دورية أكاديمية
Unmet Needs and Perspectives in Oral Cancer Prevention
| العنوان: | Unmet Needs and Perspectives in Oral Cancer Prevention |
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| المؤلفون: | Bouaoud, Jebrane, Bossi, Paolo, Elkabets, Moshe, Schmitz, Sandra, van Kempen, Leon C, Martinez, Pierre, Jagadeeshan, Sankar, Breuskin, Ingrid, Puppels, Gerwin J, Hoffmann, Caroline, Hunter, Keith D, Simon, Christian, Machiels, Jean-Pascal, Gregoire, Vincent, Bertolus, Chloe, Brakenhoff, Ruud H, Koljenovic, Senada, Saintigny, Pierre |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2022 |
| المجموعة: | The University of Liverpool Repository |
| الوصف: | Oral potentially malignant disorders (OPMD) may precede oral squamous cell carcinoma (OSCC). Reported rates of malignant transformation of OPMD range from 3 to 50%. While some clinical, histological, and molecular factors have been associated with a high-risk OPMD, they are, to date, insufficiently accurate for treatment decision-making. Moreover, this range highlights differences in the clinical definition of OPMD, variation in follow-up periods, and molecular and biological heterogeneity of OPMD. Finally, while treatment of OPMD may improve outcome, standard therapy has been shown to be ineffective to prevent OSCC development in patients with OPMD. In this perspective paper, several experts discuss the main challenges in oral cancer prevention, in particular the need to (i) to define an OPMD classification system by integrating new pathological and molecular characteristics, aiming (ii) to better identify OPMD at high risk of malignant transformation, and (iii) to develop treatment strategies to eradicate OPMD or prevent malignant transformation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | Collapse authors list. Bouaoud, Jebrane, Bossi, Paolo, Elkabets, Moshe, Schmitz, Sandra, van Kempen, Leon C, Martinez, Pierre, Jagadeeshan, Sankar, Breuskin, Ingrid, Puppels, Gerwin J, Hoffmann, Caroline et al (show 8 more authors) , Hunter, Keith D orcid:0000-0002-7873-0877 , Simon, Christian, Machiels, Jean-Pascal, Gregoire, Vincent, Bertolus, Chloe, Brakenhoff, Ruud H, Koljenovic, Senada and Saintigny, Pierre (2022) Unmet Needs and Perspectives in Oral Cancer Prevention. CANCERS, 14 (7). 1815-. |
| DOI: | 10.3390/cancers14071815 |
| الإتاحة: | https://doi.org/10.3390/cancers14071815Test http://livrepository.liverpool.ac.uk/3155455Test/ |
| رقم الانضمام: | edsbas.63CEB48A |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cancers14071815 |
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