المؤلفون: Darmency-Stamboul, Véronique, Chantegret, Corinne, Ferdynus, Cyril, Méjean, Nathalie, Durand, Christine, Sagot, Paul, Giroud, Maurice, Béjot, Yannick, Gouyon, Jean-Bernard

المساهمون: Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), NICU - pediatric departement, Centre d'épidémiologie des populations (CEP), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc Dijon (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Service Biostatistiques et Informatique Médicale (CHU de Dijon) (DIM), Service de radiologie et d'Imagerie médicale diagnostique et thérapeutique (CHU de Dijon), Service de Gynécologie Obstétrique, Médecine Foetale et Stérilité Conjugale - Chirurgie Gynécologie et Oncologique CHU de Dijon, Centre d'Études Périnatales de l'Océan Indien (CEPOI), Université de La Réunion (UR)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion)

المصدر: ISSN: 0039-2499.

مصطلحات موضوعية: Adult, Brain Ischemia, Case-Control Studies, Cerebral Infarction, Databases, Factual, Diabetes, Gestational, Female, France, Functional Laterality, Gestational Age, Humans, Infant, Newborn, Magnetic Resonance Imaging, Male, Multivariate Analysis, Nervous System Diseases, Pregnancy, Retrospective Studies, Risk Factors, Smoking, Stroke, Tomography, X-Ray Computed, Treatment Outcome, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics

الوصف: International audience ; BACKGROUND AND PURPOSE: Perinatal arterial ischemic stroke (PAIS) is a common cause of hemiplegic cerebral palsy in children. The diagnosis of PAIS is based on cerebral imaging. The objective of our study was to determine prenatal risk factors associated with PAIS. METHODS: A retrospective case-control study was nested in the whole population of Burgundy, France, from January 2000 to December 2007. Case patients were confirmed by review of brain imaging and medical records. Three control subjects per case were randomly selected from the study population by sex, term, place, and year of birth. RESULTS: PAIS was confirmed in 32 patients and its incidence was one per 4400 live births. In comparison to control subjects, clinical conditions significantly associated to cases were gestational diabetes (16.1% versus 4.2%; P=0.04), fetal heart rate abnormalities (35.5% versus 10.9%; P=0.001), and meconium-stained liquor (40% versus 12%; P\textless0.001). At the limit of statistical significance were found maternal smoking before (39.3% versus 22.9%; P=0.08) and during pregnancy (32.1% versus 16.7%; P=0.07), cord abnormalities (29% versus 14.1%; P=0.06), and cesarean delivery (28.1% versus 14.6%; P=0.08). In the multivariate analysis, maternal smoking during pregnancy (OR, 3.1; 95% CI, 1.1-8.8; P=0.04) was the only risk factor significantly associated with PAIS. CONCLUSIONS: This study is the first to identify maternal smoking during pregnancy as an independent prenatal risk factor of PAIS. Additional prospective studies are needed to confirm this result and to investigate the role of maternal smoking in fetal and neonatal thrombogenesis.

العلاقة: hal-01194218; https://hal.univ-reunion.fr/hal-01194218Test

الإتاحة: https://doi.org/10.1161/STROKEAHA.111.642181Test
https://hal.univ-reunion.fr/hal-01194218Test

المؤلفون: Darmency-Stamboul, Véronique, Chantegret, Corinne, Ferdynus, Cyril, Méjean, Nathalie, Durand, Christine, Sagot, Paul, Giroud, Maurice, Béjot, Yannick, Gouyon, Jean-Bernard

المساهمون: Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), NICU - pediatric departement, Centre d'épidémiologie des populations (CEP), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc Dijon (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Service Biostatistiques et Informatique Médicale (CHU de Dijon) (DIM), Service de radiologie et d'Imagerie médicale diagnostique et thérapeutique (CHU de Dijon), Service de Gynécologie Obstétrique, Médecine Foetale et Stérilité Conjugale - Chirurgie Gynécologie et Oncologique CHU de Dijon, Centre d'Études Périnatales de l'Océan Indien (CEPOI), Université de La Réunion (UR)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion)

المصدر: ISSN: 0039-2499.

مصطلحات موضوعية: Adult, Brain Ischemia, Case-Control Studies, Cerebral Infarction, Databases, Factual, Diabetes, Gestational, Female, France, Functional Laterality, Gestational Age, Humans, Infant, Newborn, Magnetic Resonance Imaging, Male, Multivariate Analysis, Nervous System Diseases, Pregnancy, Retrospective Studies, Risk Factors, Smoking, Stroke, Tomography, X-Ray Computed, Treatment Outcome, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics

