نتائج البحث - "NASH non-alcoholic steatohepatitis"

1

Risk of further decompensation/mortality in patients with cirrhosis and ascites as the first single decompensation event

المؤلفون: Lorenz Balcar, Marta Tonon, Georg Semmler, Valeria Calvino, Lukas Hartl, Simone Incicco, Mathias Jachs, David Bauer, Benedikt Silvester Hofer, Carmine Gabriele Gambino, Antonio Accetta, Alessandra Brocca, Michael Trauner, Mattias Mandorfer, Salvatore Piano, Thomas Reiberger

المصدر: JHEP Reports. 4:100513

مصطلحات موضوعية: PVT, HE, international normalised ratio, Child–Pugh score, SHR, United Network for Organ Sharing model for end-stage liver disease (2016), LT, ACLF, Immunology and Allergy, model for end-stage liver disease, portal vein thrombosis, aSHR, HCC, Portal hypertension, TFS, Baveno, UNOS MELD (2016), liver transplantation, IQR, NASH, Gastroenterology, CI, hepatocellular carcinoma, Acute kidney injury, TIPS, non-alcoholic steatohepatitis, acute-on-chronic liver failure, Hepatic decompensation, INR, adjusted subdistribution hazard ratio, interquartile range, hepatic encephalopathy, HRS-AKI, NAFLD, transjugular intrahepatic portosystemic shunt, Internal Medicine, Spontaneous bacterial peritonitis, subdistribution hazard ratio, ICA, SBP, variceal bleeding, refractory ascites, Hepatology, ACLF, acute-on-chronic liver failure, CI, confidence interval, CPS, Child–Pugh score, HCC, hepatocellular carcinoma, HE, hepatic encephalopathy, HRS-AKI, hepatorenal syndrome–acute kidney injury, ICA, International Club of Ascites, INR, international normalised ratio, IQR, interquartile range, LT, liver transplantation, MELD, model for end-stage liver disease, NAFLD, non-alcoholic fatty liver disease, NASH, non-alcoholic steatohepatitis, PVT, portal vein thrombosis, RA, refractory ascites, SBP, spontaneous bacterial peritonitis, SHR, subdistribution hazard ratio, TFS, transplant-free survival, TIPS, transjugular intrahepatic portosystemic shunt, UNOS MELD (2016), United Network for Organ Sharing model for end-stage liver disease (2016), VB, variceal bleeding, aSHR, adjusted subdistribution hazard ratio, non-alcoholic fatty liver disease, transplant-free survival, MELD, VB, confidence interval, International Club of Ascites, hepatorenal syndrome–acute kidney injury, CPS, RA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf81a5f893918c40914501beaf552554Test
https://doi.org/10.1016/j.jhepr.2022.100513Test

2

Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators

المؤلفون: Mirella Pastore, Alessandra Caligiuri, Chiara Raggi, Nadia Navari, Benedetta Piombanti, Giovanni Di Maira, Elisabetta Rovida, Marie-Pierre Piccinni, Letizia Lombardelli, Federica Logiodice, Krista Rombouts, Salvatore Petta, Fabio Marra

المساهمون: Pastore, Mirella, Caligiuri, Alessandra, Raggi, Chiara, Navari, Nadia, Piombanti, Benedetta, Di Maira, Giovanni, Rovida, Elisabetta, Piccinni, Marie-Pierre, Lombardelli, Letizia, Logiodice, Federica, Rombouts, Krista, Petta, Salvatore, Marra, Fabio

المصدر: JHEP Reports. 4:100444

مصطلحات موضوعية: Hepatology, CM, conditioned medium, ECM, extracellular matrix, Gas-6, Gas-6, growth arrest-specific gene 6, HSC(s), hepatic stellate cells, KC(s), Kupffer cell(s), M-CSF, macrophage colony-stimulating factor, M2c-like macrophages, MerTK, Myeloid-epithelial-reproductive tyrosine kinase, NAFLD, non-alcoholic fatty liver disease, NASH, NASH, non-alcoholic steatohepatitis, PMA, phorbol 12-myristate 13-acetate, TGFβ1, transforming growth factor-β1, THP-1, TIMP1, tissue inhibitor of metalloproteinase 1, VEGF-A, vascular endothelial growth factor-A, liver fibrosis, siRNA, small-interfering RNA, Gas-6, liver fibrosis, M2c-like macrophages, NASH, THP-1, Gastroenterology, Internal Medicine, Immunology and Allergy

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4426fd2abba675fb27730b5800bb5ccTest
https://doi.org/10.1016/j.jhepr.2022.100444Test

3

ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis

المؤلفون: Bruce R. Blazar, Gregory Miller, Wei Chen, Jing Liu, Melanie S. Nyuydzefe, Geoffrey R. Hill, Katharine M. Irvine, Michelle Melino, Wayne A. Schroder, Patrick Bertolino, Kelli P. A. MacDonald, Alexandra Zanin-Zhorov, Michele W.L. Teng, Christina Nalkurthi, Andrew D. Clouston

