التفاصيل البيبلوغرافية
| العنوان: |
Isavuconazole Treatment of Spinal Cord Invasive Aspergillosis Guided by Cerebrospinal Fluid (1,3)-β-d-Glucan Levels in a Patient with Low Interferon-Gamma and Ulcerative Colitis. |
| المؤلفون: |
O'Regan, Siobhan, O'Kelly, Brendan, Reidy, Paul, O'Toole, Aoibhlinn, Caird, John, McNally, Cora, McConkey, Samuel, de Barra, Eoghan |
| المصدر: |
Journal of Fungi; Jun2022, Vol. 8 Issue 6, p557, 7p |
| مصطلحات موضوعية: |
ULCERATIVE colitis, SPINAL cord, ASPERGILLOSIS, INTERFERON gamma, CERVICAL cord, PULMONARY aspergillosis, NEUROSURGERY, CEREBROSPINAL fluid |
| مستخلص: |
This case highlights the use of (1,3)-beta-d glucan to direct treatment of a cervical spinal cord Aspergillus fumigatus infection in a 22-year-old woman immunocompromised due to steroid and anti-TNF therapy in the context of ulcerative colitis and interferon gamma deficiency. A 4-year treatment course requiring neurosurgical intervention on four occasions and prolonged antifungal therapy, including isavuconazole, resulted in clinical cure with a corresponding decrease in CSF beta-d-glucan to <30 pg/mL. Serum and CSF galactomannan levels were not elevated at any point during the clinical course. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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