Macrophage Subsets in Obesity, Aligning the Liver and Adipose Tissue
| العنوان: | Macrophage Subsets in Obesity, Aligning the Liver and Adipose Tissue |
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| المؤلفون: | Anneleen Remmerie, Liesbet Martens, Charlotte L. Scott |
| المصدر: | Frontiers in Endocrinology FRONTIERS IN ENDOCRINOLOGY Frontiers in Endocrinology, Vol 11 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, POLARIZATION, Endocrinology, Diabetes and Metabolism, ADIPOCYTE DEATH, Adipose tissue, 030209 endocrinology & metabolism, Inflammation, Context (language use), Disease, Review, Biology, liver, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, INFLAMMATION, Non-alcoholic Fatty Liver Disease, LOCAL PROLIFERATION, medicine, Medicine and Health Sciences, Macrophage, Animals, Humans, NASH (non-alcoholic steatohepatitis), Obesity, Metabolic Syndrome, lcsh:RC648-665, NONALCOHOLIC STEATOHEPATITIS, HEPATIC RECRUITMENT, Macrophages, Fatty liver, NICHE, Biology and Life Sciences, single-cell, medicine.disease, macrophages, adipose tissue, 030104 developmental biology, Immunology, CELLS, Metabolic syndrome, medicine.symptom, DEPLETION, Inflammation Mediators, heterogeneity, SPI-C, non-alcoholic fatty liver disease (NAFLD) |
| الوصف: | The increasing prevalence of obesity is accompanied by a rising incidence in metabolic syndrome and related pathologies such as non-alcoholic fatty liver disease. Macrophages are hypothesized to play central roles in these diseases, through their role as inflammatory mediators and as such are thought to be potential targets for future therapies. Recently, single cell technologies have revealed significant heterogeneity within the macrophage pool in both liver and adipose tissue in obesity. Thus current efforts are focused on dissecting this heterogeneity and understanding the distinct functions of the individual subsets. In this review, we discuss the current knowledge regarding macrophage heterogeneity, ontogeny and functions in the context of obese adipose tissue and fatty liver disease and attempt to align the distinct populations described to date. |
| وصف الملف: | text/plain |
| تدمد: | 1664-2392 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d4176e5893622d3bdbf0e1629d38caTest https://pubmed.ncbi.nlm.nih.gov/32411096Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....03d4176e5893622d3bdbf0e1629d38ca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16642392 |
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