المؤلفون: Carrie E. McCurdy, Kenneth N. Maclean, Paul Kievit, Bryan C. Bergman, Rachel C. Janssen, Peter R. Baker, Christopher M. Mulligan, Tyler Dean, Diana L. Takahashi, Travis Nemkov, Kjersti Aagaard, Hua Jiang, Stephanie R. Wesolowski, Angelo D'Alessandro, Jacob E. Friedman

المصدر: Molecular Metabolism, Vol 18, Iss, Pp 25-41 (2018)
Molecular Metabolism

مصطلحات موضوعية: 0301 basic medicine, Steatosis, VIP, variable importance in projection, Hypoxemia, AUC, area under the curve, PC, phosphatidylcholine, 0302 clinical medicine, WSD, Western-style diet, Non-alcoholic Fatty Liver Disease, Pregnancy, Fetal programming, Hyperlipidemia, DAG, diacylglyceride, VLDL, very low-density lipoprotein, Hypoxia, 2. Zero hunger, TG, triglyceride, NEFA, non-esterified fatty acid, NHP, non-human primate, Fatty liver, 3. Good health, Liver, Lipotoxicity, CON, control, OB-WSD, Western-style diet induced obesity group, IV-GTT, intravenous glucose tolerance test, Prenatal Exposure Delayed Effects, Original Article, Female, Diet, Healthy, PLS-DA, partial least squares discriminant analysis, TCA, tricarboxylic acid cycle, NAFLD, non-alcoholic fatty liver disease, lcsh:Internal medicine, medicine.medical_specialty, Offspring, NASH, non-alcoholic steatohepatitis, Citric Acid Cycle, Metabolomic, 030209 endocrinology & metabolism, DNL, de novo lipogenesis, TBARs, thiobarbituric acid reactive substances, OB-DR, diet reversal group, 03 medical and health sciences, Fetus, Internal medicine, medicine, TBARS, Animals, Obesity, AA, amino acid, lcsh:RC31-1245, Molecular Biology, Triglycerides, business.industry, Gluconeogenesis, Maternal Nutritional Physiological Phenomena, Cell Biology, medicine.disease, Oxidative Stress, 030104 developmental biology, Endocrinology, Diet, Western, Macaca, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06dccd8288a52f01636dbe7fd72ba0fTest
https://doi.org/10.1016/j.molmet.2018.09.008Test

المؤلفون: Kathrin van Bremen, Christoph Boesecke, Jenny Bischoff, Carolynne Schwarze-Zander, Wenyi Gu, Jan-Christian Wasmuth, Jonel Trebicka, Leona Dold, Jürgen K. Rockstroh

المصدر: EClinicalMedicine, Vol 40, Iss, Pp 101116-(2021)
EClinicalMedicine
E Clinical Medicine part of the LANCET Discovery Science

مصطلحات موضوعية: Medicine (General), medicine.medical_specialty, Steatosis, TAF, tenofovir-alafenamid, BMI, body mass index, NASH, non-alcoholic steatohepatitis, FIB4, fibrosis-4, cART, AST, aspartate aminotransferase, APRI, AST to platelet ratio index, INSTI, integrase strand transfer inhibitors, TDF, Tenofovir disoproxilfumarate, Lower risk, PrEP, pre-exposure prophylaxis, Pre-exposure prophylaxis, R5-920, Internal medicine, medicine, PLHIV, people living with HIV, FAST, FibroScan-AST, Nafld, business.industry, Proportional hazards model, Fatty liver, Hiv, DAA, direct-acting antiviral, NAFLD, Non-alcoholic fatty liver disease, General Medicine, medicine.disease, Cap, Comorbidity, TE, transient elastography, CAP, controlled attenuation parameter, HCV, chronic hepatitis C, Transient elastography, business, Body mass index, ART, antiretroviral treatment, Research Paper

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c309e13de16a72b2c91a8b35344a42Test
https://doi.org/10.1016/j.eclinm.2021.101116Test

المؤلفون: Thomas Laeger, Louise Fritsche, Christian Baumeier, Norbert Stefan, Annette Schürmann, Sophie Saussenthaler, Andreas Fritsche, Robert W. Schwenk, Maria Rödiger, Hans-Ulrich Häring, Luisa Schlüter, Stella Amelie Alaze

