In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules
| العنوان: | In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules |
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| المؤلفون: | Derry C. Roopenian, Vrajesh V. Parekh, Jingbo Yan, Danyvid Olivares-Villagómez, Luc Van Kaer, Srdjan Dragovic, Timothy M. Hill, Yanice V. Mendez-Fernandez, Sebastian Joyce |
| المصدر: | The Journal of Experimental Medicine |
| بيانات النشر: | Rockefeller University Press, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | T cell, Immunology, Antigen presentation, CD8-Positive T-Lymphocytes, Major histocompatibility complex, Aminopeptidases, Article, Minor Histocompatibility Antigens, Mice, 03 medical and health sciences, 0302 clinical medicine, Antigen, MHC class I, medicine, Animals, Immunology and Allergy, Cytotoxic T cell, 030304 developmental biology, Mice, Knockout, Antigen Presentation, 0303 health sciences, biology, Antigen processing, Histocompatibility Antigens Class I, H-2 Antigens, Articles, Cell Biology, Molecular biology, 3. Good health, medicine.anatomical_structure, Gene Expression Regulation, biology.protein, Peptides, CD8, 030215 immunology |
| الوصف: | Endoplasmic reticulum (ER)-associated aminopeptidase (ERAP)1 has been implicated in the final proteolytic processing of peptides presented by major histocompatibility complex (MHC) class I molecules. To evaluate the in vivo role of ERAP1, we have generated ERAP1-deficient mice. Cell surface expression of the class Ia molecules H-2Kb and H-2Db and of the class Ib molecule Qa-2 was significantly reduced in these animals. Although cells from mutant animals exhibited reduced capacity to present several self- and foreign antigens to Kb-, Db-, or Qa-1b–restricted CD8+ cytotoxic T cells, presentation of some antigens was unaffected or significantly enhanced. Consistent with these findings, mice generated defective CD8+ T cell responses against class I–presented antigens. These findings reveal an important in vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. |
| تدمد: | 1540-8140 0021-9525 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09a8b6b98d09de90406dd1802af44caTest https://doi.org/10.1083/jcb1726oia14Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e09a8b6b98d09de90406dd1802af44ca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15408140 00219525 |
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