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المؤلفون: John D. Hayes, Albena T. Dinkova-Kostova, Kenneth D. Tew
المصدر: Cancer Cell
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Apoptosis, Pentose phosphate pathway, medicine.disease_cause, Article, Antioxidants, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, medicine, Animals, Humans, HSF1, Transcription factor, chemistry.chemical_classification, Reactive oxygen species, AMPK, Cell Biology, Cell biology, Oxidative Stress, Glucose, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, Cancer cell, Energy Metabolism, Reactive Oxygen Species, Carcinogenesis, NADP, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15eff6d207e38ee78ac1ab60ade16d2Test
https://doi.org/10.1016/j.ccell.2020.06.001Test -
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المؤلفون: Tatsuro Iso, Geoffrey Wells, Seizo Koshiba, Takafumi Suzuki, Takashi Kamei, Albena T. Dinkova-Kostova, Jin Inoue, Yuta Horie, Tsunehiro Mizushima, Terry W. Moore, Masayuki Yamamoto, Takuma Kasai
المصدر: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Communications Biologyمصطلحات موضوعية: 0301 basic medicine, Molecular biology, NF-E2-Related Factor 2, Protein Conformation, QH301-705.5, Hinge, Medicine (miscellaneous), digestive system, environment and public health, Article, General Biochemistry, Genetics and Molecular Biology, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Humans, Protein Interaction Domains and Motifs, Inducer, Biology (General), Binding Sites, Kelch-Like ECH-Associated Protein 1, Mechanism (biology), Chemistry, Nuclear magnetic resonance spectroscopy, respiratory system, Cytoprotection, KEAP1, Keap1 nrf2, 030104 developmental biology, 030220 oncology & carcinogenesis, Biophysics, Disease prevention, General Agricultural and Biological Sciences, Solution-state NMR, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64b389db1174491fece623799eefbceTest
https://doi.org/10.1038/s42003-021-02100-6Test -
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المؤلفون: Tim De Meyer, Louis Coussement, Maureen Higgins, Elena V. Knatko, Albena T. Dinkova-Kostova, Sandra Steyaert, Charlotte M. Proby, Kevin Roth
المصدر: EBIOMEDICINE
EBioMedicine, Vol 67, Iss, Pp 103383-(2021)
EBioMedicineمصطلحات موضوعية: 5mC, 5-methylcytosine, 0301 basic medicine, Medicine (General), DOWN-REGULATION, Research paper, Skin Neoplasms, NHK, normal human keratinocyte, Bisulfite sequencing, iHS, independent healthy skin, Mice, chemistry.chemical_compound, 0302 clinical medicine, DS, dorsal skin, Medicine and Health Sciences, Filip1l, Filament A interacting protein 1-like, iso, isoform, 5hmC, 5-hydroxymethylcytosine, cSCC, cutaneous squamous cell carcinoma, DNA methylation, CARCINOGENESIS, DMR, differentially methylated region, General Medicine, Methylation, Gene Expression Regulation, Neoplastic, 5-Methylcytosine, CpG site, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, CGI, CpG island, Medicine, cSCC, INTERACTING PROTEIN 1-LIKE, EXPRESSION, NMSC, non-melanoma skin cancer, INHIBITION, Down-Regulation, CpG, 5′-Cytosinephosphate-Guanine-3′, Biology, FILIP1L, General Biochemistry, Genetics and Molecular Biology, UVR, Ultraviolet radiation, 03 medical and health sciences, Tet, Ten-eleven-translocase, R5-920, Cell Line, Tumor, BENEFITS, Animals, Humans, Gene, 5-Hydroxymethylcytosine, VS, ventral skin, RRBS, SKIN-CANCER, LANDSCAPE, MUTATIONS, Promoter, (ox)RRBS, (oxidative) reduced representation bisulfite sequencing, ssUV mcSCC, solar simulated mouse cSCC, AK, actinic keratosis, Cytoskeletal Proteins, 030104 developmental biology, chemistry, Cancer research, RADIATION, Carrier Proteins
