Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia
| العنوان: | Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia |
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| المؤلفون: | Stephan Ripke, A. Di Florio, Gustavo Turecki, N Bass, Ian Jones, Laura J. Scott, Lisa Hall, Martin Hautzinger, Tracy Air, Sarah Knott, Marcella Rietschel, Christel M. Middeldorp, Patrick J. Brennan, John Strauss, Nicholas G. Martin, Bertram Müller-Myhsok, Tony Davis, Andreas Reif, Katherine Gordon-Smith, Céline S. Reinbold, Urs Heilbronner, Anders Juréus, Stefan Kloiber, Andrew McQuillin, Dan Rujescu, N. Dahmen, Fermin Mayoral-Cleries, Richard M. Myers, Abdel Abdellaoui, Franck Bellivier, Gunnar Morken, Sarah E. Bergen, Manolis Kogevinas, Dorret I. Boomsma, Thomas G. Schulze, Arian Mobascher, Stefanie Heilmann-Heimbach, Sascha B. Fischer, Christine Fraser, Y. Milaneschi, Michael Conlon O'Donovan, Susan L. McElroy, Klaus Lieb, B.W.J.H. Penninx, Helmut Vedder, Fabian Streit, Piotr M. Czerski, Swapnil Awasthi, Lilijana Oruc, Caroline M. Nievergelt, Michael Bauer, Jana Strohmaier, Qingqin S. Li, Bernhard T. Baune, Roel A. Ophoff, S. E. Medland, Marco P. Boks, Gulja Babadjanova, Mark A. Frye, Christian Schmahl, M. M. Nöthen, Nicholas John Craddock, John B. Vincent, Douglas Blackwood, Marion Leboyer, Franziska Degenhardt, C. E. Schwarze, Henriette N. Buttenschøn, Tiffany A. Greenwood, Ole A. Andreassen, Toni-Kim Clarke, Loes M. Olde Loohuis, Scott D. Gordon, Björn H. Schott, Stephanie H. Witt, Stefan Roepke, John I. Nurnberger, S Van der Auwera, Lisa Jones, James D. McKay, André Tadić, Mikael Landén, Guy A. Rouleau, Monika Budde, Grant C.B. Sinnamon, Enda M. Byrne, Bruno Etain, Darja Schendel, Andreas J. Forstner, Cristiana Cruceanu, Srdjan Djurovic, Sara A. Paciga, Ney Alliey-Rodriguez, Joanna Hauser, Enrico Domenici, Peter Hoffmann, Elaine K. Green, Stéphane Jamain, Markus Schwarz, Marian L. Hamshere, Christian Witt, E.J.C. de Geus, Andrew M. McIntosh, Sven Cichon, Ole Mors, Jolanta Lissowska, Josef Frank, Pablo Cervantes, G. Kirov, Howard J. Edenberg, Ina Giegling, Grant W. Montgomery, Lydie Dietl, Martin Preisig, M. J. Owen, Martin Alda, David Curtis, Eli A. Stahl, Gonneke Willemsen, Udo Dannlowski, Rolf Adolfsson, Janice M. Fullerton, Jose Guzman-Parra, Elliot S. Gershon, Peter Holmans, Hans-Jörgen Grabe, Hualin S. Xi, Jens Treutlein, Fabio Rivas, James B. Potash, Martin Bohus, Naomi R. Wray, René S. Kahn, Katrin Gade, Sarah Kittel-Schneider, Anders D. Børglum, Susanne Lucae, Jouke-Jan Hottenga, Joanna M. Biernacka, Liz Forty, Margitta Borrmann-Hassenbach, Martin Jungkunz, Andrea Pfennig, Jutta Kammerer-Ciernioch, Maria Grigoroiu-Serbanescu, Peter R. Schofield, Stefan Herms, Amy Perry, Shashi Hitturlingappa, Markus Leber, Thomas W. Mühleisen, Philip B. Mitchell, Andrew Bethell, Huda Akil |
| المساهمون: | Biological Psychology, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, APH - Methodology, Environmental Policy Analysis, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, APH - Digital Health, Bipolar Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Variabilité de réponse aux Psychotropes (VariaPsy - U1144), Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Université Paris-Est Créteil Val-de-Marne - Faculté de médecine (UPEC Médecine), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Duchange, Nathalie |
