دورية أكاديمية
Clinical and electrophysiological follow-up of modafinil treatment for multiple sclerosis patients with fatigue symptom
| العنوان: | Clinical and electrophysiological follow-up of modafinil treatment for multiple sclerosis patients with fatigue symptom |
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| المؤلفون: | AKDOĞAN, Özlem, HAKİ, Cemile, TURAN, Ömer Faruk, TAŞKAPILIOĞLU, Özlem |
| المصدر: | Volume: 6, Issue: 4 326-336 ; 2149-3189 ; The European Research Journal |
| بيانات النشر: | Sağlık Araştırmaları ve Stratejileri Derneği The Association of Health Research and Strategy |
| سنة النشر: | 2020 |
| المجموعة: | DergiPark Akademik (E-Journals) |
| مصطلحات موضوعية: | multiple sclerosis,fatigue,modafinil,evoked potential,fatigue severity scala |
| الوصف: | Objectives: In our study, we investigated the effects of modafinil therapy on clinical and neurophysiological tests of multiple sclerosis (MS) patients with fatigue.Methods: The study was performed on 18 MS patients (16 females, 2 males) at Uludağ University School of Medicine, Department of Neurology, who are followed up according to Mc Donald’s criteria, who had 36 points or above based on the fatigue assesment scala (FAS), whose Beck depression inventory points were 16 and below, whose thyroid, liver and renal functions were evaluated as normal, and who had no systemic disorder. All patients had neurological examination and their expanded disability status scale (EDSS), fatigue impact scala (FIS) and multiple sclerosis quality of life (MSQoL-54) were evaluated. Somatosensory evoked potential (SEP), visual evoked potential (VEP), brainstem auditory evoked potential (BAEP), visual event related evoked potential (visual P300) were performed in our neurophysiology laboratory. After that the patients were given modafinil 100 mgr 1×1 (morning) for 1 week, the following weeks 2×1 (morning and noon). At the end of the 6 weeks of therapy the patients were called to the neurology polyclinic, and their neurological examinations, EDSS, FIS, MSQoL-54, SEP, VEP, BAEP and visual P300 were repeated.Results: When the patients’ previous and subsequent FIS and MSQoL-54 total scores were compared, a significant statistical difference was found. When all 3 subgroups of FIS (consciousness, physical and social) were evaluated after the modafinil therapy, a significant statistical decrease in previous and successive scores were found. It is found out that modafinil therapy improves life quality which is evaluated due to MSQoL-54 (p < 0.05). A significant statistical relation between the number of MS disease attacks and the three subgroups of MFIS was not figured out (p > 0.05). There were no statistically significant relation between the FAS, EDSS and Beck depression inventory scores before the modafinil therapy had ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://dergipark.org.tr/tr/download/article-file/814051Test; https://dergipark.org.tr/tr/pub/eurj/issue/54320/493073Test |
| DOI: | 10.18621/eurj.493073 |
| الإتاحة: | https://doi.org/10.18621/eurj.493073Test https://dergipark.org.tr/tr/pub/eurj/issue/54320/493073Test |
| رقم الانضمام: | edsbas.1775E488 |
| قاعدة البيانات: | BASE |
| DOI: | 10.18621/eurj.493073 |
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