نتائج البحث

1

Targeting aberrant DNA hypermethylation as a driver of ATL leukemogenesis by using the new oral demethylating agent OR-2100

المؤلفون: Satoshi Yamashita, Naoko Hattori, Yuki Kurahashi, Toshikazu Ushijima, Naoko Sueoka-Aragane, Tatsuro Watanabe, Akemi Sato, Kensuke Kojima, Hideaki Nakamura, Atsushi Kawaguchi, Shinya Kimura, Eisaburo Sueoka, Nao Yoshida, Kazuharu Kamachi, Seiji Okada, Hiroshi Ureshino, Yuki Fukuda-Kurahashi

المصدر: Blood. 136:871-884

مصطلحات موضوعية: Adult, 0301 basic medicine, Pyridines, viruses, Immunology, Administration, Oral, Decitabine, Antineoplastic Agents, Biology, Biochemistry, Mice, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, medicine, Animals, Humans, Leukemia-Lymphoma, Adult T-Cell, Molecular Targeted Therapy, Cells, Cultured, Aged, Mice, Knockout, Regulation of gene expression, Human T-lymphotropic virus 1, Mice, Inbred BALB C, Gene Expression Regulation, Leukemic, Cell growth, T-cell receptor, Drugs, Investigational, Cell Biology, Hematology, DNA Methylation, Cell Transformation, Viral, HTLV-I Infections, Xenograft Model Antitumor Assays, Demethylation, Demethylating agent, 030104 developmental biology, chemistry, Cell culture, 030220 oncology & carcinogenesis, DNA methylation, Cancer research, Female, medicine.drug, DNA hypomethylation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f0e7224c117c25f69a987a740a43e5Test
https://doi.org/10.1182/blood.2019003084Test

2

A randomized double-blind trial of 3 aspirin regimens to optimize antiplatelet therapy in essential thrombocythemia

المصدر: Blood. 136:171-182

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2745a074f0e9fb3a40b7e799bc767c0Test
https://doi.org/10.1182/blood.2019004596Test

3

The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase

المؤلفون: Sebastian Vogel, Swee Lay Thein, Zenaide M.N. Quezado, James S. Nichols, Taruna Arora, Laurel Mendelsohn, Xunde Wang, Arun S. Shet, Darlene Allen, Christian A. Combs

المصدر: Blood Advances. 2:2672-2680

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Inflammasomes, Caspase 1, Context (language use), Anemia, Sickle Cell, Mice, 03 medical and health sciences, chemistry.chemical_compound, hemic and lymphatic diseases, Internal medicine, NLR Family, Pyrin Domain-Containing 3 Protein, Agammaglobulinaemia Tyrosine Kinase, Animals, Humans, Medicine, Bruton's tyrosine kinase, Platelet, HMGB1 Protein, Receptor, integumentary system, biology, business.industry, Inflammasome, Hematology, Middle Aged, Platelets and Thrombopoiesis, Up-Regulation, Toll-Like Receptor 4, 030104 developmental biology, Endocrinology, chemistry, Ibrutinib, biology.protein, TLR4, Female, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26406e723e23bfe96d742ca16d17b5e5Test
https://doi.org/10.1182/bloodadvances.2018021709Test

4

Serum hepcidin: reference ranges and biochemical correlates in the general population

المؤلفون: Tessel E. Galesloot, Lambertus A. Kiemeney, Joyce J.C. Kroot, Dorlene van Tienoven, Jack F.M. Wetzels, Martin den Heijer, Dorine W. Swinkels, Sita H. Vermeulen, Fred C. G. J. Sweep, Siem M. Klaver, Anneke Geurts-Moespot