| المصدر: | Translational Psychiatry Translational Psychiatry, 7(6). Nature Publishing Group Witt, S H, Streit, F, Jungkunz, M, Frank, J, Awasthi, S, Reinbold, C S, Treutlein, J, Degenhardt, F, Forstner, A J, Heilmann-Heimbach, S, Dietl, L, Schwarze, C E, Schendel, D J, Strohmaier, J, Abdellaoui, A, Adolfsson, R, Air, T M, Akil, H, Lopezz de Alda, M, Alliey-Rodriguez, N, Andreassen, O A, Babadjanova, G, Bass, N J, Bauer, M, Baune, B T, Bellivier, F, Bergen, S E, Bethell, A, Biernacka, J M, Blackwood, D H R, Boks, M P, Boomsma, D I, Børglum, A D, Borrmann-Hassenbach, M, Brennan, P, Budde, M, Buttenschøn, H N, Byrne, E M, Cervantes, P, Clarke, T K, Craddock, N, Cruceanu, C, Curtis, D, de Geus, E J C, Fischer, S B, Hottenga, J-J, Middeldorp, C M, Milaneschi, Y, Penninx, B W J H, Willemsen, G & Bipolar Disorders Working Group of the Psychiatric Genomics Consortium 2017, ' Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia ', Translational Psychiatry, vol. 7, no. 6, pp. e1155 . https://doi.org/10.1038/tp.2017.115Test Witt, S H, Streit, F, Jungkunz, M, Frank, J, Awasthi, S, Reinbold, C S, Treutlein, J, Degenhardt, F, Forstner, A J, Heilmann-Heimbach, S, Dietl, L, Schwarze, C E, Schendel, D, Strohmaier, J, Abdellaoui, A, Adolfsson, R, Air, T M, Akil, H, Alda, M, Alliey-Rodriguez, N, Andreassen, O A, Babadjanova, G, Bass, N J, Bauer, M, Baune, B T, Bellivier, F, Bergen, S, Bethell, A, Biernacka, J M, Blackwood, D H R, Boks, M P, Boomsma, D I, Borglum, A D, Borrmann-Hassenbach, M, Brennan, P, Budde, M, Buttenschon, H N, Byrne, E M, Cervantes, P, Clarke, T-K, Craddock, N, Cruceanu, C, Curtis, D, Czerski, P M, Dannlowski, U, Davis, T, de Geus, E J C, Di Florio, A, Djurovic, S, Domenici, E, Edenberg, H J, Etain, B, Fischer, S B, Forty, L, Fraser, C, Frye, M A, Fullerton, J M, Gade, K, Gershon, E S, Giegling, I, Gordon, S D, Gordon-Smith, K, Grabe, H J, Green, E K, Greenwood, T A, Grigoroiu-Serbanescu, M, Guzman-Parra, J, Hall, L S, Hamshere, M, Hauser, J, Hautzinger, M, Heilbronner, U, Herms, S, Hitturlingappa, S, Hoffmann, P, Holmans, P, Hottenga, J-J, Jamain, S, Jones, I, Jones, L A, Jureus, A, Kahn, R S, Kammerer-Ciernioch, J, Kirov, G, Kittel-Schneider, S, Kloiber, S, Knott, S V, Kogevinas, M, Landen, M, Leber, M, Leboyer, M, Li, Q S, Lissowska, J, Lucae, S, Martin, N G, Mayoral-Cleries, F, McElroy, S L, McIntosh, A M, McKay, J D, McQuillin, A, Medland, S E, Middeldorp, C M, Milaneschi, Y, Mitchell, P B, Montgomery, G W, Morken, G, Mors, O, Muehleisen, T W, Mueller-Myhsok, B, Myers, R M, Nievergelt, C M, Nurnberger, J I, O'Donovan, M C, Loohuis, L M O, Ophoff, R, Oruc, L, Owen, M J, Paciga, S A, Penninx, B W J H, Perry, A, Pfennig, A, Potash, J B, Preisig, M, Reif, A, Rivas, F, Rouleau, G A, Schofield, P R, Schulze, T G, Schwarz, M, Scott, L, Sinnamon, G C B, Stahl, E A, Strauss, J, Turecki, G, Van der Auwera, S, Vedder, H, Vincent, J B, Willemsen, G, Witt, C C, Wray, N R, Xi, H S, Tadic, A, Dahmen, N, Schott, B H, Cichon, S, Noethen, M M, Ripke, S, Mobascher, A, Rujescu, D, Lieb, K, Roepke, S, Schmahl, C, Bohus, M & Rietschel, M 2017, ' Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia ', Translational Psychiatry, vol. 7 . https://doi.org/10.1038/tp.2017.115Test TRANSLATIONAL PSYCHIATRY Translational Psychiatry, 7. Nature Publishing Group Translational psychiatry, vol. 7, no. 6, pp. e1155 Translational Psychiatry, Nature Pub. Group, 2017, 7 (6), pp.e1155. ⟨10.1038/tp.2017.115⟩ Witt, S H, Streit, F, Jungkunz, M, Frank, J, Awasthi, S, Reinbold, C S, Treutlein, J, Degenhardt, F, Forstner, A J, Heilmann-Heimbach, S, Dietl, L, Schwarze, C E, Schendel, D, Strohmaier, J, Abdellaoui, A, Adolfsson, R, Air, T M, Akil, H, Alda, M, Alliey-Rodriguez, N, Andreassen, O A, Babadjanova, G, Bass, N J, Bauer, M, Baune, B T, Bellivier, F, Bergen, S, Bethell, A, Biernacka, J M, Blackwood, D H R, Boks, M P, Boomsma, D I, Borglum, A D, Borrmann-Hassenbach, M, Brennan, P, Budde, M, Buttenschon, H N, Byrne, E M, Cervantes, P, Clarke, T-K, Craddock, N, Cruceanu, C, Curtis, D, Czerski, P M, Dannlowski, U, Davis, T, de