دورية
Efficient priming of antigen-specific cytotoxic T lymphocytes by human cord blood dendritic cells.
| العنوان: | Efficient priming of antigen-specific cytotoxic T lymphocytes by human cord blood dendritic cells. |
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| المؤلفون: | Salio, Mariolina, Dulphy, Nicolas, Renneson, Joelle, Herbert, Mark, McMichael, Andrew, Marchant, Arnaud, Cerundolo, Vincenzo |
| المصدر: | International Immunology; October 2003, Vol. 15 Issue: 10 p1265-1273, 9p |
| مستخلص: | Previous studies have suggested that defective immune responses in early life may be related to the immaturity of neonatal antigen-presenting cells. To test this hypothesis, we assessed the capacity of neonatal dendritic cells (DC) to prime and polarize in vitro human naive antigen-specific T cells. We report that mature cord blood DC efficiently prime an oligoclonal population of antigen-specific CD8 T cells, capable of cytolytic activity and IFN-gamma secretion. In contrast, cells primed by immature cord blood DC do not acquire cytolytic activity and secrete lower amounts of IFN-gamma. Upon priming by either immature or mature DC, neonatal T cells acquire markers of activation and differentiation towards effector-memory cells. Our results demonstrate that, if appropriately activated, neonatal DC can prime efficient cytotoxic T lymphocyte (CTL) responses. Furthermore, these findings have important implications for the development of vaccine strategies in early life and for the reconstitution of a functional CTL repertoire after bone marrow transplantation. |
| قاعدة البيانات: | Supplemental Index |
Full Text Finder | تدمد: | 09538178 14602377 |
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| DOI: | 10.1093/intimm/dxg123 |