المصدر: Blood, 117, e218-25
Blood, 117, 25, pp. e218-25

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Immunology, Population, Iron metabolism Pathogenesis and modulation of inflammation [IGMD 7], Renal function, Enzyme-Linked Immunosorbent Assay, Molecular epidemiology Iron metabolism [NCEBP 1], Biochemistry, Molecular epidemiology [NCEBP 1], chemistry.chemical_compound, Sex Factors, Hepcidins, Reference Values, Total iron-binding capacity, Hepcidin, Internal medicine, Iron metabolism [IGMD 7], Humans, Medicine, education, Molecular epidemiology Aetiology, screening and detection [NCEBP 1], Renal disorder [IGMD 9], Aged, Aged, 80 and over, Creatinine, education.field_of_study, biology, medicine.diagnostic_test, business.industry, Hormonal regulation [IGMD 6], C-reactive protein, Age Factors, Cell Biology, Hematology, Middle Aged, Confidence interval, Ferritin, Endocrinology, chemistry, Multivariate Analysis, Linear Models, biology.protein, Hormonal regulation Aetiology, screening and detection [IGMD 6], Female, business, Antimicrobial Cationic Peptides

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d5795079b07f6976b8942f008cade8Test
https://doi.org/10.1182/blood-2011-02-337907Test

5

Human circadian system causes a morning peak in prothrombotic plasminogen activator inhibitor-1 (PAI-1) independent of the sleep/wake cycle

المؤلفون: Frank A.J.L. Scheer, Steven Shea

المصدر: Blood. 123:590-593

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48a5e7c7bf79f76d59589a69a8d3b64Test
https://doi.org/10.1182/blood-2013-07-517060Test

6

Mammalian target of rapamycin regulates neutrophil extracellular trap formation via induction of hypoxia-inducible factor 1 α

المؤلفون: Mark J. Cody, Elizabeth A. Elliott, Matthew T. Rondina, Jesse W. Rowley, Christian C. Yost, Jared W. Glenn, Alison M. McInturff

المصدر: Blood. 120:3118-3125

مصطلحات موضوعية: Adult, Lipopolysaccharides, Lipopolysaccharide, Neutrophils, Molecular Sequence Data, Immunology, Biology, Biochemistry, Phagocytes, Granulocytes, and Myelopoiesis, chemistry.chemical_compound, Extracellular, Humans, RNA, Small Interfering, Base Pairing, Cells, Cultured, PI3K/AKT/mTOR pathway, Sirolimus, Gene knockdown, Innate immune system, Bacteria, Base Sequence, Effector, TOR Serine-Threonine Kinases, Bacterial Infections, Cell Biology, Hematology, Neutrophil extracellular traps, Hypoxia-Inducible Factor 1, alpha Subunit, Molecular biology, Cell biology, chemistry, Nucleic Acid Conformation, Signal transduction, Extracellular Space, Immunosuppressive Agents, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6288e638b6e26eae0c966a91b3af792fTest
https://doi.org/10.1182/blood-2012-01-405993Test

7

Sorafenib treatment of FLT3-ITD+ acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation

المؤلفون: Christa Ho, Alice M.S. Cheung, Howard C.H. Chow, Heron H C Han, Connie J. Eaves, William W.L. Choi, Tsz Kan Fung, Si Lok, Alvin C.H. Ma, Anskar Y.H. Leung, Yok-Lam Kwong, Cheuk Him Man

المصدر: Blood. 119:5133-5143

مصطلحات موضوعية: Male, Time Factors, Myeloid, Pyridines, Mice, SCID, Biochemistry, Mice, chemistry.chemical_compound, Bone Marrow, Mice, Inbred NOD, hemic and lymphatic diseases, Gene Expression Regulation, Leukemic, Benzenesulfonates, Myeloid leukemia, Hematology, Middle Aged, Sorafenib, Leukemia, Myeloid, Acute, Leukemia, medicine.anatomical_structure, Female, medicine.drug, Crenolanib, Adult, Niacinamide, Transplantation, Heterologous, Immunology, Antineoplastic Agents, Aldehyde Dehydrogenase 1 Family, medicine, Animals, Humans, neoplasms, Quizartinib, Severe combined immunodeficiency, business.industry, Gene Expression Profiling, Phenylurea Compounds, Janus Kinase 3, Matrix Metalloproteinase 15, Retinal Dehydrogenase, Cell Biology, Aldehyde Dehydrogenase, medicine.disease, Protein Structure, Tertiary, fms-Like Tyrosine Kinase 3, chemistry, Drug Resistance, Neoplasm, Mutation, Fms-Like Tyrosine Kinase 3, Cancer research, business, Neoplasm Transplantation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28d5ab680cdd18395850b26dd1c83faTest
https://doi.org/10.1182/blood-2011-06-363960Test