Geus, E J C, Di Florio, A & Djurovic, S & McIntosh, A M 2017, ' Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia ', Translational Psychiatry, vol. 7, 1155 . https://doi.org/10.1038/tp.2017.115Test Translational Psychiatry 7(6), e1155-(2017). doi:10.1038/tp.2017.115 Witt, S H, Streit, F, Jungkunz, M, Frank, J, Awasthi, S, Reinbold, C S, Treutlein, J, Degenhardt, F, Forstner, A J, Heilmann-Heimbach, S, Dietl, L, Schwarze, C E, Schendel, D, Strohmaier, J, Abdellaoui, A, Adolfsson, R, Air, T M, Akil, H, Alda, M, Alliey-Rodriguez, N, Andreassen, O A, Babadjanova, G, Bass, N J, Bauer, M, Baune, B T, Bellivier, F, Bergen, S, Bethell, A, Biernacka, J M, Blackwood, D H R, Boks, M P, Boomsma, D I, Børglum, A D, Borrmann-Hassenbach, M, Brennan, P, Budde, M, Buttenschøn, H N, Byrne, E M, Cervantes, P, Clarke, T-K, Fischer, S B, Gade, K, Hall, L S, Hoffmann, P, Jones, L A, Li, Q S, Mors, O, Schwarz, M, Stahl, E A, Witt, C C & Bipolar Disorders Working Group of the Psychiatric Genomics Consortium 2017, ' Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia ', Translational Psychiatry, vol. 7, no. 6, pp. e1155 . https://doi.org/10.1038/tp.2017.115Test Translational psychiatry |
| بيانات النشر: | Freie Universität Berlin, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Netherlands Twin Register (NTR), Male, Linkage disequilibrium, Multifactorial Inheritance, Bipolar Disorder, FEATURES, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Genome-wide association study, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit, MESH: Genotype, 0302 clinical medicine, Borderline Personality Disorder, MESH: Bipolar Disorder, Borderline personality disorder, Genetics, RISK, Psychiatry, MESH: Aged, MESH: Middle Aged, PSYCHOPATHOLOGY, MESH: Genetic Predisposition to Disease, Middle Aged, MESH: Case-Control Studies, 3. Good health, FAMILY, Psychiatry and Mental health, Schizophrenia, MESH: Young Adult, Female, Original Article, medicine.symptom, Psychology, SET, TRAITS, Adolescent, Adult, Aged, Bipolar Disorder/genetics, Borderline Personality Disorder/genetics, Case-Control Studies, Depressive Disorder, Major/genetics, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Schizophrenia/genetics, Young Adult, Clinical psychology, MESH: Depressive Disorder, Major, TWIN, BF, Impulsivity, Psykiatri, 03 medical and health sciences, Cellular and Molecular Neuroscience, medicine, Journal Article, ddc:610, Bipolar disorder, Biological Psychiatry, METAANALYSIS, MESH: Borderline Personality Disorder, MESH: Adolescent, Depressive Disorder, Major, MESH: Humans, MESH: Adult, medicine.disease, Comorbidity, MESH: Male, MESH: Schizophrenia, 030227 psychiatry, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, MESH: Genome-Wide Association Study, PATTERNS, RC0321, DPYD, MESH: Multifactorial Inheritance, COMORBIDITY, MESH: Female, 030217 neurology & neurosurgery |
| الوصف: | Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case–control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes: DPYD (P=4.42 × 10−7) and PKP4 (P=8.67 × 10−7); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887, PFDR=0.019; FDR, false discovery rate). Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (rg=0.28 [P=2.99 × 10−3]), SCZ (rg=0.34 [P=4.37 × 10−5]) and MDD (rg=0.57 [P=1.04 × 10−3]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2158-3188 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feef93fa89a41f8b57dbe34156009307Test https://doi.org/10.17169/refubium-24737Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....feef93fa89a41f8b57dbe34156009307 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21583188 |
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