دورية أكاديمية
Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
| العنوان: | Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors |
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| المؤلفون: | Jay H. Kalin, Muzhou Wu, Andrea V. Gomez, Yun Song, Jayanta Das, Dawn Hayward, Nkosi Adejola, Mingxuan Wu, Izabela Panova, Hye Jin Chung, Edward Kim, Holly J. Roberts, Justin M. Roberts, Polina Prusevich, Jeliazko R. Jeliazkov, Shourya S. Roy Burman, Louise Fairall, Charles Milano, Abdulkerim Eroglu, Charlotte M. Proby, Albena T. Dinkova-Kostova, Wayne W. Hancock, Jeffrey J. Gray, James E. Bradner, Sergio Valente, Antonello Mai, Nicole M. Anders, Michelle A. Rudek, Yong Hu, Byungwoo Ryu, John W. R. Schwabe, Andrea Mattevi, Rhoda M. Alani, Philip A. Cole |
| المصدر: | Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
| بيانات النشر: | Nature Portfolio |
| سنة النشر: | 2018 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Science |
| الوصف: | Alteration of the epigenetic landscape has been implicated in several disease processes, where targeting histone modifiers may have therapeutic applications. Here the authors report a bifunctional small molecule inhibitor that simultaneously targets the deacetylase (HDAC1) and demethylase (LSD1) activities of the CoREST complex. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | https://doi.org/10.1038/s41467-017-02242-4Test; https://doaj.org/toc/2041-1723Test; https://doaj.org/article/879832a39de54eeeb00cc6a12113408eTest |
| DOI: | 10.1038/s41467-017-02242-4 |
| الإتاحة: | https://doi.org/10.1038/s41467-017-02242-4Test https://doaj.org/article/879832a39de54eeeb00cc6a12113408eTest |
| رقم الانضمام: | edsbas.1B29BB68 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-017-02242-4 |