8

The tumor marker Fascin is strongly induced by the Tax oncoprotein of HTLV-1 through NF-κB signals

المؤلفون: Andrea K. Kress, Aileen G. Rowan, Ralph Grassmann, Martina Kalmer, Bernhard Fleckenstein

المصدر: Blood. 117:3609-3612

مصطلحات موضوعية: Adult, Cell signaling, Immunology, macromolecular substances, medicine.disease_cause, Biochemistry, chemistry.chemical_compound, Biomarkers, Tumor, medicine, Transcriptional regulation, Humans, Leukemia-Lymphoma, Adult T-Cell, RNA, Small Interfering, Cells, Cultured, Fascin, Regulation of gene expression, biology, Gene Expression Regulation, Leukemic, Gene Expression Profiling, Microfilament Proteins, NF-kappa B, NF-κB, Gene Products, tax, Cell Biology, Hematology, Microarray Analysis, medicine.disease, biology.organism_classification, Up-Regulation, Leukemia, chemistry, Gene Knockdown Techniques, Human T-lymphotropic virus 1, biology.protein, Cancer research, Carrier Proteins, Carcinogenesis, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5499929582092814e1ea4e48a97a8dTest
https://doi.org/10.1182/blood-2010-09-305805Test

9

Priming innate immune responses to infection by cyclooxygenase inhibition kills antibiotic-susceptible and -resistant bacteria

المؤلفون: Jeremy S. Brown, Melanie Stables, Justine Newson, Catherine Hyams, Derek W. Gilroy, Samir S. Ayoub

المصدر: Blood. 116:2950-2959

مصطلحات موضوعية: Adult, Male, medicine.drug_class, medicine.medical_treatment, Immunology, Antibiotics, Biology, Biochemistry, Article, Pneumococcal Infections, Microbiology, Mice, Young Adult, chemistry.chemical_compound, Immune system, Antibiotic resistance, Phagocytosis, Drug Resistance, Bacterial, Cyclic AMP, medicine, Animals, Humans, Cyclooxygenase Inhibitors, Cyclic adenosine monophosphate, Innate immune system, Anti-Inflammatory Agents, Non-Steroidal, Cell Biology, Hematology, biology.organism_classification, Immunity, Innate, Mice, Inbred C57BL, Streptococcus pneumoniae, Cytokine, chemistry, Cyclooxygenase 2, Cyclooxygenase 1, Prostaglandins, biology.protein, Cytokines, Cyclooxygenase, Bacteria

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81b51ff639199ec7c1685d3f68f808f7Test
https://doi.org/10.1182/blood-2010-05-284844Test

10

P-glycoprotein inhibition using valspodar (PSC-833) does not improve outcomes for patients younger than age 60 years with newly diagnosed acute myeloid leukemia: Cancer and Leukemia Group B study 19808

المؤلفون: Thomas C. Shea, Maria R. Baer, Bayard L. Powell, Eva Hoke, Kati Maharry, Clara D. Bloomfield, Guido Marcucci, Wendy Stock, Steven L. Allen, Ravi Vij, Vera Hars, James W. Vardiman, Daniel J. DeAngelo, Richard A. Larson, Jonathan E. Kolitz, Stephen L. George

المصدر: Blood. 116:1413-1421

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ea90b4b914459553f2f16c6d8f6ecfTest
https://doi.org/10.1182/blood-2009-07-229492Test

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