المؤلفون: Struwe, Michel A.^1,2 mstruwe@strubio.uni-kiel.de, Scheidig, Axel J.¹, Clement, Bernd²

المصدر: Journal of Biological Chemistry. Nov2023, Vol. 299 Issue 11, p1-19. 19p.

مصطلحات موضوعية: *PRODRUGS, *DRUG target, *GENOME-wide association studies, *MITOCHONDRIA, *ENZYME metabolism, *MOLYBDENUM enzymes, *ENZYMES

المؤلفون: Romei, Matthew G.¹ mgromei92@gmail.com, Leonard, Brandon¹, Kim, Ingrid¹, Hok Seon Kim¹, Lazar, Greg A.¹

المصدر: Journal of Biological Chemistry. May2023, Vol. 299 Issue 5, p1-15. 15p.

مصطلحات موضوعية: *DRUG target, *ENZYME specificity, *MONOCLONAL antibodies, *PROTEOLYTIC enzymes, *ENZYMES, *PROOF of concept

المؤلفون: Baskaran, Pranetha, Mihaylov, Simeon R, Vinsland, Elin, Shah, Kriti, Granat, Lucy, Ultanir, Sila K, Tee, Andrew R, Murn, Jernej, Bateman, Joseph M

المصدر: Journal of Biological Chemistry. 299(1)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Brain Disorders, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Animals, Mice, Adaptor Proteins, Signal Transducing, Cell Line, Mechanistic Target of Rapamycin Complex 1, Morphogenesis, Phosphorylation, Regulatory-Associated Protein of mTOR, Serine, Sirolimus, TOR Serine-Threonine Kinases, Transcription Factors, Cell Growth Processes, Carrier Proteins, Raptor, Unkempt, cellular morphogenesis, intrinsically disordered region, mTOR, phosphorylation, Chemical Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3ct8t10zTest

المؤلفون: Nangia-Makker, Pratima¹ ab4566@wayne.edu, Hogan, Victor¹, Balan, Vitaly², Raz, Avraham^1,3 araz@med.wayne.edu

المصدر: Journal of Biological Chemistry. Dec2022, Vol. 298 Issue 12, p1-13. 13p.

مصطلحات موضوعية: *GALECTINS, *DRUG target, *COLLAGEN, *BIOMARKERS, *PEPTIDES, *CHIMERIC proteins, *CLINICAL trials

المؤلفون: Weinhäupl, Katharina¹, Gragera, Marcos², Bueno-Carrasco, M. Teresa², Arranz, Rocío², Krandor, Olga³, Akopian, Tatos³, Soares, Raquel^1,4, Rubin, Eric³, Felix, Jan^5,6 Jan.Felix@UGent.be, Fraga, Hugo^1,4 hfraga@med.up.pt

المصدر: Journal of Biological Chemistry. Nov2022, Vol. 298 Issue 11, p1-11. 11p.

مصطلحات موضوعية: *DRUG target, *DRUG development, *MYCOBACTERIUM tuberculosis, *ANTIBIOTICS, *PROTEOLYSIS, *PROTEOLYTIC enzymes, *ADENOSINE triphosphatase

المؤلفون: Yu, Zanlin, Chen, Junliang, Takagi, Enzo, Wang, Feng, Saha, Bidisha, Liu, Xi, Joubert, Lydia-Marie, Gleason, Catherine E, Jin, Mingliang, Li, Chengmin, Nowotny, Carlos, Agard, David, Cheng, Yifan, Pearce, David

المصدر: Journal of Biological Chemistry. 298(9)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Cardiovascular, Emerging Infectious Diseases, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Humans, Immediate-Early Proteins, Mechanistic Target of Rapamycin Complex 1, Monomeric GTP-Binding Proteins, Phosphorylation, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins c-akt, Rapamycin-Insensitive Companion of mTOR Protein, Sirolimus, Transcription Factors, Akt, SGK1, conformation change, cryo-EM, mTORC2, structure, substrate specificity, Chemical Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9589f51qTest

المؤلفون: Masui, Kenta, Harachi, Mio, Ikegami, Shiro, Yang, Huijun, Onizuka, Hiromi, Yong, William H, Cloughesy, Timothy F, Muragaki, Yoshihiro, Kawamata, Takakazu, Arai, Nobutaka, Komori, Takashi, Cavenee, Webster K, Mischel, Paul S, Shibata, Noriyuki

المصدر: Journal of Biological Chemistry. 294(51)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biological Sciences, Brain Cancer, Neurosciences, Cancer, Brain Disorders, Rare Diseases, Genetics, Active Transport, Cell Nucleus, Animals, Brain Neoplasms, Cell Line, Tumor, Cell Survival, Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Glioblastoma, Histones, Humans, Immediate-Early Proteins, Intercellular Signaling Peptides and Proteins, Iron, Mechanistic Target of Rapamycin Complex 2, Metabolome, Mice, Neoplasm Transplantation, Promoter Regions, Genetic, Protein Serine-Threonine Kinases, Proto-Oncogene Proteins c-akt, Pyruvate Dehydrogenase (Lipoamide), Signal Transduction, mammalian target of rapamycin, histone acetylation, glucose metabolism, acetyl coenzyme A, iron metabolism, glioblastoma, Chemical Sciences, Medical and Health Sciences, Biochemistry & Molecular Biology, Biological sciences, Biomedical and clinical sciences, Chemical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6jn1c8jgTest

المؤلفون: Chandler, Peter G.¹, Li Lynn Tan², Porebski, Benjamin T.³, Green, James S.¹, Riley, Blake T.^1,4, Broendum, Sebastian S.¹, Hoke, David E.¹, Falconer, Robert J.⁵, Munro, Trent P.⁶, Buckle, Malcolm⁷, Jackson, Colin J.² colin.jackson@anu.edu.au, Buckle, Ashley M.¹ ashley.buckle@monash.edu

المصدر: Journal of Biological Chemistry. Jan-Jun2021, Vol. 296, p1-10. 10p.

مصطلحات موضوعية: *DRUG target, *PROTEIN domains, *CLINICAL trials, *OLIGOMERIZATION

المؤلفون: Parthasarathy, Anutthaman¹, Borrego, Eli J.¹, Savka, Michael A.¹, Dobson, Renwick C. J.^2,3, Hudson, André O.¹ aohsbi@rit.edu

المصدر: Journal of Biological Chemistry. Jan-Jun2021, Vol. 296, p1-25. 25p.

مصطلحات موضوعية: *DRUG target, *DEFENSINS, *THERAPEUTICS, *PARASITIC diseases, *PLANT metabolites, *PHENYLPROPANOIDS, *DRUG development

المؤلفون: Jie Yang^1,2, Weibin Gong¹, Si Wu^1,2, Hong Zhang^1,2 zhangh@moon.ibp.ac.cn, Perrett, Sarah^1,2 sarah.perrett@cantab.net

المصدر: Journal of Biological Chemistry. Jan-Jun2021, Vol. 296, p1-13. 13p.

مصطلحات موضوعية: *MICHAEL reaction, *DRUG target, *CYSTEINE, *QUALITY control, *POLYETHERSULFONE, *CANCER prognosis