المؤلفون: Mahmoud Agholi, Elham Aliabadi, Gholam Reza Hatam

المصدر: Polish Journal of Pathology, Vol 67, Iss 3, Pp 270-276 (2016)

مصطلحات موضوعية: cholecystitis, Cystoisospora belli, corticosteroid therapy, AIDS, Medicine

الوصف: Cholecystitis is one of the common surgical indications affecting human beings in many countries. A variety of infectious agents can be associated with acute or chronic acalculous cholecystitis, especially in HIV/AIDS patients. In this investigation, the authors aim to describe two cases of histologically and molecularly documented cystoisosporiasis (syn. isosporiasis) as the cause of chronic acalculous cholecystitis in two immunodeficient patients. During microscopic examinations of more than 2500 diarrheic patients’ samples, 11 cases of cystoisosporiasis-related recurrent persistent/chronic diarrhea were detected. A review of the medical records of Cystoisospora belli (syn. Isospora belli)-positive patients showed that two of them, i.e. a patient with prolonged corticosteroid therapy and an AIDS patient, several months prior to fecal examinations had undergone cholecystectomy due to acalculous cholecystitis. The study was continued by a review of the histopathological investigation of the recuts prepared from the excised gallbladder tissue sections and stained with hematoxylin and eosin in order to detect a possible specific clinical correlation with cystoisosporiasis. Light microscopic examination revealed the presence of various developmental stages of a coccidial parasite, namely Cystoisospora belli , in both patients’ gallbladder tissue sections. To the best of our knowledge, C. bellii -associated cholecystitis has not been previously reported in a patient with prolonged corticosteroid therapy.

وصف الملف: electronic resource

العلاقة: https://www.termedia.pl/Cystoisosporiasis-related-human-acalculous-cholecystitis-the-need-for-increased-awareness,55,28764,1,1.htmlTest; https://doaj.org/toc/1233-9687Test; https://doaj.org/toc/2084-9869Test

الوصول الحر: https://doaj.org/article/00b27f95aadb45199183e164ea53df4dTest

المؤلفون: Pawel Bernatowicz, Krzysztof Kowal, Paweł Golec, Pawel Bielecki

المصدر: Advances in Dermatology and Allergology, Vol 37, Iss 1, Pp 61-65 (2020)
Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

مصطلحات موضوعية: medicine.medical_specialty, Cell, Dermatology, cd163, Peripheral blood mononuclear cell, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Immunology and Allergy, Asthmatic patient, Asthma, Original Paper, business.industry, asthma, medicine.disease, RC31-1245, In vitro, medicine.anatomical_structure, Endocrinology, Corticosteroid therapy, induced sputum, RL1-803, inhaled corticosteroids, business, CD163, Ex vivo

الوصف: Introduction The CD163 is exclusively expressed by mononuclear phagocytes as a transmembrane protein, which synthesis is regulated by anti- and pro-inflammatory signals. After shedding from the cell surface it exists in body fluids as a soluble protein (sCD163) which exerts anti-inflammatory effects. Aim To evaluate serum concentration and ex vivo production of sCD163 by peripheral blood mononuclear cells (PBMC) in asthmatic patients treated with inhaled (ICS) or oral corticosteroids (OCS). Material and methods The study was performed on 35 allergic asthma patients (AAs) including 15 treated with ICS (ICS-AAs), 10 with OCS (OCS-AAs), 10 during asthma exacerbation (EX-AAs) before OCS had been started and 13 non-atopic healthy subjects (HCs) as a control group. PBMC were cultured in vitro for up to 144 h. The concentration of sCD163 in serum and the culture supernatants was evaluated with ELISA. Results The greatest serum sCD163 concentration was demonstrated in EX-AAs, which was significantly greater than that in other studied subgroups. The concentration of sCD163 in PBMC culture supernatants was greater in AAs than in HCs (p = 0.006). Among individual asthma subgroups the greatest concentration of sCD163 was demonstrated in PBMC culture supernatants of OCS-AAs, which was significantly greater than in ICS-AAs (p < 0.001) and EX-AAs (p < 0.001), both being significantly greater than in HCs (p < 0.001). Conclusions In AAs, enhanced capability of PBMCs to release sCD163 may be at least partially responsible for the anti-inflammatory effects of systemic corticosteroid therapy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc46b377c5ecc46986f55f036c595e01Test
https://www.termedia.pl/SystemicTest-corticosteroid-therapy-augments-ex-vivo-release-r-nof-sCD163-by-peripheral-blood-monocytes-of-asthmatic-r-npatients,7,40012,1,1.html