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9a728692e7f11d9c3617585e44f154Test
https://hdl.handle.net/1854/LU-8741083Test -
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المؤلفون: Holly Robertson, Albena T. Dinkova-Kostova, John D. Hayes
المصدر: Cancers
Cancers, Vol 12, Iss 3609, p 3609 (2020)مصطلحات موضوعية: 0301 basic medicine, Cancer Research, antioxidant, recurrent disease, Review, adaptation, medicine.disease_cause, chemotherapy, environment and public health, head and neck, 0302 clinical medicine, Cullin 3, oncogene, oxidative stress, chemoprevention, rectum, ATF4, glutathione, bladder, reactive oxygen species, NADPH generation, respiratory system, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Oncology, 030220 oncology & carcinogenesis, stomach, autophagy, tumour suppressor, pentose phosphate pathway, Biology, liver, lcsh:RC254-282, digestive system, NRF2, lung, 03 medical and health sciences, Downregulation and upregulation, medicine, metastasis, Protein kinase B, PI3K/AKT/mTOR pathway, bioactivation, drug resistance, oesophagus, colon, Cancer, thioredoxin, medicine.disease, KEAP1, NFE2L2, drug metabolism, initiation, 030104 developmental biology, proteasome, quinone-containing drugs, Cancer research, progression, Carcinogenesis
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14afe79e3e505f682180a1993dd1f57Test
https://pubmed.ncbi.nlm.nih.gov/33276631Test -
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المصدر: Molecules, Vol 24, Iss 19, p 3593 (2019)
Moleculesمصطلحات موضوعية: 0301 basic medicine, Pharmaceutical Science, sulforaphane, Disease, Review, Bioinformatics, Analytical Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Anti-Infective Agents, Isothiocyanates, Drug Discovery, Medicine, nrf2, Glucoraphanin, Clinical Trials as Topic, Molecular Structure, 3. Good health, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Sulfoxides, Chemoprotective, Molecular Medicine, allometric scaling, chemoprotection, Brassica, lcsh:QD241-441, 03 medical and health sciences, lcsh:Organic chemistry, Biomarkers, Tumor, Animals, Humans, Microbiome, Physical and Theoretical Chemistry, broccoli, clinical trials, business.industry, Plant Extracts, glucoraphanin, Organic Chemistry, myrosinase, toxicity, Antineoplastic Agents, Phytogenic, Bioavailability, Clinical trial, 030104 developmental biology, chemistry, Isothiocyanate, business, Sulforaphane
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b2496ac3653b236a87628394c1f7d0Test
https://www.mdpi.com/1420-3049/24/19/3593Test -
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المؤلفون: Stjepana Kovac, Sharadha Dayalan Naidu, Andrey Y. Abramov, Ramona Eckel, Tawfeeq Shekh-Ahmad, Maureen Higgins, Masayuki Yamamoto, Matthew C. Walker, Albena T. Dinkova-Kostova
المصدر: Brain. 141:1390-1403