المصدر: JHEP Reports

مصطلحات موضوعية: pSTAT3, phosphorylated signal transducer and activator of transcription, STAT3, signal transducer and activator of transcription 3, medicine.medical_treatment, AST, aspartate aminotransferase, TGF-β, transforming growth factor-beta, Chronic liver disease, TNF, tumour necrosis factor, RORγt, RAR-related orphan receptor gamma, Fibrosis, Th17, T helper 17, Immunology and Allergy, Macrophage, BMDM, bone marrow-derived macrophages, pCofilin, phosphorylated cofilin, Gastroenterology, qRT-PCR, quantitative real-time PCR, HSC, hepatic stellate cell, ECM, extracellular matrix, MMP, matrix metalloproteinase, IL-17, Cytokine, LPS, lipopolysaccharide, medicine.symptom, GC, germinal centre, ROCK2, Rho-associated kinase 2, Research Article, ROCK2 Inhibitor KD025, NASH, non-alcoholic steatohepatitis, Liver fibrosis, α-SMA, alpha smooth muscle actin, IHC, immunohistochemical, Tfh, T follicular helper, Inflammation, Col1a2, collagen type α1, Bcl6, B-cell lymphoma 6, ROCK2, Immune system, ALT, alanine aminotransferase, Internal Medicine, medicine, DR, ductular reaction, B cells, cGVHD, chronic graft-vs-host disease, pMac, peritoneal macrophages, TAA, thioacetamide, Hepatology, business.industry, Macrophages, SR, Sirius red, medicine.disease, ROCK, Rho-associated coiled-coil forming protein kinases, RAR, retinoic acid receptor, CLD, chronic liver disease, Cancer research, Therapy, HCC, hepatocellular carcinoma, business, Hepatic fibrosis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d909aee919cee8dee5b9a4e06674119fTest
https://doi.org/10.1016/j.jhepr.2021.100386Test

4

Monocyte dysfunction in decompensated cirrhosis is mediated by the prostaglandin E2-EP4 pathway

المؤلفون: Louise China, Nekisa Zakeri, Tu Vinh Long, Alexander A. Maini, Amit Patel, Thais Helena Tittanegro, Alastair O'Brien, Roel P.H. De Maeyer, Natalia Becares, Derek W. Gilroy, Lucy Ly

المصدر: JHEP Reports, Vol 3, Iss 6, Pp 100332-(2021)
JHEP Reports

مصطلحات موضوعية: Cirrhosis, TNF, Decompensated cirrhosis, RC799-869, cPGES, cytosolic PGE synthase, HPGD, 15-hydroxyprostaglandin dehydrogenase, Gastroenterology, Liver disease, MDMs, monocyte-derived macrophages, Microsomal PGE synthase 1, Ascites, LC-MS/MS, liquid chromatography-tandem mass spectrometry, CM, classical monocytes, Immunology and Allergy, MFI, mean fluorescence intensity, TNFα, tumour necrosis factor alpha, Whole blood, TIPS, transjugular intrahepatic portosystemic shunt insertion, EIA, enzyme immune assay, HLA DR, human leukocyte antigen – DR isotype, Diseases of the digestive system. Gastroenterology, Jaundice, sCD14, soluble CD14, medicine.anatomical_structure, CRP, C-reactive protein, LPS, lipopolysaccharide, lipids (amino acids, peptides, and proteins), medicine.symptom, Research Article, HVs, healthy volunteers, medicine.medical_specialty, LPS, CAID, cirrhosis-associated immune dysfunction, NASH, non-alcoholic steatohepatitis, mPGES1, microsomal PGE synthase 1, Cyclo-oxygenase 1, White blood cell, Internal medicine, PGE2, prostaglandin E2, Internal Medicine, medicine, Decompensation, FACS, polychromatic flow cytometric analysis, Hepatology, business.industry, Monocyte, HLA-DR, OPD, patients with refractory ascites attending hospital outpatient department for day case paracentesis, DSS, downstream synthases, medicine.disease, AD, acute decompensation, IL6, COX, cyclooxygenase, ACLF, acute-on-chronic liver failure, qPCR, quantitative PCR, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3389d2aeb9a6d0bb948f1425e23e31fcTest
https://doi.org/10.1016/j.jhepr.2021.100332Test

5

Case-finding strategies in non-alcoholic fatty liver disease

المؤلفون: Jérôme Boursier, Emmanuel Tsochatzis

المساهمون: Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)

المصدر: JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (2), pp.100219. ⟨10.1016/j.jhepr.2020.100219⟩
JHEP Reports

مصطلحات موضوعية: Cirrhosis, Cost effectiveness, [SDV]Life Sciences [q-bio], NICE, National Institute of Clinical Excellence, Nice, Review, AST, aspartate aminotransferase, Disease, Patient pathway, ELF, enhanced liver fibrosis, 0302 clinical medicine, Immunology and Allergy, Medicine, NFS, NAFLD fibrosis score, ALD, alcohol-related liver disease, ComputingMilieux_MISCELLANEOUS, computer.programming_language, 0303 health sciences, NAS, NAFLD activity score, Case-finding, Fatty liver, Gastroenterology, Awareness, Primary care, TE, transient elastography, 3. Good health, Screening, FIB-4, 030211 gastroenterology & hepatology, Elastography, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, NASH, non-alcoholic steatohepatitis, Liver fibrosis, QALY, quality-adjusted life year, 03 medical and health sciences, ALT, alanine aminotransferase, Type 2 diabetes mellitus, NIT, non-invasive test, Internal Medicine, GP, general practitioner, FIB-4, fibrosis-4, Intensive care medicine, 030304 developmental biology, Hepatology, business.industry, Type 2 Diabetes Mellitus, T2DM, type 2 diabetes mellitus, medicine.disease, Quality-adjusted life year, Cost-effectiveness, Transient elastography, business, computer