المصدر: Molecular Metabolism
Mol. Metab. 6, 1254-1263 (2017)
Molecular Metabolism, Vol 6, Iss 10, Pp 1254-1263 (2017)

مصطلحات موضوعية: 0301 basic medicine, Male, HFD, high-fat diet, PPARγ, medicine.medical_treatment, CD36, Adipose tissue, AST, aspartate aminotransferase, SM, skeletal muscle, Mice, F4/80, adhesion G protein-coupled receptor E1, GGT, gamma-glutamyl transpeptidase, Non-alcoholic Fatty Liver Disease, Insulin, rmDPP4, recombinant mouse dipeptidyl peptidase 4, rhDPP4, recombinant human dipeptidyl peptidase 4, Fatty liver, Ad, adenovirus, sWAT, subcutaneous white adipose tissue, Hep G2 Cells, Middle Aged, Dgat2, diacylglycerol O-acyltransferase 2, Cd36, Dpp4, Glp-1, Insulin Resistance, Nafld, Pparγ, TNFα, tumor necrosis factor α, Liver, Cpt1a, carnitine palmitoyltransferase 1a, MOGAT1, monoacylglycerol O-acyltransferase 1, Original Article, Female, medicine.symptom, PPARγ, peroxisome proliferator activated receptor gamma, Dpp4-Liv-Tg, transgenic mice with hepatocyte-specific Dpp4 overexpression, NFκB, nuclear factor-κB, Adult, lcsh:Internal medicine, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, Akt, Akt serine–threonine protein kinase, HOMA-IR, homeostatic model assessment for insulin resistance, IL6, interleukin 6, NASH, non-alcoholic steatohepatitis, Dipeptidyl Peptidase 4, gWAT, gonadal white adipose tissue, Inflammation, Srebf1, sterol regulatory element binding transcription factor 1, Mice, Transgenic, Biology, DPP4, 03 medical and health sciences, Insulin resistance, Internal medicine, NAFLD, ALT, alanine aminotransferase, medicine, Animals, Humans, ApoB, apolipoprotein B, GLP-1, glucagon-like peptide 1, Obesity, lcsh:RC31-1245, Molecular Biology, pAkt, phosphorylated Akt serine–threonine protein kinase, Cell Biology, medicine.disease, CD36, fatty acid translocase, DPP4, dipeptidyl peptidase 4, WT, wild-type, BAT, brown adipose tissue, Insulin receptor, Disease Models, Animal, 030104 developmental biology, Endocrinology, biology.protein, Hepatocytes, Gfp, green fluorescent protein, Steatosis, GLP-1, MCP1, chemokine (C-C motif) ligand 2, MAPK, mitogen-activated protein kinase

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec108ccaaae2e081b54e4ea79fe8b459Test

المؤلفون: Anika Nier, Ina Bergheim, Amélia Camarinha-Silva, Cheng Jun Jin, Annette Brandt, Anja Baumann, Angélica Hernández-Arriaga, Dragana Rajcic, Victor Sánchez, Finn Jung

المصدر: Redox Biology
Redox Biology, Vol 41, Iss, Pp 101879-(2021)

