Acanthosis nigricans in the knuckles: An early, accessible, straightforward, and sensitive clinical tool to predict insulin resistance
| العنوان: | Acanthosis nigricans in the knuckles: An early, accessible, straightforward, and sensitive clinical tool to predict insulin resistance |
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| المؤلفون: | Minerva Gómez-Flores, Rene Rodriguez-Gutierrez, José Gerardo González-González, Juan Montes-Villarreal, Gloria González-Saldivar, Anasofia Elizondo-Plazas, Andrés Marcelo Treviño-Alvarez, Alejandro Salcido-Montenegro, Jorge Ocampo-Candiani, Neri Alejandro Álvarez-Villalobos |
| المصدر: | Dermato-endocrinology |
| بيانات النشر: | Taylor & Francis, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, obesity, diabetes, business.industry, Endocrinology, Diabetes and Metabolism, Clinical marker, nutritional and metabolic diseases, Acanthosis nigricans, 030209 endocrinology & metabolism, Dermatology, Original Articles, medicine.disease, Obesity, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Insulin resistance, Diabetes mellitus, Internal medicine, insulin resistance, medicine, business, clinical marker |
| الوصف: | Any clinical/biochemical marker revealing obesity or diabetes before their appearance is valuable. Insulin resistance (IR) is present in both disorders many years before occurrence. Accordingly, we determined whether acanthosis nigricans (AN) in the knuckles is associated to higher insulin and homeostasis model assessment for estimated insulin resistance (HOMA-IR) index values, and assessed the influence of body-mass index (BMI) and the diagnostic performance of AN in the knuckles to detect IR. In this cross-sectional controlled study, we included men or women, 18 to 23 years old, with or without AN in the knuckles. In 149 cases with AN in the knuckles and 145 controls, fasting insulin was higher in cases (13.45 µU/mL ± 7.8 vs. 8.59 µU/mL ± 3.63, P < .001, respectively). Mean HOMA-IR index was also higher (2.86 ± 1.68 vs. 1.78 ± 0.77, P < .001). A significant increase in fasting insulin and HOMA-IR values between and within BMI groups from normal through obese category was identified in controls and cases. By multivariate regression analysis, cases with normal BMI were significantly associated to a HOMA-IR ≥2.5 (OR = 3.09, CI95% = 1.75–5.48, P = .001). A model of AN in the knuckles, normal BMI, and increased waist circumference allowed identifying 2 out of 3 cases with HOMA-IR index ≥2.5. AN in the knuckles could be addressed with two aims: as an easy, accessible, and costless diagnostic tool suggesting hyperinsulinemia secondary to IR, and, an early marker of IR even in the absence of overweight or obesity. |
| اللغة: | English |
| تدمد: | 1938-1980 1938-1972 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b8558cd24aec0b4fa0c4ee21f1b843Test http://europepmc.org/articles/PMC6166604Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b0b8558cd24aec0b4fa0c4ee21f1b843 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19381980 19381972 |
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