الوصف: International audience ; BACKGROUND AND PURPOSE: Perinatal arterial ischemic stroke (PAIS) is a common cause of hemiplegic cerebral palsy in children. The diagnosis of PAIS is based on cerebral imaging. The objective of our study was to determine prenatal risk factors associated with PAIS. METHODS: A retrospective case-control study was nested in the whole population of Burgundy, France, from January 2000 to December 2007. Case patients were confirmed by review of brain imaging and medical records. Three control subjects per case were randomly selected from the study population by sex, term, place, and year of birth. RESULTS: PAIS was confirmed in 32 patients and its incidence was one per 4400 live births. In comparison to control subjects, clinical conditions significantly associated to cases were gestational diabetes (16.1% versus 4.2%; P=0.04), fetal heart rate abnormalities (35.5% versus 10.9%; P=0.001), and meconium-stained liquor (40% versus 12%; P\textless0.001). At the limit of statistical significance were found maternal smoking before (39.3% versus 22.9%; P=0.08) and during pregnancy (32.1% versus 16.7%; P=0.07), cord abnormalities (29% versus 14.1%; P=0.06), and cesarean delivery (28.1% versus 14.6%; P=0.08). In the multivariate analysis, maternal smoking during pregnancy (OR, 3.1; 95% CI, 1.1-8.8; P=0.04) was the only risk factor significantly associated with PAIS. CONCLUSIONS: This study is the first to identify maternal smoking during pregnancy as an independent prenatal risk factor of PAIS. Additional prospective studies are needed to confirm this result and to investigate the role of maternal smoking in fetal and neonatal thrombogenesis.

العلاقة: hal-01194218; https://hal.univ-reunion.fr/hal-01194218Test

الإتاحة: https://doi.org/10.1161/STROKEAHA.111.642181Test
https://hal.univ-reunion.fr/hal-01194218Test

المؤلفون: Darmency-Stamboul, Véronique, Chantegret, Corinne, Ferdynus, Cyril, Méjean, Nathalie, Durand, Christine, SAGOT, Paul, Giroud, Maurice, Béjot, Yannick, Gouyon, Jean-Bernard

المساهمون: Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), NICU - pediatric departement, Centre d'épidémiologie des populations (CEP), Université de Bourgogne (UB)-Centre Régional de Lutte contre le cancer Georges-François Leclerc Dijon (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Service Biostatistiques et Informatique Médicale (CHU de Dijon) (DIM), Service de radiologie et d'Imagerie médicale diagnostique et thérapeutique (CHU de Dijon), Service de Gynécologie Obstétrique, Médecine Foetale et Stérilité Conjugale - Chirurgie Gynécologie et Oncologique CHU de Dijon, Centre d'Études Périnatales de l'Océan Indien (CEPOI), Université de La Réunion (UR)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion)

المصدر: Stroke; a Journal of Cerebral Circulation ; https://hal.univ-reunion.fr/hal-01194218Test ; Stroke; a Journal of Cerebral Circulation, 2012, 43 (9), pp.2307--2312. ⟨10.1161/STROKEAHA.111.642181⟩

مصطلحات موضوعية: Adult, Brain Ischemia, Case-Control Studies, Cerebral Infarction, Databases, Factual, Diabetes, Gestational, Female, France, Functional Laterality, Gestational Age, Humans, Infant, Newborn, Magnetic Resonance Imaging, Male, Multivariate Analysis, Nervous System Diseases, Pregnancy, Retrospective Studies, Risk Factors, Smoking, Stroke, Tomography, X-Ray Computed, Treatment Outcome, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics

الوصف: International audience ; BACKGROUND AND PURPOSE: Perinatal arterial ischemic stroke (PAIS) is a common cause of hemiplegic cerebral palsy in children. The diagnosis of PAIS is based on cerebral imaging. The objective of our study was to determine prenatal risk factors associated with PAIS. METHODS: A retrospective case-control study was nested in the whole population of Burgundy, France, from January 2000 to December 2007. Case patients were confirmed by review of brain imaging and medical records. Three control subjects per case were randomly selected from the study population by sex, term, place, and year of birth. RESULTS: PAIS was confirmed in 32 patients and its incidence was one per 4400 live births. In comparison to control subjects, clinical conditions significantly associated to cases were gestational diabetes (16.1% versus 4.2%; P=0.04), fetal heart rate abnormalities (35.5% versus 10.9%; P=0.001), and meconium-stained liquor (40% versus 12%; P\textless0.001). At the limit of statistical significance were found maternal smoking before (39.3% versus 22.9%; P=0.08) and during pregnancy (32.1% versus 16.7%; P=0.07), cord abnormalities (29% versus 14.1%; P=0.06), and cesarean delivery (28.1% versus 14.6%; P=0.08). In the multivariate analysis, maternal smoking during pregnancy (OR, 3.1; 95% CI, 1.1-8.8; P=0.04) was the only risk factor significantly associated with PAIS. CONCLUSIONS: This study is the first to identify maternal smoking during pregnancy as an independent prenatal risk factor of PAIS. Additional prospective studies are needed to confirm this result and to investigate the role of maternal smoking in fetal and neonatal thrombogenesis.

العلاقة: hal-01194218; https://hal.univ-reunion.fr/hal-01194218Test

الإتاحة: https://doi.org/10.1161/STROKEAHA.111.642181Test
https://hal.univ-reunion.fr/hal-01194218Test