مصطلحات موضوعية: 0301 basic medicine, Medicine (General), F, fructose, Arginine, Clinical Biochemistry, AST, aspartate aminotransferase, Biochemistry, Mice, AUC, area under the curve, NOHA, N(ω)-hydroxy-nor-l-arginine, Liver disease, chemistry.chemical_compound, PCR, polymerase chain reaction, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, ARG2, arginase 2, 3-NT, 3-nitrotyrosine, Citrulline, Biology (General), NAS, NAFLD activity score, Fatty liver, FFC, fat-, fructose- and cholesterol-rich diet, L-Cit, l-citrulline, Arginase, medicine.anatomical_structure, Liver, iNOS, inducible nitric oxide synthase, Female, Research Paper, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, QH301-705.5, C, control diet, NASH, non-alcoholic steatohepatitis, TNFα, tumor necrosis factor alpha, Intestinal permeability, Diet, High-Fat, SEM, standard error of the mean, NO, 03 medical and health sciences, R5-920, Tlr4, toll-like receptor 4, 4-HNE, 4-hydroxynonenal, ALT, alanine aminotransferase, Internal medicine, medicine, Animals, Hepatic inflammation, Gpr41, G-protein-coupled receptor 41, NO, nitric oxide, business.industry, Bacterial endotoxin, Organic Chemistry, E%, percentage of energy, medicine.disease, ZO-1, zonula occludens 1, Small intestine, GTT, glucose-tolerance-test, Mice, Inbred C57BL, Toll-Like Receptor 4, 030104 developmental biology, Endocrinology, chemistry, Dietary Supplements, Myd88, myeloid differentiation primary response 88, Gpr43, G-protein-coupled receptor 43, Steatohepatitis, business, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c29ebb68a39a4a69ad56089e73e70eTest
https://doi.org/10.1016/j.redox.2021.101879Test

المؤلفون: Jérôme Boursier, Emmanuel Tsochatzis

المساهمون: Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)

المصدر: JHEP Reports Innovation in Hepatology
JHEP Reports Innovation in Hepatology, Elsevier, 2021, 3 (2), pp.100219. ⟨10.1016/j.jhepr.2020.100219⟩
JHEP Reports

مصطلحات موضوعية: Cirrhosis, Cost effectiveness, [SDV]Life Sciences [q-bio], NICE, National Institute of Clinical Excellence, Nice, Review, AST, aspartate aminotransferase, Disease, Patient pathway, ELF, enhanced liver fibrosis, 0302 clinical medicine, Immunology and Allergy, Medicine, NFS, NAFLD fibrosis score, ALD, alcohol-related liver disease, ComputingMilieux_MISCELLANEOUS, computer.programming_language, 0303 health sciences, NAS, NAFLD activity score, Case-finding, Fatty liver, Gastroenterology, Awareness, Primary care, TE, transient elastography, 3. Good health, Screening, FIB-4, 030211 gastroenterology & hepatology, Elastography, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, NASH, non-alcoholic steatohepatitis, Liver fibrosis, QALY, quality-adjusted life year, 03 medical and health sciences, ALT, alanine aminotransferase, Type 2 diabetes mellitus, NIT, non-invasive test, Internal Medicine, GP, general practitioner, FIB-4, fibrosis-4, Intensive care medicine, 030304 developmental biology, Hepatology, business.industry, Type 2 Diabetes Mellitus, T2DM, type 2 diabetes mellitus, medicine.disease, Quality-adjusted life year, Cost-effectiveness, Transient elastography, business, computer

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998a5dc5ae8854bb83716af6e6873dc7Test
https://doi.org/10.1016/j.jhepr.2020.100219Test

المؤلفون: Taesik Gwag, Shuxia Wang, Eun Y. Lee, Dong Li, Raja Gopal Reddy Mooli, Sangderk Lee

المصدر: JHEP Reports
JHEP Reports, Vol 3, Iss 1, Pp 100193-(2021)

مصطلحات موضوعية: HFD, high-fat diet, Cirrhosis, Th, T helper type, Macrophage, AST, aspartate aminotransferase, Chronic liver disease, α-SMA, smooth muscle actin, TNF, tumour necrosis factor, TSP1, TSP1, thrombospondin 1, DEG, differentially expressed gene, IL-, interleukin, Immunology and Allergy, Medicine, TGF, transforming growth factor, scRNA-seq, single-cell RNA sequencing, Liver injury, NAS, NAFLD activity score, Fatty liver, NASH, SMPDL3B, Gastroenterology, AMLN, amylin liver NASH, ASMase, acid sphingomyelinase, BMDM, bone marrow-derived macrophage, HSC, hepatic stellate cell, ECM, extracellular matrix, SMPDL3B, sphingomyelin phosphodiesterase acid-like 3B, LPS, lipopolysaccharide, Research Article, TLR, Toll-like receptor, GPI, glycosylphosphatidylinositol, NAFLD, non-alcoholic fatty liver disease, NASH, non-alcoholic steatohepatitis, NF-κB, nuclear factor-κB, KEGG, Kyoto Encyclopedia of Genes and Genomes, MP, mononuclear phagocyte, digestive system, Tsp1Δmɸ, macrophage-specific TSP1-knockout mice, Insulin resistance, NAFLD, ALT, alanine aminotransferase, Internal Medicine, KC, Kupffer cell, Tsp1Δadipo, adipocyte-specific TSP1-knockout mice, Obesity, lcsh:RC799-869, Hepatology, EC, endothelial cell, business.industry, nutritional and metabolic diseases, medicine.disease, digestive system diseases, LFD, low-fat diet, SREBP1c, sterol regulatory element-binding protein-1 c, Cancer research, Hepatic stellate cell, Tsp1fl/fl, TSP1 floxed mice, lcsh:Diseases of the digestive system. Gastroenterology, MDM, monocyte-derived macrophage, qPCR, quantitative PCR, Steatosis, Steatohepatitis, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063dac1179b4deacdbae7ecdef605114Test
https://doi.org/10.1016/j.jhepr.2020.100193Test

