Genome-wide association study reveals two new risk loci for bipolar disorder
| العنوان: | Genome-wide association study reveals two new risk loci for bipolar disorder |
|---|---|
| المؤلفون: | Peter R. Schofield, Sandra Meier, Stefan Herms, Paul Brennan, Susanne Moebus, Jana Strohmaier, Paul Grof, Nicholas G. Martin, Grant W. Montgomery, Adam Wright, Susanne Lucae, Maria Grigoroiu-Serbanescu, Alexey Polonikov, Peter Propping, Stephanie H. Witt, Andreas J. Forstner, Joanna Hauser, Fabio Rivas, Markus Leber, René Breuer, Piotr M. Czerski, Johannes Schumacher, Manolis Kogevinas, Neonila Szeszenia-Dabrowska, Scott D. Gordon, Sven Cichon, Jolanta Lissowska, Wolfgang Maier, Tim Becker, Alexander S. Tiganov, Thomas W. Mühleisen, Andreas Reif, Manuel Mattheisen, Michael Bauer, Galina Pantelejeva, Thomas G. Schulze, Philip B. Mitchell, Jens Treutlein, André Lacour, Marcella Rietschel, Lilia I. Abramova, Valery Krasnow, Andrea Pfennig, Martin Alda, Alexander Chuchalin, Lutz Priebe, Per Hoffmann, Janice M. Fullerton, Jutta Kammerer-Ciernioch, Markus M. Nöthen, Fermín Mayoral, Helmut Vedder, M.P. Schwarz, Gulja Babadjanova, Guy A. Rouleau, Franziska Degenhardt, Elza Khusnutdinova, Martin Hautzinger, James McKay, Bertram Müller-Myhsok, Catherine Laprise, Gustavo Turecki, Sarah E. Medland |
| المصدر: | Nature Communications 5(1), 3339 (2014). doi:10.1038/ncomms4339 Mühleisen, T W, Leber, M, Schulze, T G, Strohmaier, J, Degenhardt, F, Treutlein, J, Mattheisen, M, Forstner, A J, Schumacher, J, Breuer, R, Meier, S, Herms, S, Hoffmann, P, Lacour, A, Witt, S H, Reif, A, Müller-Myhsok, B, Lucae, S, Maier, W, Schwarz, M, Vedder, H, Kammerer-Ciernioch, J, Pfennig, A, Bauer, M, Hautzinger, M, Moebus, S, Priebe, L, Czerski, P M, Hauser, J, Lissowska, J, Szeszenia-Dabrowska, N, Brennan, P, McKay, J D, Wright, A, Mitchell, P B, Fullerton, J M, Schofield, P R, Montgomery, G W, Medland, S E, Gordon, S D, Martin, N G, Krasnow, V, Chuchalin, A, Babadjanova, G, Pantelejeva, G, Abramova, L I, Tiganov, A S, Polonikov, A, Khusnutdinova, E, Alda, M, Grof, P, Rouleau, G A, Turecki, G, Laprise, C, Rivas, F, Mayoral, F, Kogevinas, M, Grigoroiu-Serbanescu, M, Propping, P, Becker, T, Rietschel, M, Nöthen, M M & Cichon, S 2014, ' Genome-wide association study reveals two new risk loci for bipolar disorder ', Nature Communications, vol. 5, pp. 3339 . https://doi.org/10.1038/ncomms4339Test Nature Communications 5, 3339 (2014). doi:10.1038/ncomms4339 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Bipolar Disorder, Medizin, General Physics and Astronomy, Locus (genetics), Genome-wide association study, Single-nucleotide polymorphism, Disease, Biology, methods [Genome-Wide Association Study], Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, adenylyl cyclase 2, medicine, Humans, Genetic Predisposition to Disease, Bipolar disorder, ANK3, genetics [Genetic Predisposition to Disease], Genetic association, Genetics, Multidisciplinary, genetics [Adenylyl Cyclases], General Chemistry, medicine.disease, Mental illness, 3. Good health, genetics [Polymorphism, Single Nucleotide], Female, ddc:500, genetics [Bipolar Disorder], Genome-Wide Association Study, Adenylyl Cyclases |
| الوصف: | Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide association studies (GWAS) have robustly identified the first common genetic variants involved in disease aetiology. The data also provide strong evidence for the presence of multiple additional risk loci, each contributing a relatively small effect to BD susceptibility. Large samples are necessary to detect these risk loci. Here we present results from the largest BD GWAS to date by investigating 2.3 million single-nucleotide polymorphisms (SNPs) in a sample of 24,025 patients and controls. We detect 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk loci ANK3, ODZ4 and TRANK1, as well as the risk locus ADCY2 (5p15.31) and a region between MIR2113 and POU3F2 (6q16.1). ADCY2 is a key enzyme in cAMP signalling and our finding provides new insights into the biological mechanisms involved in the development of BD. |
| تدمد: | 2041-1723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4299677c5f4a942ff0d5e886163ed29aTest https://doi.org/10.1038/ncomms4339Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4299677c5f4a942ff0d5e886163ed29a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
|---|