpose of this investigation was to evaluate the effect of melatonin on glycemic control and oxidative stress (OS) in adults with type 2 diabetes (T2D). Fourteen subjects with T2D (10 female, 4 male; 52.5 ± 5.0 years) were randomly assigned to melatonin (MEL) or placebo groups (PLA) for 42 days, in a crossover design. Subjects ingested 10 mg of MEL or an identical placebo (PLA) 30 minutes prior to sleep. Fasting blood draws occurred at baseline, 42 days, and 84 days. Plasma malondialdehyde, a marker of OS, significantly decreased on MEL (-6.25±2.10 nmol/ml) compared to PLA (0.72±3.30, p=0.028). The change in hemoglobin A1c showed a total improvement of 0.33% following MEL supplementation compared to PLA (-0.24±0.23 % for MEL vs. 0.09±0.21 % for PLA, p=0.01), although no significant changes were noted in fasting plasma glucose or lipid levels. Daily melatonin may diminish OS and enhance glycemic control in adults with T2D. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.odu.edu/hms_fac_pubs/43Test; https://digitalcommons.odu.edu/context/hms_fac_pubs/article/1043/viewcontent/Colberg2013MelatoninSupplementationImprovesGlycemicOCR.pdfTest |
| DOI: | 10.5923/j.diabetes.20130203.02 |
| الإتاحة: | https://doi.org/10.5923/j.diabetes.20130203.02Test https://digitalcommons.odu.edu/hms_fac_pubs/43Test https://digitalcommons.odu.edu/context/hms_fac_pubs/article/1043/viewcontent/Colberg2013MelatoninSupplementationImprovesGlycemicOCR.pdfTest |
| رقم الانضمام: | edsbas.6F44C6CB |
| قاعدة البيانات: | BASE |
| DOI: | 10.5923/j.diabetes.20130203.02 |
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