مصطلحات موضوعية: Male, 0301 basic medicine, Mice, Transgenic, Status epilepticus, Mitochondrion, Pharmacology, medicine.disease_cause, Epileptogenesis, Neuroprotection, Rats, Sprague-Dawley, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, Excitatory Amino Acid Agonists, medicine, Animals, Cells, Cultured, Cerebral Cortex, Membrane Potential, Mitochondrial, Neurons, chemistry.chemical_classification, Hippocampal sclerosis, Reactive oxygen species, Kainic Acid, Kelch-Like ECH-Associated Protein 1, medicine.disease, Glutathione, Triterpenes, Rats, Disease Models, Animal, Oxidative Stress, 030104 developmental biology, Animals, Newborn, Gene Expression Regulation, chemistry, Mutation, Anticonvulsants, Neurology (clinical), medicine.symptom, Neuroglia, 030217 neurology & neurosurgery, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1761aa3e6338da370b0cc3a5957f4cTest
https://doi.org/10.1093/brain/awy071Test -
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المؤلفون: Jennifer E. Gallagher, Dorothy Kisielewski, John F. Dillon, Shaun V. Walsh, Diane Cassidy, David J. Harrison, Ritu Sharma, Tadashi Honda, John D. Hayes, Alison D. McNeilly, Michael L.J. Ashford, Albena T. Dinkova-Kostova, Rory J. McCrimmon
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 3, Pp 367-398 (2018)مصطلحات موضوعية: NQO1, NAD(P)H:quinone oxidoreductase 1, TNF-α, tumor necrosis factor-α, IRE1α, inositol requiring kinase-1α, SCAD, short-chain acyl-CoA dehydrogenase, C/EBP, CCAAT/enhancer-binding protein, PCR, polymerase chain reaction, UPR, unfolded protein response, 0302 clinical medicine, Fibrosis, MGPAT, mitochondrial glycerol-3-phosphate acetyltransferase, ATF4, activating transcription factor-4, DGAT2, diacylglycerol acyltransferase-2, LXRα, liver X receptor α, Glucose homeostasis, eIf2α, eukaryotic translation initiation factor 2A, IKK, IκB kinase, ACOT7, acetyl-CoA thioesterase 7, Original Research, TGFβ, transforming growth factor beta-1, SLC7A11, solute carrier family 7 member 11, GSSG, oxidized glutathione, MTTP, microsomal triglyceride transfer protein, NASH, Gastroenterology, TXN1, thioredoxin-1, 3. Good health, ChREBP, carbohydrate-responsive element-binding protein, 030220 oncology & carcinogenesis, NASH, nonalcoholic steatohepatitis, medicine.medical_specialty, PARP, poly ADP ribose polymerase, qRT-PCR, quantitative reverse transcriptase PCR, GSTM1, glutathione S-transferase Mu-1, GCLC, glutamate-cysteine ligase catalytic, Nrf2, ACACA, acetyl-CoA carboxylase alpha, 03 medical and health sciences, FXR, farnesoid X receptor, Nrf2, NF-E2 p45-related factor 2, COX2, cyclooxygenase-2, Keap1, Kelch-like ECH-associated protein-1, PPARα, peroxisome proliferator-activated receptor α, PTT, pyruvate tolerance test, HMOX1, heme oxygenase-1, RC, regular chow, p58IPK, p58 inhibitor of the PKR kinase, medicine.disease, TBE-31, 030104 developmental biology, Endocrinology, COL1A1, collagen, type I, alpha-1, Unfolded protein response, CAT, catalase, 0301 basic medicine, PDI, protein disulfide isomerase, GSH, reduced glutathione, FASN, fatty acid synthase, BCL-2, B-cell lymphoma, MPO, myeloperoxidase, AP-1, activator protein 1, DMSO, dimethyl sulfoxide, medicine.disease_cause, SHP, small heterodimer partner, CDDO, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid, CHOP, C/EBP homologous protein, TXNRD1, thioredoxin reductase-1, HF30Fr, high-fat diet with 30% fructose in drinking water, IκB, inhibitor of NF-κB, SFN, sulforaphane, ADRP, adipose differentiation-related protein, NAS, NAFLD activity score, GPX2, glutathione peroxidase-2, Chemistry, MCP-1, monocyte chemotactic protein-1, XBP1, X-box binding protein-1, SREBP-1c, sterol regulatory element-binding protein-1c, Lipogenesis, GTT, glucose tolerance test, PERK, PRK-like endoplasmic reticulum kinase, PTGR1, prostaglandin reductase-1, GSTA4, glutathione S-transferase