التفاصيل البيبلوغرافية
| العنوان: |
Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019. |
| المؤلفون: |
Rubin, Sébastien, Orieux, Arthur, Prevel, Renaud, Garric, Antoine, Bats, Marie-Lise, Dabernat, Sandrine, Camou, Fabrice, Guisset, Olivier, Issa, Nahema, Mourissoux, Gaelle, Dewitte, Antoine, Joannes-Boyau, Olivier, Fleureau, Catherine, Rozé, Hadrien, Carrié, Cédric, Petit, Laurent, Clouzeau, Benjamin, Sazio, Charline, Bui, Hoang-Nam, Pillet, Odile |
| المصدر: |
Clinical Kidney Journal; Jun2020, Vol. 13 Issue 3, p354-361, 8p |
| مصطلحات موضوعية: |
COVID-19, ACUTE kidney failure, CRITICALLY ill, INTENSIVE care units, KIDNEY diseases |
| مصطلحات جغرافية: |
FRANCE |
| مستخلص: |
Background Coronavirus disease 2019 (COVID-19)-associated acute kidney injury (AKI) frequency, severity and characterization in critically ill patients has not been reported. Methods Single-centre cohort performed from 3 March 2020 to 14 April 2020 in four intensive care units in Bordeaux University Hospital, France. All patients with COVID-19 and pulmonary severity criteria were included. AKI was defined using Kidney Disease: Improving Global Outcomes (KDIGO) criteria. A systematic urinary analysis was performed. The incidence, severity, clinical presentation, biological characterization (transient versus persistent AKI; proteinuria, haematuria and glycosuria) and short-term outcomes were evaluated. Results Seventy-one patients were included, with basal serum creatinine (SCr) of 69 ± 21 µmol/L. At admission, AKI was present in 8/71 (11%) patients. Median [interquartile range (IQR)] follow-up was 17 (12–23) days. AKI developed in a total of 57/71 (80%) patients, with 35% Stage 1, 35% Stage 2 and 30% Stage 3 AKI; 10/57 (18%) required renal replacement therapy (RRT). Transient AKI was present in only 4/55 (7%) patients and persistent AKI was observed in 51/55 (93%). Patients with persistent AKI developed a median (IQR) urine protein/creatinine of 82 (54–140) (mg/mmol) with an albuminuria/proteinuria ratio of 0.23 ± 20, indicating predominant tubulointerstitial injury. Only two (4%) patients had glycosuria. At Day 7 after onset of AKI, six (11%) patients remained dependent on RRT, nine (16%) had SCr >200 µmol/L and four (7%) had died. Day 7 and Day 14 renal recovery occurred in 28% and 52%, respectively. Conclusion Severe COVID-19-associated AKI is frequent, persistent, severe and characterized by an almost exclusive tubulointerstitial injury without glycosuria. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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