المؤلفون: Mattias Ekstedt, Jennifer Linge, Olof Dahlqvist Leinhard

المصدر: JHEP Reports, Vol 3, Iss 1, Pp 100197-(2021)
JHEP Reports

مصطلحات موضوعية: Sarcopenia, Myosteatosis, Skeletal muscle, AMC, Type 2 diabetes, CHD, coronary heart disease, Grip strength, Liver disease, Diabetes mellitus, FFMV, fat-tissue free muscle volume, non-alcoholic steatohepatitis, Non-alcoholic steatohepatitis, PDFF, PDFF, proton density fat fraction, Immunology and Allergy, Fatty liver, coronary heart disease, Cardiovascular disease, DXA, Gastroenterology, muscle fat infiltration, Magnetic resonance imaging, NAFLD, proton density fat fraction, T2D, medicine.anatomical_structure, fat-tissue free muscle volume, FIB-4, fibrosis-4, HbA1c, Research Article, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, NASH, non-alcoholic steatohepatitis, dual-energy x-ray absorptiometry, FFMV, T2D, type 2 diabetes, Gastroenterology and Hepatology, MFI, muscle fat infiltration, DXA, dual-energy x-ray absorptiometry, glycated haemoglobin, MFI, virtual control group, Internal medicine, Gastroenterologi, Internal Medicine, medicine, VCG, virtual control group, FIB-4, fibrosis-4, lcsh:RC799-869, adverse muscle composition, CHD, Hepatology, business.industry, medicine.disease, Comorbidity, non-alcoholic fatty liver disease, NASH, AMC, adverse muscle composition, HbA1c, glycated haemoglobin, lcsh:Diseases of the digestive system. Gastroenterology, type 2 diabetes, VCG, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64b7d5e87e73ceb0598021536bc3699Test
https://doi.org/10.1016/j.jhepr.2020.100197Test

المؤلفون: Mayumi Nagashimada, Eric Mayoux, Naoto Nagata, Guanliang Chen, Liang Xu, Shuichi Kaneko, Yinhua Ni, Fen Zhuge, Tsuguhito Ota

المصدر: EBioMedicine
EBioMedicine, Vol 20, Iss C, Pp 137-149 (2017)

