دورية أكاديمية
Risk of Corneal Transplant Rejection Following COVID-19 Vaccination: A Systematic Review and Meta-analysis
| العنوان: | Risk of Corneal Transplant Rejection Following COVID-19 Vaccination: A Systematic Review and Meta-analysis |
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| المؤلفون: | Parul Chawla Gupta, Bijaya K. Padhi, Hashem Abu Serhan, Arkadiusz Dziedzic, Mahalaqua Nazli Khatib, Shilpa Gaidhane, Quazi Syed Zahiruddin, Abhay M. Gaidhane, Neelima Kukreti, Sarvesh Rustagi, Prakasini Satapathy |
| المصدر: | Ophthalmology and Therapy, Vol 13, Iss 6, Pp 1635-1645 (2024) |
| بيانات النشر: | Adis, Springer Healthcare, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Ophthalmology |
| مصطلحات موضوعية: | COVID-19 vaccine, Corneal transplantation, Meta-analysis, Systematic review, Ophthalmology, RE1-994 |
| الوصف: | Abstract Introduction The COVID-19 pandemic has initiated an unparalleled global vaccination campaign, raising concerns about the vaccine's effects on various health conditions, including the risk of corneal transplant rejection. This systematic review aimed to identify the relationship between COVID-19 vaccination and rejection of corneal transplant, filling a significant gap in the existing medical literature. Methods A literature search was performed across multiple databases up to February 12, 2024, to identify studies evaluating the risk of corneal transplant rejection post-COVID-19 vaccination. Eligible studies were original research that reported outcomes of corneal graft rejection following vaccination. Nested Knowledge web software facilitated screening and data extraction. The Newcastle–Ottawa Scale was employed for quality assessment. A meta-analysis was conducted to calculate the aggregated relative risk (RR) utilizing R software version 4.3. Results Six studies were included in the qualitative synthesis, with four meeting the criteria for meta-analysis. These studies varied in geographic location, surgical techniques, and types of vaccines used. The pooled RR for corneal transplant rejection following COVID-19 vaccination was 0.816 (95% CI 0.178–1.453), indicating no significant risk of rejection. No statistical heterogeneity was observed among the studies (I 2 = 0%). Conclusions This review and meta-analysis found no significant evidence that COVID-19 vaccination increases the risk of corneal graft rejection. However, the current evidence is insufficient to conclusively determine the vaccine's safety for corneal transplant recipients. These findings underscore the need for additional research to confirm these preliminary results and investigate the long-term effects of COVID-19 vaccination on corneal transplants, aiming to provide evidence-based guidance to healthcare providers and patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2193-8245 2193-6528 |
| العلاقة: | https://doaj.org/toc/2193-8245Test; https://doaj.org/toc/2193-6528Test |
| DOI: | 10.1007/s40123-024-00941-y |
| الوصول الحر: | https://doaj.org/article/b68439f4cd9345ddb265bf9702804726Test |
| رقم الانضمام: | edsdoj.b68439f4cd9345ddb265bf9702804726 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21938245 21936528 |
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| DOI: | 10.1007/s40123-024-00941-y |