التفاصيل البيبلوغرافية
| العنوان: |
Genome-wide association study identifies GYS2 as a novel genetic factor for polycystic ovary syndrome through obesity-related condition. |
| المؤلفون: |
Hwang, Joo-Yeon, Lee, Eun-Ju, Jin Go, Min, Sung, Yeon-Ah, Lee, Hye Jin, Heon Kwak, Soo, Jang, Hak C, Soo Park, Kyung, Lee, Hye-Ja, Byul Jang, Han, Song, Jihyun, Park, Kyung-Hee, Kim, Hyung-Lae, Cho, Myeong-Chan, Lee, Jong-Young |
| المصدر: |
Journal of Human Genetics; Oct2012, Vol. 57 Issue 10, p660-664, 5p, 2 Charts, 1 Graph |
| مصطلحات موضوعية: |
POLYCYSTIC ovary syndrome, GENOMES, OBESITY, ETIOLOGY of diseases, GESTATIONAL diabetes, BODY mass index |
| مستخلص: |
To investigate the role of genetic predisposition in the pathogenesis of polycystic ovary syndrome (PCOS) in relation to obesity, we performed a genome-wide association study of PCOS in Koreans (n=1741). PCOS is a heterogeneous endocrinal disorder of uncertain etiology. Obesity is one of the well-known risk factors for PCOS. Genome-wide association study. Women with or without PCOS. A total of 1881 samples were genotyped using Illumina HumanOmni1 Quad v1 and processed by R packages. The PCOS patients were divided into two subgroups according to PCOS diagnostic criteria (Rotterdam and National Institutes of Health (NIH)). For PCOS-associated loci in the two definitions, we successfully confirmed significant associations of GYS2 for body mass index in the discovery stage. We further replicated pleiotropic associations of GYS2 in a childhood obesity study (n=482) and in a gestational diabetes study (n=1710), respectively. Our study provides a preliminary framework upon diverse genetic effects underlying PCOS in Korean women. A newly identified GYS2 gene as a predisposing factor of PCOS might expand understanding of the biological pathways in metabolic and endocrine regulation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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