Independent Origin ofPlasmodium falciparumAntifolate Super-Resistance, Uganda, Tanzania, and Ethiopia
| العنوان: | Independent Origin ofPlasmodium falciparumAntifolate Super-Resistance, Uganda, Tanzania, and Ethiopia |
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| المؤلفون: | Richard Pearce, Rosalynn Ord, Mette L Schousboe, Michael Alifrangis, John B. Rwakimari, Caroline A. Lynch, Daniel T. R. Minja, Cally Roper, Reginald A. Kavishe, Jonathan Cox, Hirva Pota, Sidsel Nag, Martha M. Lemnge, John Lusingu, Seyoum Dejene, Deus S. Ishengoma |
| المصدر: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 20, Iss 8, Pp 1280-1286 (2014) |
| بيانات النشر: | Centers for Disease Control and Prevention (CDC), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Pfdhps, Epidemiology, vector-borne infections, Drug Resistance, Dihydrofolate reductase, lcsh:Medicine, Tanzania, intermittent preventive treatment in pregnant women, Gene Frequency, Uganda, Malaria, Falciparum, Child, reproductive and urinary physiology, eastern Africa, Genetics, biology, single-nucleotide polymorphism, Infectious Diseases, Child, Preschool, Mutation (genetic algorithm), Microsatellite, dihydropteroate synthetase, medicine.drug, Microbiology (medical), microsatellite, Lineage (genetic), Adolescent, Plasmodium falciparum, malaria, Pfdhfr, parasites, lcsh:Infectious and parasitic diseases, resistance, Young Adult, parasitic diseases, medicine, Humans, lcsh:RC109-216, Allele, Alleles, Dihydropteroate Synthase, Research, lcsh:R, Infant, medicine.disease, biology.organism_classification, Sulfadoxine/pyrimethamine, sulfadoxine-pyrimethamine, Tetrahydrofolate Dehydrogenase, Haplotypes, Mutation, Folic Acid Antagonists, Ethiopia, Malaria, Microsatellite Repeats |
| الوصف: | Comprehensive surveillance is needed to support sulfadoxine–pyrimethamine intermittent preventive treatment in pregnant women. Super-resistant Plasmodium falciparum threatens the effectiveness of sulfadoxine–pyrimethamine in intermittent preventive treatment for malaria during pregnancy. It is characterized by the A581G Pfdhps mutation on a background of the double-mutant Pfdhps and the triple-mutant Pfdhfr. Using samples collected during 2004–2008, we investigated the evolutionary origin of the A581G mutation by characterizing microsatellite diversity flanking Pfdhps triple-mutant (437G+540E+581G) alleles from 3 locations in eastern Africa and comparing it with double-mutant (437G+540E) alleles from the same area. In Ethiopia, both alleles derived from 1 lineage that was distinct from those in Uganda and Tanzania. Uganda and Tanzania triple mutants derived from the previously characterized southeastern Africa double-mutant lineage. The A581G mutation has occurred multiple times on local Pfdhps double-mutant backgrounds; however, a novel microsatellite allele incorporated into the Tanzania lineage since 2004 illustrates the local expansion of emergent triple-mutant lineages. |
| وصف الملف: | application/pdf |
| تدمد: | 1080-6059 1080-6040 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4c3383c16ec827c6de8cf9596282b5Test https://doi.org/10.3201/eid2008.131897Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7e4c3383c16ec827c6de8cf9596282b5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10806059 10806040 |
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