دورية أكاديمية
Subclinical Hypothyroidism has Little Influences on Muscle Mass or Strength in Elderly People
| العنوان: | Subclinical Hypothyroidism has Little Influences on Muscle Mass or Strength in Elderly People |
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| المؤلفون: | Moon, Min Kyong, Lee, You Jin, Choi, Sung Hee, Lim, Soo, Lim, Jae-Young, Kim, Ki Woong, Jang, Hak C., Park, Young Joo, Cho, Bo Youn, Park, Kyong Soo, Paik, Nam-Jong, Yang, Eun Joo |
| المساهمون: | 문민경, 이유진, 최성희, 임수, 양은주, 임재영, 백남종, 김기웅, 박경수, 조보연, 박영주 |
| بيانات النشر: | KOREAN ACAD MEDICAL SCIENCES |
| سنة النشر: | 2010 |
| المجموعة: | Seoul National University: S-Space |
| مصطلحات موضوعية: | Sarcopenia, Aged, Subclinical Hypothyroidism |
| الوصف: | Sarcopenia, the age-related decline in muscle mass, affects the muscle strength and muscle quality, and these changes decrease functional capacity. The prevalence of thyroid dysfunction increases with age, and changes in thyroid hormone level lead to neuromuscular deficits. We investigated the effects of subclinical hypothyroidism on the muscle mass, strength or quality in elderly people. One thousand one hundred eighteen subjects aged >= 65 yr were randomly selected from a local population and classified into a euthyroid (280 men and 358 women), subclinically hypothyroid (61 men and 75 women), or overtly hypothyroid (7 men and 16 women) group. Although women with subclinical hypothyroidism had a higher prevalence of sarcopenia, defined according to the ratio of appendicular skeletal muscle mass to the square of height, muscle mass, strength or quality did not differ in relation to thyroid status in men or in women. Multivariate analysis including age, diabetes, hypertension, acute coronary event, alcohol, smoking, presence of pain, physical activity score, and lipid profile, showed that thyroid-stimulating hormone level was not associated with muscle mass, strength or quality. In conclusion, subclinical hypothyroidism has little influences on muscle mass, strength or quality, and may not be associated with sarcopenia. ; This work was supported by a grant (M10642140004-06N4214- 00410) from the Korea Science and Engineering Foundation (KOSEF), the Ministry of Education, Science and Technology, Korea. ; Pua YH, 2009, J CLIN EPIDEMIOL, V62, P1103, DOI 10.1016/j.jclinepi.2008.11.011 ; Celik B, 2008, INT J REHABIL RES, V31, P93 ; Hansen RD, 2007, AM J CLIN NUTR, V86, P952 ; PARK JH, 2007, PSYCHIAT INVEST, V4, P84 ; *AM DIAB ASS, 2007, DIABETES CARE S1, V30, pS42, DOI DOI 10.2337/DC07-S042 ; Brennan MD, 2006, THYROID, V16, P375 ; Newman AB, 2006, J GERONTOL A-BIOL, V61, P72 ; O`Leary PC, 2006, CLIN ENDOCRINOL, V64, P97, DOI 10.1111/j.1365-2265.2005.02424.x ; Doherty TJ, 2003, J APPL PHYSIOL, V95, P1717, DOI ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1011-8934 |
| العلاقة: | JOURNAL OF KOREAN MEDICAL SCIENCE; Vol.25 8; 1176-1181; http://hdl.handle.net/10371/76474Test |
| DOI: | 10.3346/jkms.2010.25.8.1176 |
| الإتاحة: | https://doi.org/10.3346/jkms.2010.25.8.1176Test http://hdl.handle.net/10371/76474Test |
| رقم الانضمام: | edsbas.AAB988E |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10118934 |
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| DOI: | 10.3346/jkms.2010.25.8.1176 |