Alpha-4, medicine.symptom, NAFLD, non-alcoholic fatty liver disease, α-SMA, alpha smooth muscle actin, ACOX2, acetyl-CoA oxidase 2, HFFr, high-fat diet with fructose in drinking water, NF-κB, nuclear factor-κB, GCLM, glutamate-cysteine ligase modifier, Inflammation, JNK1, c-Jun N-terminal kinase 1, CD36, cluster of differentiation 36, ER, endoplasmic reticulum, Insulin resistance, HF, high-fat, HF55Fr, high-fat diet with 55% fructose in drinking water, Internal medicine, ATF6, activating transcription factor-6, medicine, ApoB, apolipoprotein B, lcsh:RC799-869, CES1G, carboxylesterase 1g, ITT, insulin tolerance test, MCD, methionine- and choline-deficient, ACLY, ATP citrate lyase, Hepatology, SCD1, stearoyl-CoA desaturase-1, NOS2, nitric oxide synthase-2, PRDX6, peroxiredoxin 6, PPARγ, peroxisome proliferator-activated receptor γ, BIP, binding immunoglobulin protein, H&E, hematoxylin and eosin, lcsh:Diseases of the digestive system. Gastroenterology, Steatosis, CPT1A, carnitine palmitoyltransferase 1a, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdd8de56b5ba950a8c970d72cce7012Test
https://doi.org/10.1016/j.jcmgh.2017.11.016Test -
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المؤلفون: Albena T. Dinkova-Kostova, Sharadha Dayalan Naidu
المصدر: The FEBS Journal. 284:1606-1627
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Proteasome Endopeptidase Complex, Protein Folding, Hot Temperature, Transcription, Genetic, Protein Conformation, SUMO protein, Biology, Biochemistry, 03 medical and health sciences, Heat Shock Transcription Factors, Stress, Physiological, Heat shock protein, Animals, Phosphorylation, HSF1, Molecular Biology, Transcription factor, Phylogeny, Mammals, Sumoylation, Acetylation, Cell Biology, Adaptation, Physiological, Cell biology, DNA-Binding Proteins, 030104 developmental biology, Gene Expression Regulation, Chaperone complex, Protein folding, Protein Processing, Post-Translational, Transcription Factors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4823cd8ceb87348f85f0930fa35722bTest
https://doi.org/10.1111/febs.13999Test -
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المؤلفون: Luke A. J. O'Neill, Dave Speijer, Esther Lutgens, Michel van Weeghel, Annette E. Neele, Koen H.M. Prange, Saskia van der Velden, Albena T. Dinkova-Kostova, Menno P.J. de Winther, Rob C. I. Wüst, Jeroen Baardman, Maarten E. Witte, Simone Denis, Jan Van den Bossche, Elena V. Knatko, Dylan G. Ryan, Sanne G.S. Verberk, Riekelt H. Houtkooper
المساهمون: Molecular cell biology and Immunology, Physiology, Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Atherosclerosis & ischemic syndromes, Graduate School, Medical Biochemistry, AII - Inflammatory diseases, Laboratory Genetic Metabolic Diseases, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, AMS - Ageing & Morbidty, ACS - Amsterdam Cardiovascular Sciences, AII - Amsterdam institute for Infection and Immunity, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, APH - Aging & Later Life, AGEM - Endocrinology, metabolism and nutrition, AGEM - Inborn errors of metabolism, ARD - Amsterdam Reproduction and Development
المصدر: Cell Reports, 25(8), 2044-2052.e5. Cell Press
Baardman, J, Verberk, S G S, Prange, K H M, van Weeghel, M, van der Velden, S, Ryan, D G, Wüst, R C I, Neele, A E, Speijer, D, Denis, S W, Witte, M E, Houtkooper, R H, O'neill, L A, Knatko, E V, Dinkova-Kostova, A T, Lutgens, E, de Winther, M P J & Van den Bossche, J 2018, ' A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia ', Cell Reports, vol. 25, no. 8, pp. 2044-2052.e5 . https://doi.org/10.1016/j.celrep.2018.10.092Test, https://doi.org/10.1016/j.celrep.2018.10.092Test
