Cell signaling pathways elicited by asbestos
| العنوان: | Cell signaling pathways elicited by asbestos |
|---|---|
| المؤلفون: | Kevin E. Driscoll, Cynthia R. Timblin, Aaron Barchowsky, Yvonne M. W. Janssen, Christine L. Zanella, Steven Faux, Jonathan Goldberg, Luis A. Jimenez, Brooke T. Mossman, Eric S. Walsh |
| المصدر: | Environmental Health Perspectives |
| بيانات النشر: | Environmental Health Perspectives, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | MAPK/ERK pathway, Cell signaling, Health, Toxicology and Mutagenesis, Cell Communication, Biology, Cell Line, Transactivation, Cricetinae, Gene expression, Animals, Transcription factor, Activator (genetics), Asbestos, Crocidolite, NF-kappa B, Public Health, Environmental and Occupational Health, Asbestos, Epithelial Cells, NFKB1, Cell biology, ErbB Receptors, Transcription Factor AP-1, Phenotype, Calcium-Calmodulin-Dependent Protein Kinases, Carcinogens, Electrophoresis, Polyacrylamide Gel, Signal transduction, Cell Division, Signal Transduction, Research Article |
| الوصف: | In recent years, it has become apparent that minerals can trigger alterations in gene expression by initiating signaling events upstream of gene transactivation. These cascades may be initiated at the cell surface after interaction of minerals with the plasma membrane either through receptorlike mechanisms or integrins. Alternatively, signaling pathways may be stimulated by active oxygen species generated both during phagocytosis of minerals and by redox reactions on the mineral surface. At least two signaling cascades linked to activation of transcription factors, i.e., DNA-binding proteins involved in modulating gene expression and DNA replication, are stimulated after exposure of lung cells to asbestos fibers in vitro. These include nuclear factor kappa B (NF kappa B) and the mitogen-activated protein kinase (MAPK) cascade important in regulation of the transcription factor, activator protein-1 (AP-1). Both NF kappa B and AP-1 bind to specific DNA sequences within the regulatory or promoter regions of genes that are critical to cell proliferation and inflammation. Unraveling the cell signaling cascades initiated by mineral dusts and pharmacologic inhibition of these events may be important for the control and treatment of mineral-associated occupational diseases. Images Figure 2. B Figure 3. A Figure 3. B |
| تدمد: | 1552-9924 0091-6765 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17d6d01bd90f1e140d1cb11415f1ab89Test https://doi.org/10.1289/ehp.97105s51121Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....17d6d01bd90f1e140d1cb11415f1ab89 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15529924 00916765 |
|---|