المؤلفون: Elżbieta Poniedziałek-Czajkowska, Bożena Leszczyńska-Gorzelak, Radzisław Mierzyński, Jan Oleszczuk

المصدر: Menopause Review, Vol 14, Iss 4, Pp 252-259 (2010)

مصطلحات موضوعية: HELLP syndrome, pathophysiology, diagnosis, corticosteroid therapy, delivery, Medicine

الوصف: The HELLP syndrome is a serious complication of pregnancy characterized by haemolysis, elevated liverenzymes and low platelet count. In the past it was thought to be related to severe preeclampsia, nowadays itis believed to be a separate disease. Its pathogenesis remains to be elucidated – the importance of genetic andimmunological origins is highlighted. This review presents pathogenesis, diagnosis and management in patientswith the HELLP syndrome. About 70% of the cases develop before delivery, the majority between the 24th and37th gestational weeks; the remainder (rest) within 48 hours after delivery. The HELLP syndrome may be completeor incomplete. In the Tennessee Classification System, diagnostic criteria for HELLP are haemolysis with increasedLDH (> 600 U/L), AST (≥ 70 U/L), and platelets < 100 000/mm3. The Mississippi Triple-class HELLP Systemfurther classifies the disorder by the nadir platelet counts. The syndrome is a progressive condition and seriouscomplications are frequent. Delivery is indicated if the HELLP syndrome occurs after the 34th gestational week orthe foetal and/or maternal conditions (status) deteriorate. Conservative treatment (≥ 48 hours) is controversialbut may be considered in selected cases before 34 weeks' gestation. Most authors prefer a single course ofcorticosteroid therapy for RDS prophylaxis between 24th and 34th week of pregnancy. Standard corticosteroidtreatment is still of uncertain clinical value in the management of the maternal HELLP syndrome, but justifiedin some cases, mainly with severe thrombocytopenia. Blood pressure should be kept below 155/105 mm Hgas well as the therapy with MgSO4 should be offered to all patients with the HELLP syndrome.

وصف الملف: electronic resource

العلاقة: http://www.termedia.pl/Zespol-HELLP-patogeneza-i-postepowanie-kliniczne,4,15463,1,0.htmlTest; https://doaj.org/toc/1643-8876Test

الوصول الحر: https://doaj.org/article/7791508b3a884af0820be05251f27ff7Test

المؤلفون: Waldemar Placek, Paweł Krause, Krystyna Romańska-Gocka, Jacek Gocki, Barbara Zegarska

المصدر: Archives of Medical Science : AMS

مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, business.industry, Overlap syndrome, Stevens johnson, Case Report, General Medicine, Clinical manifestation, Carbamazepine, Amoxicillin, medicine.disease, Corticosteroid therapy, medicine, Stevens Johnson syndrome, SJS-TEN overlap syndrome, business, medicine.drug

الوصف: We present a case of Stevens Johnson syndrome in a child after carbamazepine application and Stevens Johnson/TEN overlap syndrome in an adult after amoxicillin application. On the basis of two reported cases we review the most commonly associated drugs, the postulated pathogenesis, clinical manifestation and management in these severe life-threatening diseases. We especially discuss the controversial systemic corticosteroid therapy. Topical care is also discussed.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f683d24380988858cbaa85acb7df37f7Test
http://europepmc.org/articles/PMC3278957Test