Cell reports, 25(8), 2044-2052. Cell Press
Cell Reports, Vol 25, Iss 8, Pp 2044-2052.e5 (2018)
Baardman, J, Verberk, S G S, Prange, K H M, van Weeghel, M, van der Velden, S, Ryan, D G, Wüst, R C I, Neele, A E, Speijer, D, Denis, S W, Witte, M E, Houtkooper, R H, O'neill, L A, Knatko, E V, Dinkova-Kostova, A T, Lutgens, E, de Winther, M P J & Van den Bossche, J 2018, ' A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia ', Cell Reports, vol. 25, no. 8, pp. 2044-2052.e5 . https://doi.org/10.1016/j.celrep.2018.10.092Testمصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Male, NF-E2-Related Factor 2, Citric Acid Cycle, immunometabolism, pentose phosphate pathway, Inflammation, Pentose phosphate pathway, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Nrf2, 03 medical and health sciences, 0302 clinical medicine, Immune system, SDG 3 - Good Health and Well-being, cardiovascular disease, medicine, Macrophage, Animals, lcsh:QH301-705.5, hypercholesterolemia, Chemistry, meta-inflammation, Metabolism, metabolic disease, foam cells, Cell biology, macrophages, Mice, Inbred C57BL, 030104 developmental biology, Cell metabolism, lcsh:Biology (General), inflammation, 030220 oncology & carcinogenesis, Cytokine secretion, Female, medicine.symptom, atherosclerosis, Glycolysis, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ef415f4ba7df2f11e9a8a4f10fe79fTest
https://research.vumc.nl/en/publications/18d3e0ec-b7da-4ccb-bcdd-e585bd6780daTest -
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المؤلفون: Albena T. Dinkova-Kostova, Filip Cvetko, Hiran A. Prag, Michael P. Murphy, Stuart T. Caldwell, Maureen Higgins, Takafumi Suzuki, Richard C. Hartley, Masayuki Yamamoto
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: 0301 basic medicine, GCLC, glutamate–cysteine ligase catalytic subunit, thiol oxidation, Mitochondrion, Biochemistry, FB, fractionation buffer, NQO1, NAD(P)H:quinone oxidoreductase-1, Mice, chemistry.chemical_compound, DNM1L, Superoxides, energy metabolism, Homeostasis, Hydrogen peroxide, Cells, Cultured, HO-1, heme oxygenase-1, NAC, N-acetyl-L-cysteine, SFN, sulforaphane, chemistry.chemical_classification, Kelch-Like ECH-Associated Protein 1, Nrf2, nuclear factor erythroid 2–related factor 2, respiratory system, DRP1, dynamin-related protein 1, Glutathione, Mitochondria, Cell biology, CDNB, 1-chloro-2,4-dinitrobenzene, Keap1, Kelch-like ECH-associated protein 1, TRX, thioredoxin, Thioredoxin, Oxidation-Reduction, Research Article, Signal Transduction, NF-E2-Related Factor 2, reactive oxygen species (ROS), Nrf2, MitoPQ, MitoParaquat, 03 medical and health sciences, MitoCDNB, CD, concentration required to double, ROS, reactive oxygen species, PGAM5, phosphoglycerate mutase family member 5, Animals, TRXR2, TRX reductase 2, Cysteine, Sulfhydryl Compounds, redox signaling, Molecular Biology, Reactive oxygen species, 030102 biochemistry & molecular biology, Cell Biology, ACN, acetonitrile, MitoCDNB, MitoChlorodinitrobenzoic acid, GSS, GSH synthetase, MEF, mouse embryonic fibroblast, KEAP1, 030104 developmental biology, chemistry, BSA, bovine serum albumin, MitoPQ
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0523882756133409621203d90cd5225Test
https://doi.org/10.1074/jbc.ra120.016551Test