مصطلحات موضوعية: Male, 0301 basic medicine, HFD, high-fat diet, FGF21, Macrophage, lcsh:Medicine, AST, aspartate aminotransferase, White adipose tissue, 030204 cardiovascular system & hematology, ATMs, adipose tissue macrophages, Brown adipose tissue, EGP, endogenous glucose production, Mice, 0302 clinical medicine, Glucosides, FACS, fluorescence-activated cell sorting, TBARS, thiobarbituric acid reactive substances, Empa, empagliflozin, RER, respiratory exchange ratio, Adiposity, lcsh:R5-920, Glucose tolerance test, medicine.diagnostic_test, NEFA, non-esterified fatty acid, Fatty Acids, CT, computed tomographic, WAT, white adipose tissue, DIO, high-fat-diet-induced obese, General Medicine, TG, triglycerides, Adipose Tissue, H&E, haematoxylin and eosin, GTT, glucose tolerance test, lcsh:Medicine (General), Oxidation-Reduction, Research Paper, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, NASH, non-alcoholic steatohepatitis, Adipose tissue macrophages, Biology, Diet, High-Fat, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Insulin resistance, VCO2, carbon dioxide production, FGF21, fibroblast growth factor, Internal medicine, UCP1, uncoupling protein 1, medicine, Empagliflozin, Animals, Hypoglycemic Agents, Obesity, Benzhydryl Compounds, Muscle, Skeletal, Sodium-Glucose Transporter 2 Inhibitors, ITT, insulin tolerance test, VO2, oxygen consumption, Inflammation, Macrophages, lcsh:R, SGLT, sodium/glucose cotransporter, Sodium glucose cotransporter-2 inhibitor, Body Weight, Insulin tolerance test, ALT, Alanine aminotransferase, Energy metabolism, UGE, urinary glucose excretion, Macrophage Activation, medicine.disease, BAT, brown adipose tissue, TC, total cholesterol, Fatty Liver, AMPK, AMP-activated protein kinase, Glucose, 030104 developmental biology, Endocrinology, Insulin Resistance, LMs, liver macrophages, Diet-induced obese, Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c85fd9e3671e9effaeef0acf4b89dd1Test
https://doi.org/10.1016/j.ebiom.2017.05.028Test

المؤلفون: Shin Yamamoto, Takeshi Imamura, Teruki Miyake, Takao Watanabe, Osamu Yoshida, Masanori Abe, Yoichi Hiasa, Yoshio Tokumoto, Yusuke Oshima, Bunzo Matsuura, Takashi Saitou

المصدر: Biochemistry and Biophysics Reports

مصطلحات موضوعية: TPEM, two-photon excitation microscopy, 0301 basic medicine, Pathology, medicine.medical_specialty, NASH, non-alcoholic steatohepatitis, SHG, second harmonic generation, Biophysics, AF, auto-fluorescence, SHG, Biochemistry, Fluorescence imaging, Liver disorder, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Two-photon excitation microscopy, Microscopy, medicine, Chemistry, Fatty liver, NASH, Second-harmonic generation, medicine.disease, Fibrosis, 030104 developmental biology, 030220 oncology & carcinogenesis, Collagen, Steatohepatitis, Ex vivo, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13a99c0a8bc4a20238ced87de10cb42Test

المؤلفون: Patrick Ingiliz, Wolf Peter Hofmann, Anna Schmidt, Kerstin Stein, Peter Buggisch, Lisa Schubert, Marion Muche, Frank Lammert, Stefan Zeuzem, G Felten, Renate Heyne, Jeannette Schwenzer, Johannes Wiegand, Nektarios Dikopoulos, Jörn M. Schattenberg, Thomas Berg, Heiner Wedemeyer

المصدر: JHEP Reports
JHEP Reports, Vol 2, Iss 6, Pp 100168-(2020)

مصطلحات موضوعية: NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, BMI, body mass index, NASH, non-alcoholic steatohepatitis, Liver fibrosis, LSM, liver stiffness measurement, AST, aspartate aminotransferase, Liver disease, FLAG, Fatty Liver Assessment in Germany, NAFLD, ALT, alanine aminotransferase, Internal medicine, APRI, aspartate-aminotransferase-to-platelet ratio index, Internal Medicine, NAFL, non-alcoholic fatty liver, Immunology and Allergy, Medicine, ddc:610, Co-morbidities, lcsh:RC799-869, FIB-4, fibrosis-4, Disease burden, Hepatology, FAST, FibroScan-AST, GGT, gamma-glutamyltransferase, business.industry, Fatty liver, NASH, Gastroenterology, Real world, GLP-1, glucagon-like peptide-1, T2DM, type 2 diabetes mellitus, CVE, cardiovascular event, medicine.disease, Metabolic syndrome, Cohort, lcsh:Diseases of the digestive system. Gastroenterology, CAP, controlled attenuation parameter, Steatohepatitis, business, Body mass index, Research Article, Cohort study

وصف الملف: application/octet-stream

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0cf2c2668ef3cb25aeddbf47a72b83Test
https://doi.org/10.1016/j.jhepr.2020.100168Test