التفاصيل البيبلوغرافية
| العنوان: |
[Toxicity of 4-chloro-2-nitroaniline and 2-chloro-4-nitroaniline to isolated rat hepatocytes]. |
| المؤلفون: |
COTTALASSO, DAMIANO, PRONZATO, MARIA ADELAIDE, DOMENICOTTI, CINZIA MARIA, NANNI, GIORGIO, G. Barisione, L. Fontana |
| المساهمون: |
Cottalasso, Damiano, Pronzato, MARIA ADELAIDE, Domenicotti, CINZIA MARIA, G., Barisione, L., Fontana, Nanni, Giorgio |
| بيانات النشر: |
Nattioli 1885 Spa:via Codura 1 / B, 43036 Fidenza PR Italy:011 39 0524 84547, EMAIL: edit@mattioli1885.com, Fax: 011 39 0524 84751. |
| سنة النشر: |
1991 |
| المجموعة: |
Università degli Studi di Genova: CINECA IRIS |
| مصطلحات موضوعية: |
Aniline Compound, toxicity, Animals, Dimethyl Sulfoxide, pharmacology, Glucosephosphate Dehydrogenase, analysis, L-Lactate Dehydrogenase, Liver, cytology/drug effects/enzymology, Male, Rats, Rat, Inbred Strains, Time Factors, Trypan Blue |
| الوصف: |
The toxicity of 4-chloro-2-nitroaniline (4C2NA) and 2-chloro-4-nitroaniline (2C4NA) was investigated on isolated rat hepatocytes following 1-3 hours of exposure to 0.2 and/or 2 mM of these xenobiotics. The higher of the two concentrations appeared to induce a statistically significant loss of cellular viability (p less than 0.01 compared to control), judged by Trypan Blue staining, after 3 hours of incubation with these substances means = 58, SD = 7\%; and means = SD = 7\%; for 4C2NA and 2C4NA, respectively). Furthermore, both chloronitroanilines produced an hepatocellular and microsomal damage demonstrated by conspicuous changes in LDH and G-6-Pase activities (p less than 0.01). The exposure to 2 mM of both 4C2NA and/or 2C4NA produced a marked depletion of the intracellular pool of GSH after 3 hours (13 mM/10(6) and 10 mM/10(6) cells, respectively; p less than 0.01). Thus it seems possible that 2C4NA may induce a more severe cellular damage than that induced by 4C2NA. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
STAMPA |
| اللغة: |
Italian |
| العلاقة: |
volume:82; firstpage:253; lastpage:260; numberofpages:7; journal:LA MEDICINA DEL LAVORO; http://hdl.handle.net/11567/381204Test |
| الإتاحة: |
http://hdl.handle.net/11567/381204Test |
| رقم الانضمام: |
edsbas.724A3DD8 |
| قاعدة البيانات: |
BASE |
